Upgrade of 500 MHz NMR Spectrometer

描述(申请人提供)：加州大学圣巴巴拉分校化学和生物化学系的核磁共振设施拥有两台过时的核磁共振光谱仪，专门用于有机/无机小分子、多肽和聚合物的化学研究。请拨出资金，用最先进的数字控制台和针对1H和X核探测进行了优化的室温通用探头来取代已有16年历史的500兆赫分光计的控制台。我们当前的老一代Varian Untity Inova控制台缺乏在常规核磁共振分析中使用的当代控制台中常见的基本自动化功能，严重限制了仪器的吞吐量和效率。此外，随着控制台组件的稳定性恶化，供应商的支持和替换部件的可用性也在减少。所需的最先进的控制台和探头更换提供了亟需的自动调谐和垫片功能、对信号和RF脉冲路径的完全数字控制、提高了锁定灵敏度和稳定性、减少了噪音和伪影，并扩展了实验能力。此外，最新的Bruker SmartProbe提供了比我们目前仪器上的1H灵敏度高一倍以上的灵敏度，同时实现了对所有X核的中等灵敏度增益。此次升级还提供了更大的可变温度范围、更好的温度稳定性和更方便的低温设置。升级后的光谱仪将继续在满足NIH资助的部门各种项目的研究需求方面发挥重要作用。

DESCRIPTION (provided by applicant): The NMR Facility at the Department of Chemistry and Biochemistry UC Santa Barbara houses two outdated NMR spectrometers dedicated to chemistry research of organic/inorganic small molecules, peptides and polymers. Funding is requested to replace the console for a 16-year old 500 MHz spectrometer with a state-of-the-art digital console and a room-temperature universal probe optimized for both 1H and X-nucleus detection. Our current, older generation Varian Untity Inova console lacks basic automation features that are common in current generation of consoles used in routine NMR analysis, severely restricting instrument throughput and efficiency. Moreover, as the stability of the console components deteriorates, vendor support and availability of replacement parts are diminishing. The requested, state-of-the-art console and probe replacements offer much needed auto- tuning and shimming capabilities, complete digital control of signal and RF pulse routing, improved lock sensitivity and stability, reduced noise and artifacts, and expanded experimental capabilities. Moreover, the latest Bruker SmartProbe offers more than double the 1H sensitivity compared to what we currently have on the instrument while achieving a moderate sensitivity gain for all X-nuclei. The upgrade also delivers an expanded variable temperature range, improved temperature stability and more convenient low-temperature setup. The upgraded spectrometer will continue to play an essential role in meeting the research needs of various NIH-funded projects in the department.