High Resolution Peripheral Quantitative CT

描述(由申请人提供)：骨强度，或骨的抗折性是骨健康研究中的重要成果。骨小梁微结构、骨小梁和皮质体积骨密度(VBMD)作为骨的机械能力和骨折风险的决定因素的独立作用已被确立。因此，人们对能够在体内测量这些参数的高分辨率成像方法非常感兴趣，以便获得新的定量密度测量、显微结构和力学测量骨折风险的方法。该应用程序申请资金购买高分辨率外围定量计算机断层扫描(HR-pQCT)扫描仪。该仪器将安装在临床和转化研究中心(CTRC)营养评估核心中，由费城儿童医院(CHOP)和宾夕法尼亚大学(Penn)临床和转化科学奖联合支持。Core位于中心位置，目前支持14项由美国国立卫生研究院资助的方案(包括多项临床试验)，其中包括双能X射线骨密度仪(DXA)和传统的pQCT骨扫描。PQCT和HR-pQCT都是外周骨骼的活体成像方式，具有辐射剂量低、扫描时间短的特点。然而，HR-pQCT的图像分辨率明显高于pQCT，并提供了详细的骨小梁微结构和皮质骨孔隙率的3D测量，以及皮质骨和松质骨的几何形状和vBMD。重要的是，HR-pQCT图像可以作为有限元分析(FEA)的输入，用于估计整个骨强度或松质骨的弹性模数。该提案是(1)致力于开发新的图像处理算法和？-FEA模型以定量评估骨骼疾病的结构和机械影响的研究人员和(2)临床研究人员之间独特的多学科合作，他们将使用HR-pQCT和这些先进的成像方法作为当前NIH资助的研究的额外重要和创新成果。这些研究的范围从骨髓间充质干细胞疗法治疗儿童严重成骨不全的临床试验，到在超重和肥胖的乳腺癌幸存者的多种族队列中进行的随机减肥和运动干预试验。这将是大费城地区的第一台HR-pQCT扫描仪。将该仪器添加到营养评估核心将导致这项技术的快速和广泛采用，而研究人员的成本最低。我们有一个详细的、随时可以执行的运营计划，其中包括技术专长和支持，以及全面的机构承诺。

DESCRIPTION (provided by applicant): Bone strength, or bone's resistance to fracture is an important outcome in studies of bone health. The independent roles of trabecular microarchitecture and trabecular and cortical volumetric bone mineral density (vBMD) as determinants of bone's mechanical competence and fracture risk have been established. Thus, there is great interest in high-resolution imaging methods capable of measuring these parameters in vivo in order to derive new quantitative densitometric, microstructural and mechanical measures of fracture risk. This application requests funds to purchase a high resolution peripheral quantitative computed tomography (HR- pQCT) scanner. The instrument will be installed in the Clinical and Translational Research Center (CTRC) Nutrition Assessment Core, supported by the joint Children's Hospital of Philadelphia (CHOP) - University of Pennsylvania (Penn) Clinical and Translational Science Award. The Core is centrally located and currently supports 14 NIH-funded protocols (including multiple clinical trials) that include dual energy x-ray absorptiometry (DXA) and conventional pQCT bone scans. Both pQCT and HR-pQCT are in vivo imaging modalities for the peripheral skeleton with low radiation dose and fast scan time. However, HR-pQCT has markedly higher image resolution compared to pQCT, and provides detailed 3D measures of the microarchitecture of trabecular bone and porosity of cortical bone, as well as geometry and vBMD of cortical and trabecular bone. Importantly, HR-pQCT images can be used as input for ¿-Finite Element Analysis (FEA) for estimation of whole bone strength or elastic moduli of trabecular bone. The proposal is a unique multidisciplinary collaboration among (1) investigators dedicated to the development of new image-processing algorithms and ?-FEA models for the quantitative assessment of the structural and mechanical implications of bone disease, and (2) clinical investigators that will use HR-pQCT and these advanced imaging methods as additional significant and innovative outcomes for current NIH funded studies. These studies span the spectrum from a clinical trial of mesenchymal stem cell therapy to treat severe osteogenesis imperfecta in children, to a randomized weight loss and exercise intervention trial in a multi-ethnic cohort of overweight and obese breast cancer survivors. This will be the first HR-pQCT scanner in the greater Philadelphia area. The addition of this instrument to the Nutrition Assessment Core will result in rapid and wide-spread adoption of this technique at minimal cost to investigators. We have a detailed and ready-to-execute plan for operation that includes technical expertise and support, and full institutional commitment.