权益分类	功能权益	普通用户	{{item.name}}会员
{{category.name}}	{{benefitItem.name}}

Role of endocrine-disrupting chemicals and social stress on perinatal outcomes

内分泌干扰化学物质和社会压力对围产期结局的作用

基本信息

批准号：
8913174
负责人：
Ami R Zota
金额：
$ 24.9万
依托单位：
GEORGE WASHINGTON UNIVERSITY
依托单位国家：
美国
项目类别：
财政年份：
2013
资助国家：
美国
起止时间：
2013-09-25 至 2017-08-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/8913174
关键词：
Address Affect Animals Attention Binding Biological Biological Markers Biometry Birth Blood Blood Pressure California Carrier Proteins Cell Aging Cell Extracts Chemicals Chronic Disease Chronic stress DNA Data Development Plans Ecology Endocrine Endocrine Disruptors Environmental Epidemiology Environmental Exposure Environmental Health Environmental Impact Environmental Pollutants Environmental Risk Factor Epidemiologic Methods Epidemiology Evaluation Exposure to Face Faculty Fetal Development Flame Retardants Foundations Future Goals Health Health Policy Human Institution Investigation Knowledge Learning Length Leukocytes Linear Regressions Link Longitudinal Studies Low Birth Weight Infant Measures Mediating Mentors Mentorship Metabolism Methods Neighborhoods Outcome Parents Pathway interactions Patient Self-Report Phase Physiological Policies Population Positioning Attribute Prealbumin Predisposition Pregnancy Pregnancy Complications Pregnancy Outcome Pregnant Women Premature Birth Process Psychosocial Factor Psychosocial Stress Public Health Questionnaires Regression Analysis Reproductive Biology Reproductive Health Research Research Infrastructure Research Personnel Role San Francisco Science Scientist Social Conditions Social status Stress Structure Sum System Telomere Shortening Thyroid Gland Thyroid Hormones Thyrotropin Thyroxine Training Universities Vulnerable Populations Woman Work abstracting analytical tool biological adaptation to stress career development collaborative environment critical period disorder risk exposed human population health disparity human study improved innovation insight maternal serum perinatal health perinatal outcomes phenyl ether pregnancy hypertension programs racial and ethnic reproductive reproductive epidemiology response social social health determinants social stress socioeconomic disparity socioeconomics stressor telomere

项目摘要

Project Summary/Abstract The goal of my K99/R00 career development plan is to launch an independent research program in reproductive and environmental epidemiology of endocrine-disrupting chemicals (EDCs) which includes evaluating social determinants of health that may affect overlapping biologic pathways. To accomplish this goal, I will enhance my expertise in environmental health sciences with didactic and hands-on training in reproductive biology, social epidemiology/stress science, and environmental epidemiologic methods. This specialized training will allow me to achieve my long term goal of becoming an independent academic investigator and offering new insights on the cumulative impacts of environmental and social factors on reproductive health. The primary goal of my research plan is to evaluate the independent effects of polybrominated diphenyl ethers (PBDEs) and psychosocial stress on thyroid hormone disruption and consequent perinatal outcomes among a population of socioeconomically and racially diverse pregnant women. This work is particularly innovative as both PBDEs and psychosocial stress can impact the thyroid system, suggesting a biologic plausibility for interaction, however the two exposures have never been examined simultaneously in a human study. During the K99 mentored phase, under the primary mentorship of Dr. Tracey Woodruff, I will use innovative measures to characterize biologically-relevant exposures to PBDEs and psychosocial stress and their effects on thyroid hormone disruption. Exposure to PBDEs will be assessed using both PBDE congeners as well as their hydroxylated metabolites (OH-PBDEs). Psychosocial stress will be evaluated with subjective measures of stress and telomere length, a biomarker of cellular aging that is influenced by psychosocial stress. In the independent phase, I will apply this knowledge to investigate the independent effects of PBDEs and psychosocial stress on adverse perinatal outcomes, such as gestational hypertension, preterm birth, and low birth weight, and assess whether these effects are mediated via the thyroid system. The integration of this work will enable me to develop the necessary methodological and biological frameworks to examine the combined, and potentially synergistic, effects of environmental and psychosocial factors on perinatal outcomes in future R01 studies. I am well positioned to accomplish these goals at the University of California, San Francisco, a highly respected research institution, with a strong environmental reproductive health program, a world-renowned faculty with expertise in psychosocial stress, and an extensive biomedical infrastructure. My primary mentor and co-mentors in reproductive sciences, environmental epidemiology, health disparities, stress science, and biostatistics will guide the process whereby I learn the methods that are required to accomplish the goals set forth in this proposal. This project represents the cutting-edge of health disparities and environmental health research and seeks to answer critical scientific as well as policy-relevant questions for improving the health of vulnerable populations who often face disproportionate and elevated exposures to multiple chemical and non-chemical stressors.

项目总结/文摘

项目成果

期刊论文数量（7）

专著数量（0）

科研奖励数量（0）

会议论文数量（0）

专利数量（0）

Cross-sectional Associations between Exposure to Persistent Organic Pollutants and Leukocyte Telomere Length among U.S. Adults in NHANES, 2001-2002.

DOI：
10.1289/ehp.1510187
发表时间：
2016-05
期刊：
Environmental health perspectives
影响因子：
10.4
作者：
Mitro SD;Birnbaum LS;Needham BL;Zota AR
通讯作者：
Zota AR

Consumer Product Chemicals in Indoor Dust: A Quantitative Meta-analysis of U.S. Studies.

DOI：
10.1021/acs.est.6b02023
发表时间：
2016-10-04
期刊：
ENVIRONMENTAL SCIENCE & TECHNOLOGY
影响因子：
11.4
作者：
Mitro, Susanna D.;Dodson, Robin E.;Singla, Veena;Adarnkiewicz, Gary;Elmi, Angelo F.;Tilly, Monica K.;Zota, Ami R.
通讯作者：
Zota, Ami R.

The environmental injustice of beauty: framing chemical exposures from beauty products as a health disparities concern.