Role of endocrine-disrupting chemicals and social stress on perinatal outcomes

内分泌干​​扰化学物质和社会压力对围产期结局的作用

• 批准号: 8729704
• 负责人: Ami R Zota
• 金额: $ 24.89万
• 依托单位: GEORGE WASHINGTON UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2013
• 资助国家: 美国
• 起止时间: 2013-09-25 至 2016-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8729704
• 关键词: Address; Affect; Animals; Attention; Binding; Biological; Biological Markers; Biometry; Birth; Blood; Blood Pressure; California; Carrier Proteins; Cell Aging; Cell Extracts; Chemicals; Chronic Disease; Chronic stress; DNA; Data; Development Plans; Ecology; Endocrine; Endocrine Disruptors; Environmental Epidemiology; Environmental Exposure; Environmental Health; Environmental Impact; Environmental Pollutants; Environmental Risk Factor; Epidemiologic Methods; Epidemiology; Evaluation; Exposure to; Face; Faculty; Fetal Development; Flame Retardants; Foundations; Future; Goals; Health; Health Policy; Human; Hypertension induced by pregnancy; Institution; Investigation; Knowledge; Learning; Length; Leukocytes; Linear Regressions; Link; Longitudinal Studies; Low Birth Weight Infant; Measures; Mediating; Mentors; Mentorship; Metabolism; Methods; Metric; Neighborhoods; Outcome; Parents; Pathway interactions; Patient Self-Report; Perinatal; Phase; Physiological; Policies; Population; Positioning Attribute; Prealbumin; Predisposition; Pregnancy; Pregnancy Complications; Pregnancy Outcome; Pregnant Women; Premature Birth; Process; Psychosocial Factor; Psychosocial Stress; Public Health; Questionnaires; Regression Analysis; Reproductive Biology; Reproductive Health; Research; Research Infrastructure; Research Personnel; Role; San Francisco; Science; Scientist; Social Conditions; Social status; Stress; Structure; Sum; System; Telomere Shortening; Thyroid Gland; Thyroid Hormones; Thyrotropin; Thyroxine; Training; Universities; Vulnerable Populations; Woman; Work; Workplace; abstracting; analytical tool; biological adaptation to stress; career development; critical period; disorder risk; exposed human population; health disparity; human study; improved; innovation; insight; maternal serum; perinatal health; phenyl ether; programs; racial and ethnic; reproductive; reproductive epidemiology; response; social; social health determinants; social stress; socioeconomics; stressor; telomere

Project Summary/Abstract The goal of my K99/R00 career development plan is to launch an independent research program in reproductive and environmental epidemiology of endocrine-disrupting chemicals (EDCs) which includes evaluating social determinants of health that may affect overlapping biologic pathways. To accomplish this goal, I will enhance my expertise in environmental health sciences with didactic and hands-on training in reproductive biology, social epidemiology/stress science, and environmental epidemiologic methods. This specialized training will allow me to achieve my long term goal of becoming an independent academic investigator and offering new insights on the cumulative impacts of environmental and social factors on reproductive health. The primary goal of my research plan is to evaluate the independent effects of polybrominated diphenyl ethers (PBDEs) and psychosocial stress on thyroid hormone disruption and consequent perinatal outcomes among a population of socioeconomically and racially diverse pregnant women. This work is particularly innovative as both PBDEs and psychosocial stress can impact the thyroid system, suggesting a biologic plausibility for interaction, however the two exposures have never been examined simultaneously in a human study. During the K99 mentored phase, under the primary mentorship of Dr. Tracey Woodruff, I will use innovative measures to characterize biologically-relevant exposures to PBDEs and psychosocial stress and their effects on thyroid hormone disruption. Exposure to PBDEs will be assessed using both PBDE congeners as well as their hydroxylated metabolites (OH-PBDEs). Psychosocial stress will be evaluated with subjective measures of stress and telomere length, a biomarker of cellular aging that is influenced by psychosocial stress. In the independent phase, I will apply this knowledge to investigate the independent effects of PBDEs and psychosocial stress on adverse perinatal outcomes, such as gestational hypertension, preterm birth, and low birth weight, and assess whether these effects are mediated via the thyroid system. The integration of this work will enable me to develop the necessary methodological and biological frameworks to examine the combined, and potentially synergistic, effects of environmental and psychosocial factors on perinatal outcomes in future R01 studies. I am well positioned to accomplish these goals at the University of California, San Francisco, a highly respected research institution, with a strong environmental reproductive health program, a world-renowned faculty with expertise in psychosocial stress, and an extensive biomedical infrastructure. My primary mentor and co-mentors in reproductive sciences, environmental epidemiology, health disparities, stress science, and biostatistics will guide the process whereby I learn the methods that are required to accomplish the goals set forth in this proposal. This project represents the cutting-edge of health disparities and environmental health research and seeks to answer critical scientific as well as policy-relevant questions for improving the health of vulnerable populations who often face disproportionate and elevated exposures to multiple chemical and non-chemical stressors.

项目摘要/摘要 我的K99/R00职业发展计划的目标是启动一个独立的研究计划 内分泌干​​扰化学物质（EDC）的生殖和环境流行病学包括 评估可能影响重叠生物学途径的健康决定因素。实现这一目标 目标，我将通过教学和动手培训来增强我在环境健康科学方面的专业知识 生殖生物学，社会流行病学/压力科学和环境流行病学方法。这 专业培训将使我实现成为独立学术的长期目标 研究者并提供有关环境和社会因素累积影响的新见解 生殖健康。 我的研究计划的主要目标是评估多溴二苯基的独立效果 甲状腺激素破坏以及随之而来的围产期预后，以太剂（PBDE）和社会心理压力 在社会经济和种族多元化的孕妇中。这项工作特别是 创新的PBDE和社会心理压力都会影响甲状腺系统，这表明生物学 相互作用的合理性，但是这两种暴露从未在人类中同时进行检查 学习。在K99指导阶段，在Tracey Woodruff博士的主要指导下，我将使用 创新措施以表征与PBDE和社会心理压力的生物学相关的暴露和 它们对甲状腺激素破坏的影响。将使用两位PBDE同类人员评估暴露于PBDES 以及它们的羟基化代谢产物（OH-PBDES）。主观会评估社会心理压力 压力和端粒长度的度量，这是受社会心理压力影响的细胞衰老的生物标志物。 在独立阶段，我将应用这些知识来研究PBDE和 对不良周围结局的社会心理压力，例如妊娠高血压，早产和低 出生体重，并评估这些作用是否是通过甲状腺系统介导的。整合 工作将使我能够开发必要的方法论和生物学框架来检查 环境和社会心理因素对围产期结局的结合且有可能协同的影响 在未来的R01研究中。我有能力在加利福尼亚大学SAN实现这些目标 弗朗西斯科（Francisco）是一家备受推崇的研究机构，具有强大的环境生殖健康计划， 世界知名的教师在心理压力方面具有专业知识和广泛的生物医学基础设施。我的 生殖科学，环境流行病学，健康差异，健康差异 压力科学和生物统计学将指导我学习所需方法的过程 完成此提案中规定的目标。该项目代表着健康差异的前沿 以及环境健康研究，并试图回答关键的科学以及与政策相关的问题 为了改善易受伤害的人群的健康 多种化学和非化学应激源。