Hand-Held Infrared Scanner for Early Detection of Melanoma

用于早期检测黑色素瘤的手持式红外扫描仪

• 批准号: 8522169
• 负责人: Cila Herman
• 金额: $ 12.13万
• 依托单位: JOHNS HOPKINS UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2011
• 资助国家: 美国
• 起止时间: 2011-09-02 至 2015-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8522169
• 关键词: Accounting; Affect; Applications Grants; Area; Benign; Biopsy; Biotechnology; Calibration; Cessation of life; Clinic; Clinical; Clinical Research; Clinical Trials; Clinical Trials Design; Computer Simulation; Computer software; Cutaneous; Cutaneous Melanoma; Data; Data Analyses; Dermatology; Dermoscopy; Detection; Development; Devices; Diagnosis; Diagnostic; Diagnostic Procedure; Disease; Early Diagnosis; Early treatment; Engineering; Enhancing Lesion; Evaluation; Goals; Hand; Heating; Image; Image Analysis; Imagery; Imaging Device; Imaging Techniques; Imaging technology; Incidence; Individual; Intellectual Property; Lead; Lesion; Life Expectancy; Light; Longevity; Malignant - descriptor; Malignant Neoplasms; Masks; Measurement; Methods; Modeling; Mohs Surgery; Morbidity - disease rate; Neoplasm Metastasis; Numeric Rating Scale; Numerical value; Pathologist; Pathology; Patient Recruitments; Patients; Pigments; Probability; Public Health; Radiation therapy; Reading; Research; Resistance; Resolution; Scanning; Sensitivity and Specificity; Simulate; Skin; Staging; System; Technology; Temperature; Testing; Three-Dimensional Image; United States; abstracting; advanced disease; base; chemotherapy; data modeling; design; high risk; improved; in vivo; lifetime risk; melanoma; mortality; novel; outcome forecast; prospective; prototype; research study; response; screening; skin lesion; software development; tool; translational study

DESCRIPTION (provided by applicant): Hand-held infrared scanner for early detection of melanoma Project Summary/Abstract: Melanoma incidence is increasing at one of the fastest rates for all cancers in the United States, with a current lifetime risk of 1 in 58 [1]. Approximately 68,720 melanomas will be diagnosed in 2010, with nearly 8,650 resulting in death [2]. At present, there are no systemic agents available that significantly extend the lifespan of patients with advanced disease and the key to improved survival in all affected individuals remains early diagnosis and treatment. The vast majority of cutaneous melanomas present as pigmented lesions of the skin, and current detection of atypical lesions rely on the subjective ABCDE criteria. The existence of an accurate, simple, objective and quantitative, non-invasive screening and diagnostic tool would therefore be invaluable for the early detection of malignant melanoma in a variety of clinical settings. We hypothesize that malignant pigmented lesions with increased proliferative potential generate quantifiable amounts of heat and possess an ability to reheat more quickly than the surrounding normal skin, thereby creating a marker for melanoma detection. Prior research of the PI, involving a patient study, suggests that the high-accuracy and resolution visualization of the transient thermal response of the skin to a cooling excitation allows for the identification of melanoma lesions in an early stage of the disease and holds the promise of quantifying the malignant potential of skin lesions using a simple numerical scale (from 1 to 10). In the proposed study we plan to: 1. Design, build, calibrate and test in a patient study a prototype hand-held, high-resolution infrared scanner for distinguishing pigmented lesions of varying malignant potential 2. Conduct a patient study to establish quantitative scale describing the malignant potential of a pigmented lesion based on measurement of the transient thermal response 3. Develop and optimize the software and hardware for the imaging and quantitative assessment of pigmented lesions of varying malignant potential The long-term goals of this study are to design, build and optimize a noninvasive, in vivo infrared imaging tool for the quantitative assessment of cutaneous pigmented lesions in order initiate large-scale clinical trials to evaluate and compare the sensitivity and specificity of the proposed tool with other in vivo diagnostic and imaging techniques. Such a tool is expected to decrease unnecessary skin biopsies of benign pigmented lesions and the morbidity and mortality associated with melanoma diagnosis and therapy. An interdisciplinary team will be involved in the research effort: two engineers will be responsible for the development of software and hardware and the modeling effort, three clinicians with expertise in dermatology will be leading the patient recruitment effort for the patient study, and one expert from the public health area will be leading the clinical trial design, conduct, and data analysis efforts. Intellectual property generated through these studies is expected to lead to a biotechnology startup company focused on infrared imaging of cutaneous lesions.

描述（由申请人提供）：用于早期检测黑色素瘤的手持式红外扫描仪项目摘要/摘要：黑色素瘤发病率在美国所有癌症中以最快的速度增长，目前的终生风险为1/58 [1]。2010年将诊断出约68，720例黑色素瘤，其中近8，650例导致死亡[2]。目前，没有全身性药物可显著延长晚期疾病患者的寿命，提高所有受影响个体生存率的关键仍然是早期诊断和治疗。绝大多数皮肤黑色素瘤表现为皮肤色素性病变，目前对非典型病变的检测依赖于主观ABCDE标准。因此，准确、简单、客观和定量的非侵入性筛查和诊断工具的存在对于在各种临床环境中早期检测恶性黑色素瘤是非常宝贵的。我们假设恶性色素性病变的增殖潜力增加，产生可量化的热量，并拥有比周围正常皮肤更快地再热的能力，从而创建一个标记黑色素瘤检测。PI的先前研究（涉及患者研究）表明，皮肤对冷却激励的瞬态热响应的高准确度和分辨率可视化允许在疾病的早期阶段识别黑色素瘤病变，并有望使用简单的数值量表（从1到10）量化皮肤病变的恶性潜力。在这项研究中，我们计划：1。设计，建立，校准和测试在一个病人研究的原型手持，高分辨率红外线扫描仪区分不同的恶性潜力色素病变2。进行一项患者研究，根据瞬态热反应3的测量结果，建立描述色素性病变恶性潜能的定量量表。开发和优化用于不同恶性潜能的色素性病变的成像和定量评估的软件和硬件本研究的长期目标是设计、构建和优化一种非侵入性，用于定量评估皮肤色素性病变的体内红外成像工具，大规模临床试验，以评估和比较所提出的工具与其他体内诊断和成像技术的灵敏度和特异性。这种工具预计将减少不必要的皮肤活检的良性色素性病变和发病率和死亡率与黑色素瘤的诊断和治疗。一个跨学科团队将参与研究工作：两名工程师将负责软件和硬件的开发以及建模工作，三名具有皮肤病学专业知识的临床医生将领导患者研究的患者招募工作，一名来自公共卫生领域的专家将领导临床试验设计，进行和数据分析工作。通过这些研究产生的知识产权预计将导致一个生物技术创业公司专注于皮肤病变的红外成像。

项目成果

Involuntary motion tracking for medical dynamic infrared thermography using a template-based algorithm.

使用基于模板的算法进行医疗动态红外热成像的非自愿运动跟踪。

• DOI: 10.1117/12.2000569
• 发表时间: 2013
• 期刊: Proceedings of SPIE--the International Society for Optical Engineering
• 作者: Cheng,Tze-Yuan;Herman,Cila
• 通讯作者: Herman,Cila

HEAT TRANSFER MODEL AND QUANTITATIVE ANALYSIS OF DEEP TISSUE INJURY.

• DOI: 10.1115/imece2012-88405
• 发表时间: 2012-11
• 期刊: International Mechanical Engineering Congress and Exposition : [proceedings]. International Mechanical Engineering Congress and Exposition
• 作者: Chanmugam A;Bhargava A;Herman C
• 通讯作者: Herman C

Magnetic nanoparticle hyperthermia enhances radiation therapy: A study in mouse models of human prostate cancer.

• DOI: 10.3109/02656736.2015.1005178
• 发表时间: 2015-06
• 期刊: International journal of hyperthermia : the official journal of European Society for Hyperthermic Oncology, North American Hyperthermia Group
• 作者: Attaluri A;Kandala SK;Wabler M;Zhou H;Cornejo C;Armour M;Hedayati M;Zhang Y;DeWeese TL;Herman C;Ivkov R
• 通讯作者: Ivkov R

Motion tracking in infrared imaging for quantitative medical diagnostic applications.

• DOI: 10.1016/j.infrared.2013.10.009
• 发表时间: 2014-01
• 期刊: INFRARED PHYSICS & TECHNOLOGY
• 影响因子: 3.3
• 作者: Cheng, Tze-Yuan;Herman, Cila
• 通讯作者: Herman, Cila

Possibilities and limitations of the ART-Sample algorithm for reconstruction of 3D temperature fields and the influence of opaque obstacles.

• DOI: 10.1016/j.ijheatmasstransfer.2013.03.026
• 发表时间: 2013-07-01
• 期刊: INTERNATIONAL JOURNAL OF HEAT AND MASS TRANSFER
• 影响因子: 5.2
• 作者: Li, Yuanyang;Herman, Cila
• 通讯作者: Herman, Cila