Childhood health disparities: exploration of prenatal exposures in primary teeth

儿童期健康差异：乳牙产前暴露的探索

• 批准号: 8429805
• 负责人: Andrea E Cassidy-Bushrow
• 金额: $ 25.36万
• 依托单位: HENRY FORD HEALTH SYSTEM
• 依托单位国家: 美国
• 财政年份: 2012
• 资助国家: 美国
• 起止时间: 2012-12-01 至 2014-11-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8429805
• 关键词: 2 year old; Ablation; Accounting; Adult; Age; Allergic; Allergic Disease; Area; Arsenic; Asthma; Barker Hypothesis; Birth; Birth Weight; Cadmium; Child; Child health care; Childhood; Chronic Disease; County; Coupled; Data; Development; Early identification; Early treatment; Environment; Fetal Development; Fetus; Future; Geographic Locations; Gestational Age; Goals; Health; Health Policy; Health system; Human; Hypersensitivity; Image; Immune system; Industry; Lasers; Lead; Life; Longitudinal Studies; Manganese; Maps; Mass Spectrum Analysis; Measures; Mercury; Metal exposure; Metals; Methods; Minority; Outcome; Participant; Phenotype; Plant Roots; Plasma; Pollution; Predisposition; Premature Birth; Prevention strategy; Public Health; Race; Recruitment Activity; Reliance; Research Personnel; Role; Sampling; Socioeconomic Status; Source; Time; Tooth structure; Toxic Environmental Substances; Toxicant exposure; Woman; atopy; body system; cohort; deciduous tooth; early childhood; early life exposure; fetal; fetal lead exposure; health disparity; high risk; improved; interest; metropolitan; novel; novel strategies; postnatal; prenatal; prenatal exposure; prenatal risk factor; public health relevance; racial difference; segregation; social; socioeconomics; suburb; theories; toxicant; trait

DESCRIPTION (provided by investigator): Differences in prenatal exposures may account for some of the racial disparities observed in health outcomes; however, studies have been hampered by a lack of a reliable means of examining such retrospective exposures. A novel method, elemental bio-imaging of human primary teeth with laser ablation-inductively coupled plasma-mass spectrometry (LA-ICP-MS), will be used to measure metal exposures in naturally sheed teeth of an established birth cohort. This approach not only quantifies exposure but also estimates the timing of the exposure (i.e. within trimester). We hypothesize there are identifiable critical windows of exposure aligned with gestational development of key organ systems that are specific for different child health outcomes. The proposed project builds on extant data collected through the racially and socioeconomically diverse Wayne County Health, Environment, Allergy and Asthma Longitudinal Study (WHEALS) birth cohort conducted between 2003 and 2007 in Detroit, MI and the surrounding suburban regions. From a subset of active WHEALS participants, 250 naturally shed primary teeth (230 unique children) will be collected and 5 metals (lead, cadmium, manganese, mercury, arsenic) will be measured with LA-ICP-MS. Our outcomes of interest are two traits demonstrating substantial racial disparities: birth weight and allergic disease measures at age 2 years. Our aims are to (1) examine if there are racial differences in early-life metal toxicant exposures; (2) examine if trimester-specific exposures to metal toxicants are associated with birth weight; and (3) examine if early-life exposures to metal toxicants are associated with allergic disease at age 2. Information gained by the proposed study may guide public health policy, improve prevention strategies, and lead to earlier identification and treatment of high-risk children with the overall goal to reduce health disparitis and improve the publics' heath.

描述（由研究者提供）：产前暴露的差异可能是在健康结果中观察到的一些种族差异的原因;然而，由于缺乏可靠的方法来检查这种回顾性暴露，研究受到了阻碍。一种新的方法，激光烧蚀电感耦合等离子体质谱（LA-ICP-MS）的人类乳牙元素生物成像，将被用来测量金属暴露在一个既定的出生队列的自然脱落的牙齿。这种方法不仅量化了暴露，而且还估计了暴露的时间（即在三个月内）。我们假设有可识别的 暴露的关键窗口与对不同儿童健康结果具有特异性的关键器官系统的妊娠期发育相一致。拟议的项目建立在通过种族和社会经济多样化的韦恩县健康，环境，过敏和哮喘纵向研究（WHEALS）出生队列收集的现有数据的基础上，该研究于2003年至2007年在底特律，密歇根州和周边郊区进行。从一个积极的WHEALS参与者的子集，250自然脱落的乳牙（230个独特的儿童）将被收集和5金属（铅，镉，锰，汞，砷）将与LA-ICP-MS测量。我们感兴趣的结果是两个性状表现出实质性的种族差异：出生体重和过敏性疾病的措施，在2岁。我们的目的是（1）检查早期金属毒物暴露是否存在种族差异;（2）检查特定孕期金属毒物暴露是否与出生体重相关;（3）检查早期金属毒物暴露是否与2岁时的过敏性疾病相关。本研究所获得的信息可以指导公共卫生政策，改进预防策略，并导致早期识别和治疗高危儿童，以减少健康性肠炎，提高公众的健康。