A new experimental genetic model of epilepsy: seizures and enhanced cognition
一种新的癫痫实验遗传模型:癫痫发作和认知增强
基本信息
- 批准号:8442829
- 负责人:
- 金额:$ 33.04万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2012
- 资助国家:美国
- 起止时间:2012-03-15 至 2017-02-28
- 项目状态:已结题
- 来源:
- 关键词:AddressAffectAgingAlzheimer&aposs DiseaseAttenuatedBiological Neural NetworksBrainCell FractionationCellsCellular StressCognitionCognition DisordersCognitiveCreutzfeldt-Jakob SyndromeDataDepressed moodDevelopmentDisinhibitionDouble-Stranded RNAElectroencephalographyEpilepsyEquilibriumEventExperimental GeneticsFrequenciesGene MutationGeneticGenetic ModelsGlutamatesGlutamineHippocampus (Brain)HomeostasisHuntington DiseaseIn VitroInterferonsKainic AcidLeadLearningLong-Term DepressionLong-Term PotentiationMeasuresMediatingMediator of activation proteinMemoryMemory LossMental DepressionMessenger RNAMolecularMusNeuronsNitric OxideParkinson DiseasePathway interactionsPerformancePeriodicityPhosphorylationPhysiologic pulsePopulationProcessProtein DephosphorylationPsyche structureReactive Oxygen SpeciesResistanceRoleRunawaySeizuresSeriesSignal TransductionSliceSourceStatus EpilepticusSynapsesSynaptic TransmissionSynaptic plasticityTestingTimeTranslationsVertebratesVirusVirus Diseasescognitive functioncomputerized data processingdesigneIF-2 Kinaseextracellularin vivoinhibitor/antagonistinterdisciplinary approachneuronal excitabilityneuropathologyneutralizing antibodypreventrelating to nervous systemresearch studyresponsesynaptic inhibitiontransmission process
项目摘要
DESCRIPTION (provided by applicant): The brain's cognitive functions derive from the coordinated interactions of large numbers of neurons that are widely distributed throughout the brain. Although seizure activity can be driven by hyperexcitable oscillatory networks, these transient synchronizations of neuronal discharges appear also to be involved in memory consolidation. Thus, a fundamental, yet unresolved, question is how this finely-tuned coordination of activity is achieved. We propose to use a multidisciplinary approach to study a new experimental genetic model of epilepsy in which seizures and enhanced cognition co-exist. This study will help to define the molecular and cellular mechanisms underlying both memory formation and brain rhythmicity. In addition, it could lead to the development of new treatments for conditions associated with memory loss such as aging, Alzheimer's disease, and Huntington's disease, all conditions where PKR activity is abnormally elevated and GABAergic synaptic transmission is altered.
描述(由申请人提供):大脑的认知功能源自广泛分布在整个大脑中的大量神经元的协调相互作用。虽然癫痫发作活动可以由过度兴奋的振荡网络驱动,但这些神经元放电的瞬时同步似乎也参与记忆巩固。因此,一个根本但尚未解决的问题是如何实现这种精细调整的活动协调。我们建议使用多学科的方法来研究一个新的癫痫发作和增强认知共存的实验遗传模型。这项研究将有助于确定记忆形成和脑节律性的分子和细胞机制。此外,它可能导致开发新的治疗方法,用于与记忆丧失相关的疾病,如衰老、阿尔茨海默病和亨廷顿病,所有这些疾病都是PKR活性异常升高和GABA能突触传递改变的疾病。
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
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Mauro Costa-Mattioli其他文献
Mauro Costa-Mattioli的其他文献
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Unraveling gut-microbiome-brain interactions in neurodevelopmental disorders
揭示神经发育障碍中肠道-微生物-大脑的相互作用
- 批准号:
10390737 - 财政年份:2021
- 资助金额:
$ 33.04万 - 项目类别:
The integrated stress response in cognitive disorders
认知障碍中的综合应激反应
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10393550 - 财政年份:2012
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$ 33.04万 - 项目类别:
The integrated stress response in cognitive disorders
认知障碍中的综合应激反应
- 批准号:
10156715 - 财政年份:2012
- 资助金额:
$ 33.04万 - 项目类别:
A new experimental genetic model of epilepsy: seizures and enhanced cognition
一种新的癫痫实验遗传模型:癫痫发作和认知增强
- 批准号:
8610362 - 财政年份:2012
- 资助金额:
$ 33.04万 - 项目类别:
A new experimental genetic model of epilepsy: seizures and enhanced cognition
一种新的癫痫实验遗传模型:癫痫发作和认知增强
- 批准号:
8304789 - 财政年份:2012
- 资助金额:
$ 33.04万 - 项目类别:
A new experimental genetic model of epilepsy: seizures and enhanced cognition
一种新的癫痫实验遗传模型:癫痫发作和认知增强
- 批准号:
8999020 - 财政年份:2012
- 资助金额:
$ 33.04万 - 项目类别:
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