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Upgrade of 500 MHz NMR Spectrometer

500 MHz核磁共振波谱仪升级

基本信息

批准号：
8447923
负责人：
Liming Zhang
金额：
$ 34.75万
依托单位：
UNIVERSITY OF CALIFORNIA SANTA BARBARA
依托单位国家：
美国
项目类别：
财政年份：
2013
资助国家：
美国
起止时间：
2013-06-20 至 2014-05-31
项目状态：
已结题

项目摘要

DESCRIPTION (provided by applicant): The NMR Facility at the Department of Chemistry and Biochemistry UC Santa Barbara houses two outdated NMR spectrometers dedicated to chemistry research of organic/inorganic small molecules, peptides and polymers. Funding is requested to replace the console for a 16-year old 500 MHz spectrometer with a state-of-the-art digital console and a room-temperature universal probe optimized for both 1H and X-nucleus detection. Our current, older generation Varian Untity Inova console lacks basic automation features that are common in current generation of consoles used in routine NMR analysis, severely restricting instrument throughput and efficiency. Moreover, as the stability of the console components deteriorates, vendor support and availability of replacement parts are diminishing. The requested, state-of-the-art console and probe replacements offer much needed auto- tuning and shimming capabilities, complete digital control of signal and RF pulse routing, improved lock sensitivity and stability, reduced noise and artifacts, and expanded experimental capabilities. Moreover, the latest Bruker SmartProbe offers more than double the 1H sensitivity compared to what we currently have on the instrument while achieving a moderate sensitivity gain for all X-nuclei. The upgrade also delivers an expanded variable temperature range, improved temperature stability and more convenient low-temperature setup. The upgraded spectrometer will continue to play an essential role in meeting the research needs of various NIH-funded projects in the department.

描述（由申请人提供）：加州大学圣塔芭芭拉分校化学与生物化学系的 NMR 设施拥有两台过时的 NMR 光谱仪，专门用于有机/无机小分子、肽和聚合物的化学研究。需要资金将已有 16 年历史的 500 MHz 光谱仪的控制台更换为最先进的数字控制台和针对 1H 和 X 核检测进行优化的室温通用探头。我们当前的老一代 Varian Untity Inova 控制台缺乏常规 NMR 分析中使用的当前一代控制台中常见的基本自动化功能，严重限制了仪器的吞吐量和效率。此外，随着控制台组件稳定性的恶化，供应商的支持和替换部件的可用性正在减少。所要求的最先进的控制台和探头替代品提供了急需的自动调谐和匀场功能、信号和射频脉冲路由的完整数字控制、改进的锁定灵敏度和稳定性、减少的噪声和伪影以及扩展的实验能力。此外，最新的布鲁克 SmartProbe 的 1H 灵敏度比我们目前仪器上的灵敏度高出一倍以上，同时对所有 X 核实现适度的灵敏度增益。此次升级还提供了更大的可变温度范围、更高的温度稳定性和更方便的低温设置。升级后的光谱仪将继续在满足该部门各种 NIH 资助项目的研究需求方面发挥重要作用。