Upgrade of 500 MHz NMR Spectrometer

描述（由申请人提供）：加州大学圣巴巴拉分校化学和生物化学系的核磁共振设备有两台过时的核磁共振光谱仪，专门用于有机/无机小分子，肽和聚合物的化学研究。要求拨款用最先进的数字控制台和为1H和x核探测优化的室温通用探针取代已有16年历史的500 MHz光谱仪的控制台。我们目前的老一代Varian unity Inova控制台缺乏常规核磁共振分析中常用的当前一代控制台的基本自动化功能，严重限制了仪器的吞吐量和效率。此外，随着控制台组件稳定性的恶化，供应商的支持和替换部件的可用性正在减少。所要求的最先进的控制台和探头替代品提供了急需的自动调谐和调光能力，完整的数字控制信号和射频脉冲路由，改进的锁定灵敏度和稳定性，降低噪音和伪像，并扩展了实验能力。此外，最新的Bruker SmartProbe提供的1H灵敏度比我们目前在仪器上的灵敏度高出一倍以上，同时实现了所有x核的中等灵敏度增益。升级还提供了一个扩大的可变温度范围，提高温度稳定性和更方便的低温设置。升级后的光谱仪将继续在满足该系各种nih资助项目的研究需求方面发挥重要作用。

DESCRIPTION (provided by applicant): The NMR Facility at the Department of Chemistry and Biochemistry UC Santa Barbara houses two outdated NMR spectrometers dedicated to chemistry research of organic/inorganic small molecules, peptides and polymers. Funding is requested to replace the console for a 16-year old 500 MHz spectrometer with a state-of-the-art digital console and a room-temperature universal probe optimized for both 1H and X-nucleus detection. Our current, older generation Varian Untity Inova console lacks basic automation features that are common in current generation of consoles used in routine NMR analysis, severely restricting instrument throughput and efficiency. Moreover, as the stability of the console components deteriorates, vendor support and availability of replacement parts are diminishing. The requested, state-of-the-art console and probe replacements offer much needed auto- tuning and shimming capabilities, complete digital control of signal and RF pulse routing, improved lock sensitivity and stability, reduced noise and artifacts, and expanded experimental capabilities. Moreover, the latest Bruker SmartProbe offers more than double the 1H sensitivity compared to what we currently have on the instrument while achieving a moderate sensitivity gain for all X-nuclei. The upgrade also delivers an expanded variable temperature range, improved temperature stability and more convenient low-temperature setup. The upgraded spectrometer will continue to play an essential role in meeting the research needs of various NIH-funded projects in the department.