Design and Methodology Core

设计和方法学核心将帮助研究人员设计研究，并使用现有和创新技术的混合物分析数据，以检查与影响乳腺癌女性治疗个体化相关的问题。核心D将通过协商和协作、领导进行中的工作会议以及开发和维护与设计和方法有关的集中资源，为调查人员提供支持。我们的设计和方法学核心的一个重要目标是进行乳腺癌转化生物统计学研究，促进新方法学的发展。 为当前和未来的项目提供实践。该项目有四个具体目标。目标1侧重于指导和监督三个项目所使用的分析和方法的最明显的基本作用。目标2旨在促进和支持初步工作或新的外部研究结果或政策发展中可能建议的辅助和后续研究，目的是从为执行上述三个项目而进行的大量和昂贵的数据收集工作中获得更多好处。在目标3中，研究人员提出要解决两个应用统计问题， 确定统计和生物统计领域的前沿发展，并做必要的工作，以证明这些方法可以可行和实际地回答本计划项目所遇到的方法学问题。目标4，旨在专注于建立集中的资源和协作桥梁，无论是在程序项目和核心，更广泛地在其他群体在UM是专注于转化研究方法，以进一步提高我们的能力，使正确的方法适用于正确的问题。核心D包括具有以下技能的经验丰富的人员：1）高级生物统计分析，包括多水平建模，潜变量，缺失数据和因果推断; 2） 患者和提供者的信念和态度，行为和生活质量的心理测量; 3）调查方法; 4）质量测量和实践概况; 5）实验，准实验和观察设计; 6）管理大型行政和临床数据库的技术方面。

The Design and Methodology Core will assist investigators to design studies and to analyze data using a mixture of established and innovative techniques to examine questions related to influencing individualization of treatment for women with breast cancer. Core D will support investigators through consultation and collaboration, lead work-in-progress sessions, as well as development and maintenance of centralized resources related to design and methodology. An important goal of our Design and Methodology core is to conduct breast cancer translational biostatistical research, facilitating the movement of new methodological approaches into practice for current and future projects. The project has four specific aims. Aim 1 focuses on the most obvious essential role of directing and supervising the analysis and methods used by the three projects. Aim 2 is designed to promote and support ancillary and follow-on studies that might be suggested from the preliminary work, or new external research findings or policy developments, with the goal of providing additional benefits from the large and expensive data collection effort undertaken to carry out the three projects described. In Aim 3, the investigators propose to do work on two applied statistical problems, identifying cutting edge developments in statistical and biostatistical fields and doing the necessary work to demonstrate that these methods can feasibly and practically answer methodological problems encountered by the projects in this program. Aim 4, is designed to focus on building centralized resources and collaborative bridges, both within the Program projects and cores and more broadly to other groups at UM that are focusing on translational research methods to further enhance our ability to bring the right methods to apply to the right problems. Core D includes experienced personnel with skills in: 1) advanced biostatistical analysis including multilevel modeling, latent variables, missing data and causal inference; 2) psychometric measurement of patient and provider beliefs and attitudes, behaviors, and quality of life; 3) survey methodology; 4) quality measurement and practice profiling; 5) experimental, quasi-experimental and observational designs; 6) technical aspects of managing large administrative and clinical databases.