Neurocircuitry underlying effectiveness of DBS in OCD

本研究将集中于研究清醒行为中涉及回避和奖励行为的回路 灵长类动物灵长类动物是这个项目的关键环节，因为它们很聪明，可以训练它们去执行任务 在模拟人类行为的复杂任务中，感兴趣的领域之间的同源性非常接近， 灵长类动物和人类，有相当多的解剖信息涉及的领域， 在奖励和回避之间起调节作用，并在强迫症（OCD）中起作用。这些领域 包括腹内侧前额叶皮层（vmPFC）、眶额皮层（OFC）、前背侧皮层（ARF）、 扣带皮质（dACC）和腹侧纹状体（VS）。有相当多的数据关于电路的 害怕啮齿动物灭绝。特别是，边缘下（IL）和边缘前（PL）区域似乎具有 在调解恐惧灭绝（怪癖）的相互作用。虽然确切的同源性尚不清楚， 一个合理的假设是IL对应于vmPFC，PL区域对应于dACC。在 相比之下，在灵长类动物中研究这些区域的工作相对较少。这个项目的首要目标是 该项目旨在弥合啮齿动物和灵长类动物之间的差距，这将提供一个重要的框架 用于合理开发旨在治疗人类疾病的DBS策略。 相关性（参见说明）： 强迫症（OCD）是一种慢性精神疾病，影响2-3%的世界各地 人口这是一种排在前十位的疾病。这项研究将检查神经 与强迫症相关的行为基础的网络和机制。这些行为不仅限于 强迫症，但与一系列的情感和成瘾性疾病。集体建议的研究 将产生新的假设，这些大脑网络中的功能障碍是如何表达的， 疾病，并提供洞察正常行为反应的机制。

This project will focus on studying the circuitry involved in avoidance and reward behavior in awake-behaving primates. Primates are a critical link in this project because they are intelligent and can be trained to perform complex tasks that mimic human behaviors, the homology between areas of interest is fairiy close between primates and humans, and there is a considerable anatomic information regarding areas involved in mediating reward and avoidance, and invoked in obsessive-compulsive disorder (OCD). These areas include the ventro-medial prefrontal cortex (vmPFC), the orbitofrontal cortex (OFC), the anterior dorsal cingulate cortex (dACC) and the ventral striatum (VS). There is considerable data regarding the circuitry of fear extinction in rodents. In particular, the infralimic (IL) and pre-limbic (PL) areas appear to have a reciprocal role in the mediating fear extinction (Quirk). Although the exact homology is not clear, a reasonable hypothesis is that IL corresponds to the vmPFC and that area PL corresponds to the dACC. In contrast, there has been relatively little work studying these areas in primates. The overarching goal of this project is to bridge the gap between rodents and primates, which will then provide an important framework for the rational development of DBS strategies aimed at treating human disorders. RELEVANCE (See instructions): Obsessive Compulsive Disorder (OCD) is a chronic psychiatric illness that affects 2-3% of the woridwide population. This is disease is in the top ten dehabilitating diseases. This study will examine the neural network and mechanisms that underiie behaviors associated with OCD. These behaviors not limited to OCD, but are associated with a range of affective and addictive disorders. The collective proposed studies will generate new hypotheses of how dysfunctions within these brain networks are expressed across diseases and provide insight into the mechanisms underiying normal behavioral responses.