NINDS Stroke Trials Network - Regional Coordinating Center

描述（由申请人提供）：中风是一种常见的神经系统疾病，是一个日益严重的重大公共卫生问题。尽管死亡率正在下降，但它仍然是美国第四大死因。它仍然是导致残疾的主要原因，随着人口老龄化，预计受影响的人数将显著增加。该战略的使命是减轻中风等神经系统疾病的负担。NINDS资助的脑卒中试验通常有较长的启动时间和完成研究的延迟。需要一种更好的方法来进行更大规模的中风临床研究。本申请的主要目标是成为NINDS卒中试验网络中的区域协调卒中中心（RCC）。该网络的目的是加速和促进脑卒中治疗、预防和康复方面的科学进展的转化。通过网络进行这类研究将提高试验的效率和效果。进行中风研究的基础设施不需要随着每次新的试验而重新组织。加快审判启动和结束。临床和生物学数据的标准化也将有助于今后的工作。这种网络将加强协作，并将发挥试验设计孵化器的作用。此外，网络将拓宽进入

DESCRIPTION (provided by applicant): Stroke is a common neurological disease and is a growing major public health problem. Although mortality is declining, it remains the number 4 cause of death in the U.S. It is still a major cause of disability, and is expected to significantl grow in number of affected individuals with aging of the population. The mission of NINDS is to reduce the burden of neurological disease, such as stroke. NINDS funded stroke trials have often suffered from long start up time and delays in completing the research. A better way of conducting stroke clinical research on a larger scale is needed. The main objective of this application is to be a Regional Coordinating Stroke Center (RCC) in the NINDS Stroke Trials Network. The purpose of the network is to accelerate and facilitate translation of scientific advancement in stroke treatment, prevention and recovery. Performing such research through the network will introduce a higher degree of efficiency and effectiveness in conducting the trials. The infrastructure to conduct stroke research will not need to be reorganized with every new trial. Trials will be initiated and completed faster. Standardization of clinical and biologica data will also be useful for future work. Enhanced collaboration will result from such a network, and will function as an incubator for trial design. In addition, the network will broaden access to subjects in the acute phase, prevention, and recovery periods. The University of Minnesota and its stroke program are uniquely qualified to serve a Regional Coordinating Center. It has access to a broad set of academic researchers relevant for this field, with depth in various domains of clinical research. It can also draw on the experience of implementing research network, as a current member in the NINDS Neurological Emergency Research Network (NETT). The leaders for this application and of the program are experienced in stroke clinical research, research through networks, and are experts in the subject matter. The various specialties needed to collaborate for successful implementation of the trials are already aligned administratively in collaborative units beyond traditional departments. Overall, the current stroke program at the University of Minnesota is an excellent candidate for leading an RCC.