NINDS Stroke Trials Network - Regional Coordinating Center

描述(申请人提供)：中风是一种常见的神经疾病，是一个日益严重的公共卫生问题。虽然死亡率正在下降，但它仍然是美国的第四大死因。它仍然是致残的主要原因，预计随着人口老龄化，受影响的人数将显著增加。NINDS的使命是减轻中风等神经系统疾病的负担。NINDS资助的中风试验经常受到启动时间长和完成研究延迟的影响。需要一种更好的方式来进行更大规模的中风临床研究。该应用程序的主要目标是成为NINDS卒中试验网络中的一个区域协调卒中中心(RCC)。该网络的目的是加速和促进中风治疗、预防和康复方面的科学进步的转化。通过网络进行这种研究将在进行试验时带来更高的效率和效力。进行中风研究的基础设施不需要随着每一项新的试验而进行重组。启动和完成试验的速度将更快。临床和生物学数据的标准化也将对未来的工作有用。这样一个网络将加强合作，并将作为试验设计的孵化器。此外，该网络将扩大访问 受试者处于急性期、防御期和恢复期。明尼苏达大学及其中风项目是唯一有资格为地区协调中心服务的机构。它可以接触到与这一领域相关的广泛的学术研究人员，在临床研究的各个领域都有深度。作为NINDS神经急诊研究网络(NETT)的当前成员，它还可以借鉴实施研究网络的经验。这一应用程序和该计划的领导者在中风临床研究和通过网络进行研究方面经验丰富，并且是该主题的专家。为成功实施试验而进行协作所需的各种专业已经在传统部门以外的协作单位进行了行政协调。总体而言，明尼苏达大学目前的中风项目是领导RCC的绝佳人选。

DESCRIPTION (provided by applicant): Stroke is a common neurological disease and is a growing major public health problem. Although mortality is declining, it remains the number 4 cause of death in the U.S. It is still a major cause of disability, and is expected to significantl grow in number of affected individuals with aging of the population. The mission of NINDS is to reduce the burden of neurological disease, such as stroke. NINDS funded stroke trials have often suffered from long start up time and delays in completing the research. A better way of conducting stroke clinical research on a larger scale is needed. The main objective of this application is to be a Regional Coordinating Stroke Center (RCC) in the NINDS Stroke Trials Network. The purpose of the network is to accelerate and facilitate translation of scientific advancement in stroke treatment, prevention and recovery. Performing such research through the network will introduce a higher degree of efficiency and effectiveness in conducting the trials. The infrastructure to conduct stroke research will not need to be reorganized with every new trial. Trials will be initiated and completed faster. Standardization of clinical and biologica data will also be useful for future work. Enhanced collaboration will result from such a network, and will function as an incubator for trial design. In addition, the network will broaden access to subjects in the acute phase, prevention, and recovery periods. The University of Minnesota and its stroke program are uniquely qualified to serve a Regional Coordinating Center. It has access to a broad set of academic researchers relevant for this field, with depth in various domains of clinical research. It can also draw on the experience of implementing research network, as a current member in the NINDS Neurological Emergency Research Network (NETT). The leaders for this application and of the program are experienced in stroke clinical research, research through networks, and are experts in the subject matter. The various specialties needed to collaborate for successful implementation of the trials are already aligned administratively in collaborative units beyond traditional departments. Overall, the current stroke program at the University of Minnesota is an excellent candidate for leading an RCC.