Predoctoral Training Program in Trans-Disciplinary Pharmacological Sciences

描述（由申请人提供）：这是一份申请，旨在扩展布朗大学现有的跨学科分子药理学和生理学博士前培训项目。该培训计划旨在培养能够在跨学科领域建立独立研究的毕业生，为现代药理学做出贡献。培训计划将在研究生院批准的分子药理学和生理学研究生课程中进行，并包括来自布朗大学几个部门的经验丰富的培训教师，包括布朗大学沃伦·阿尔珀特医学院。申请资助期为5年，其中01年度资助2名博士预科生，02- 05年度资助4名博士预科生。培训教员的研究生产力很强，其系统的多样性和复杂的方法反映了当今多学科环境中需要的培训类型，以对药理学做出根本性的重要贡献。该计划的三个专业化轨道包括分子药理学，结构药理学和转化药理学。培训师资队伍在分子和细胞信号转导、细胞信号重要蛋白结构生物学、突触功能和调控、离子通道生物物理学、包括心血管疾病在内的人类疾病和发展中的离子通道和受体功能以及转基因动物模型等领域具有研究优势。该项目具有很强的个性，通过跨学科核心课程、系列研讨会、互动实验室轮转以及高度个性化的演讲和写作技能的发展，实现了整合和动力。因此，该计划提供广泛而全面的培训，在现代药理学领域发挥重要作用。学员是从一个强大的、多样化的群体中招募的，并且有一些行之有效的机制来吸引和留住来自代表性不足群体的学生。该培训项目的毕业生将从事尖端的基础药理学研究，他们将开发出一套对开发新药和治疗策略很重要的技能。

DESCRIPTION (provided by applicant): This is an application to expand an existing predoctoral training program in trans-disciplinary molecular pharmacology and physiology at Brown University. The training program is designed to produce graduates capable of establishing independent research in the interdisciplinary fields contributing to modern pharmacological sciences. The training program will be operated within the Graduate School approved Molecular Pharmacology and Physiology Graduate Program, and includes highly experienced training faculty drawn from several departments at Brown University including the Warren Alpert Medical School of Brown University. Funds are requested for 5 years, for 2 predoctoral trainees in year 01 and 4 trainees in years 02- 05. The research productivity of the training faculty is strong, and in its diversity of systems and sophisticated methodologies reflects the type of training that is needed in today's multidisciplinary environment to make fundamentally important contributions to the pharmacological sciences. The three tracks of specialization within the program include Molecular Pharmacology, Structural Pharmacology, and Translational Pharmacology. The training faculty have research strengths in the areas of molecular and cellular signal transduction, structural biology of proteins important in cell signaling, synaptic function and regulation, ion channel biophysics, ion channel and receptor function in human disease and development including cardiovascular disease, and transgenic animal models. The program has a strong identity, and achieves integration and momentum through trans-disciplinary Core courses, a seminar series, interactive laboratory rotations, and highly individualized attention to the development of presentation and writing skills. The program thus offers broad yet Well-integrated training in areas playing an important role in the modern pharmacological sciences. Trainees are recruited from a strong, diverse pool, and there are several proven mechanisms in place to attract and retain students from under-represented groups. The graduates from this training program will have pursued cutting-edge, fundamental pharmacological research, and they will have developed a skill set important for the development of new drugs and therapeutic strategies.