High Performance Multi-Modality Small Animal Imaging System

描述（由申请人提供）：美国国立卫生研究院高端仪器奖申请的广泛，长期目标是获得一种新的最先进的高性能小动物（SA） PET/SPECT/CT成像系统，用于小动物的多模态成像，使约翰霍普金斯医学研究所（JHMI）的生物医学研究人员能够获得前所未有的清晰和新的信息，涉及正常和患病动物的解剖，生理和生化过程的不同方面。拟议收购的具体目的是：(1)取代目前服务于JHMI研究界的现有超过7年历史且过时的独立小动物（SA） PET和SPECT/CT系统，以及(2)为用户提供集成的PET/SPECT/CT系统，该系统允许精确地注册多模态图像。为了实现这一目标，我们建议收购一套基于单个TriumphTM龙门的商用Gamma Medica （GM）最先进的高性能集成多模态SA PET/SPECT/CT成像系统。GM多模态SA成像系统由四个部分组成：(1) LabPET 12固定环PET子系统，其双层LYSO/LGSO闪烁体集成了雪崩光电二极管（APD）探测器，并具有12厘米轴向视场；(2)SPECT子系统，其具有2头最先进的固体碲化镉锌（CZT）探测器，具有高能量分辨率，对多同位素成像特别重要；(3)高分辨率微CT子系统，带有可调x射线发生器和可变微焦点x射线管，最高可达到的分辨率小于35微米，特殊脉冲x射线管也允许呼吸门控CT研究；(4)最先进的SA成像配件，包括同时监测温度、心电图和呼吸的生理监测系统，麻醉系统，注射泵，一种用于小动物输入功能测量的血液计数器和灌注泵。拟议的多模态SA PET/SPECT/CT系统将与9.4T小口径MRI系统、Xenogen IVIS 200光学成像系统和Visual Sonics SA超声成像系统一起安置在现有的小动物成像中心（SAIC）。这种组合代表了最完整和最先进的多模态SA成像设备。拟议设备的操作将由一个咨询委员会监督，该委员会由PI、Co-PI和JHMI的主要用户组成。咨询委员会将每年举行两次会议，审查SA成像套件的操作情况，并制定政策和程序，以确保公平使用拟议的设备。

DESCRIPTION (provided by applicant): The broad, long-term objective of the NIH High-End Instrumentation Award application is to acquire a new state-of-the-art high-performance small animal (SA) PET/SPECT/CT imaging system for multi-modality imaging of small animals to allow biomedical researcher at Johns Hopkins Medical Institutes (JHMI) to gain unprecedentedly clear and new information on different aspects of the anatomy, physiology, and biochemical processes involved in normal and diseased animals. The specific aims of the proposed acquisition are: (1) to replace the existing over 7-year old and outdated stand-alone small animal (SA) PET and SPECT/CT systems that are currently serving the JHMI research community, and (2) to provide users with an integrated PET/SPECT/CT system that allows accurate registration of the multimodality images. To achieve the aims, we propose to acquire a commercial Gamma Medica (GM) state-of-the-art high-performance integrated multi- modality SA PET/SPECT/CT imaging system based on a single TriumphTM gantry. The GM multimodality SA imaging system consists of four components: (1) a LabPET 12 stationary ring PET subsystem with dual-layer LYSO/LGSO scintilliators integrated with avalanche photodiode (APD) detectors and with 12 cm axial field-of- view, (2) a SPECT subsystem with 2 -head state-of-the-art solid-state cadmium zinc telluride (CZT) detector based camera modules with high-energy resolution that is especially important for multi-isotope imaging, (3) a high-resolution microCT subsystem with tunable x-ray generator and variable micro focal-spot x-ray tube with highest achievable resolution of less than 35 micron and the special pulsed x-ray tube also allow respiratory gated CT studies, and (4) state-of-the-art SA imaging accessories including a physiological monitoring system that simultaneously monitors temperature, ECG and respiration, a anesthesia system, an injection pump, a blood counter and exfusion pump for input function measurements for small animals. The proposed multi- modality SA PET/SPECT/CT system will be housed in the existing Small Animal Imaging Center (SAIC), together with a 9.4T small bore MRI system, a Xenogen IVIS 200 optical imaging system, and a Visual Sonics SA ultrasound imaging system. This combination represents the most complete and state-of-the-art multimodality SA imaging facility. The operation of the proposed equipment will be overseen by an Advisory Committee formed by the PI, the Co-PI and the major users across JHMI. The Advisory Committee will meet twice a year to review the operation of the SA imaging suite and to set policies and procedures to assure equitable use of the proposed equipment.