Predoctoral Training Program in Trans-Disciplinary Pharmacological Sciences

描述(由申请人提供)：这是一份申请，旨在扩大布朗大学现有的跨学科分子药理学和生理学博士前培训计划。该培训计划旨在培养能够在跨学科领域建立独立研究的毕业生，为现代药理学做出贡献。培训计划将在研究生院批准的分子药理学和生理学研究生计划范围内进行，其中包括来自布朗大学几个系的经验丰富的培训教师，其中包括布朗大学沃伦·阿尔伯特医学院。申请为期5年的经费，01年度2名博士前实习生和02-05年度4名实习生。培训教师的研究生产力很强，其系统和复杂方法的多样性反映了在当今多学科环境中需要的培训类型，以对药理学科学做出根本上的重要贡献。该计划中的三个专业轨道包括分子药理学、结构药理学和翻译药理学。培训人员在分子和细胞信号转导、细胞信号转导中重要的蛋白质结构生物学、突触功能和调节、离子通道生物物理学、人类疾病和发育(包括心血管疾病)中的离子通道和受体功能以及转基因动物模型等领域拥有研究实力。该项目具有很强的认同感，通过跨学科的核心课程、研讨会系列、互动实验室轮换以及高度个性化的对演示和写作技能的发展的关注，实现了整合和势头。因此，该计划在现代药理学中发挥重要作用的领域提供广泛而又整合良好的培训。受训者是从一个强大的、多样化的人才库中招募的，而且有几个行之有效的机制来吸引和留住来自代表性不足群体的学生。该培训计划的毕业生将从事尖端的基础药理学研究，他们将发展一套对新药和治疗策略开发至关重要的技能。

DESCRIPTION (provided by applicant): This is an application to expand an existing predoctoral training program in trans-disciplinary molecular pharmacology and physiology at Brown University. The training program is designed to produce graduates capable of establishing independent research in the interdisciplinary fields contributing to modern pharmacological sciences. The training program will be operated within the Graduate School approved Molecular Pharmacology and Physiology Graduate Program, and includes highly experienced training faculty drawn from several departments at Brown University including the Warren Alpert Medical School of Brown University. Funds are requested for 5 years, for 2 predoctoral trainees in year 01 and 4 trainees in years 02- 05. The research productivity of the training faculty is strong, and in its diversity of systems and sophisticated methodologies reflects the type of training that is needed in today's multidisciplinary environment to make fundamentally important contributions to the pharmacological sciences. The three tracks of specialization within the program include Molecular Pharmacology, Structural Pharmacology, and Translational Pharmacology. The training faculty have research strengths in the areas of molecular and cellular signal transduction, structural biology of proteins important in cell signaling, synaptic function and regulation, ion channel biophysics, ion channel and receptor function in human disease and development including cardiovascular disease, and transgenic animal models. The program has a strong identity, and achieves integration and momentum through trans-disciplinary Core courses, a seminar series, interactive laboratory rotations, and highly individualized attention to the development of presentation and writing skills. The program thus offers broad yet Well-integrated training in areas playing an important role in the modern pharmacological sciences. Trainees are recruited from a strong, diverse pool, and there are several proven mechanisms in place to attract and retain students from under-represented groups. The graduates from this training program will have pursued cutting-edge, fundamental pharmacological research, and they will have developed a skill set important for the development of new drugs and therapeutic strategies.