Design and Methodology Core

设计和方法核心将帮助研究人员设计研究并分析数据，使用已有的和创新的技术相结合，检查与影响乳腺癌妇女个体化治疗有关的问题。核心D将通过协商和协作支持调查人员，领导进行中的工作会议，以及开发和维护与设计和方法有关的集中资源。我们的设计和方法核心的一个重要目标是进行乳腺癌翻译生物统计学研究，促进新方法的运动 当前和未来项目的实践方法。该项目有四个具体目标。目标1侧重于指导和监督三个项目所使用的分析和方法的最明显的基本作用。AIM 2旨在促进和支持可能从初步工作或新的外部研究结论或政策发展中提出的辅助和后续研究，目的是从为执行所述三个项目而进行的大量和昂贵的数据收集工作中获得更多好处。在目标3中，研究人员提议就两个应用统计问题开展工作， 确定统计和生物统计领域的前沿发展，并进行必要的工作，以证明这些方法可以可行和实际地回答该计划中的项目遇到的方法学问题。AIM 4旨在致力于在计划项目和核心以及更广泛的UM其他小组之间建立集中的资源和协作桥梁，这些小组专注于翻译研究方法，以进一步增强我们将正确的方法应用于正确的问题的能力。核心D包括具有以下技能的经验丰富的人员：1)高级生物统计分析，包括多水平建模、潜在变量、缺失数据和因果推断；2) 患者和提供者的信念和态度、行为和生活质量的心理测量；3)调查方法；4)质量测量和实践概况；5)实验、准实验和观察性设计；6)管理大型管理和临床数据库的技术方面。

The Design and Methodology Core will assist investigators to design studies and to analyze data using a mixture of established and innovative techniques to examine questions related to influencing individualization of treatment for women with breast cancer. Core D will support investigators through consultation and collaboration, lead work-in-progress sessions, as well as development and maintenance of centralized resources related to design and methodology. An important goal of our Design and Methodology core is to conduct breast cancer translational biostatistical research, facilitating the movement of new methodological approaches into practice for current and future projects. The project has four specific aims. Aim 1 focuses on the most obvious essential role of directing and supervising the analysis and methods used by the three projects. Aim 2 is designed to promote and support ancillary and follow-on studies that might be suggested from the preliminary work, or new external research findings or policy developments, with the goal of providing additional benefits from the large and expensive data collection effort undertaken to carry out the three projects described. In Aim 3, the investigators propose to do work on two applied statistical problems, identifying cutting edge developments in statistical and biostatistical fields and doing the necessary work to demonstrate that these methods can feasibly and practically answer methodological problems encountered by the projects in this program. Aim 4, is designed to focus on building centralized resources and collaborative bridges, both within the Program projects and cores and more broadly to other groups at UM that are focusing on translational research methods to further enhance our ability to bring the right methods to apply to the right problems. Core D includes experienced personnel with skills in: 1) advanced biostatistical analysis including multilevel modeling, latent variables, missing data and causal inference; 2) psychometric measurement of patient and provider beliefs and attitudes, behaviors, and quality of life; 3) survey methodology; 4) quality measurement and practice profiling; 5) experimental, quasi-experimental and observational designs; 6) technical aspects of managing large administrative and clinical databases.