Predoctoral Training Program in Trans-Disciplinary Pharmacological Sciences

描述（由申请人提供）：这是一个应用程序，以扩大现有的跨学科分子药理学和生理学在布朗大学博士前培训计划。该培训计划旨在培养能够在跨学科领域建立独立研究的毕业生，为现代药理学做出贡献。该培训计划将在研究生院批准的分子药理学和生理学研究生课程内进行，并包括来自布朗大学多个部门的经验丰富的培训教师，包括布朗大学沃伦阿尔珀特医学院。申请的资金为期5年，用于01年的2名博士前学员和02- 05年的4名学员。培训教师的研究生产力很强，其系统和复杂方法的多样性反映了当今多学科环境所需的培训类型，为药理学做出了根本性的重要贡献。该计划内的三个专业化轨道包括分子药理学，结构药理学和转化药理学。培训教师在分子和细胞信号转导，细胞信号传导中重要的蛋白质结构生物学，突触功能和调节，离子通道生物物理学，离子通道和受体在人类疾病和发育（包括心血管疾病）中的功能，以及转基因动物模型等领域具有研究优势。该计划具有很强的身份，并通过跨学科的核心课程，研讨会系列，互动实验室轮换，以及高度个性化的关注演讲和写作技能的发展实现整合和动力。因此，该计划在现代药理科学中发挥重要作用的领域提供广泛而全面的培训。学员是从一个强大的，多样化的人才库中招募的，有几个行之有效的机制来吸引和留住来自代表性不足群体的学生。该培训计划的毕业生将从事尖端的基础药理学研究，他们将开发出一套对新药和治疗策略开发至关重要的技能。

DESCRIPTION (provided by applicant): This is an application to expand an existing predoctoral training program in trans-disciplinary molecular pharmacology and physiology at Brown University. The training program is designed to produce graduates capable of establishing independent research in the interdisciplinary fields contributing to modern pharmacological sciences. The training program will be operated within the Graduate School approved Molecular Pharmacology and Physiology Graduate Program, and includes highly experienced training faculty drawn from several departments at Brown University including the Warren Alpert Medical School of Brown University. Funds are requested for 5 years, for 2 predoctoral trainees in year 01 and 4 trainees in years 02- 05. The research productivity of the training faculty is strong, and in its diversity of systems and sophisticated methodologies reflects the type of training that is needed in today's multidisciplinary environment to make fundamentally important contributions to the pharmacological sciences. The three tracks of specialization within the program include Molecular Pharmacology, Structural Pharmacology, and Translational Pharmacology. The training faculty have research strengths in the areas of molecular and cellular signal transduction, structural biology of proteins important in cell signaling, synaptic function and regulation, ion channel biophysics, ion channel and receptor function in human disease and development including cardiovascular disease, and transgenic animal models. The program has a strong identity, and achieves integration and momentum through trans-disciplinary Core courses, a seminar series, interactive laboratory rotations, and highly individualized attention to the development of presentation and writing skills. The program thus offers broad yet Well-integrated training in areas playing an important role in the modern pharmacological sciences. Trainees are recruited from a strong, diverse pool, and there are several proven mechanisms in place to attract and retain students from under-represented groups. The graduates from this training program will have pursued cutting-edge, fundamental pharmacological research, and they will have developed a skill set important for the development of new drugs and therapeutic strategies.