Mentoring and Patient Oriented Research in Asthma

描述(由申请人提供) 迪特博士是约翰·霍普金斯大学医学院的医学副教授，他在彭博公共卫生学院担任流行病学和环境健康科学的联合教授。自从加入教职以来，迪埃特博士已经指导了20多名实习生，其中包括14名博士后研究员。除了极少数例外，他的学员继续从事高生产率的学术生涯，获得荣誉并获得NIH拨款支持(NRSA、K23、R21、R01 U01和项目负责人的项目拨款)。他职业生涯的大部分时间都致力于进行研究、介绍和传播研究成果，并建立了来自NIH和其他来源的稳定的研究资金基础。迪埃特博士职业生涯的重点一直是以患者为中心的哮喘研究，特别是基于种族的医疗保健差异和疾病的环境决定因素。这项K24提案的主要目的是减轻临床和行政职责，以扩大POR计划，并将更多的时间和精力投入到当前和未来的受训人员身上。因此，这项提案的总体目标是：目标1：提高候选人在面向患者的研究中指导临床医生科学家的能力；目标2：扩大候选人的临床研究计划，向为他和他的导师创造新的科学机会的方向发展。 迪特博士是哮喘饮食项目的负责人，该奖项旨在研究饮食对儿童哮喘易感性的影响，同时也是霍普金斯发现项目的联合负责人，该项目研究过敏原和污染物引发炎症和氧化应激的机制。这些项目是他目前的学员的研究之家。这些多项目项目汇集了过敏学家、肺病学家、成人和儿科医学、生物统计学家、流行病学家、环境卫生工程师和其他人的广泛科学专业知识。虽然现在有大量证据表明室内环境在儿童哮喘中的作用，但关于过敏原和污染物可能引发市中心成年人炎症和氧化应激的生物机制的证据不足。由于成人哮喘患者承受着大多数(90%)可归因于这种疾病的死亡，治疗不充分，特别是在环境控制领域。这项提案的一个主要焦点将是将目前的研究项目从市中心的儿童扩大到也包括市中心的成年人。拟议的100名患有哮喘的市中心成年人队列将检查室内颗粒物引发氧化应激和炎症的程度。随着研究计划的扩大，候选人将为未来以家庭为基础的多组分环境干预措施在成人中的试验奠定基础，这些目标与当前被辅导者的职业目标一致，并将为未来对成人哮喘有研究兴趣的被辅导者奠定基础。

DESCRIPTION (provided by applicant) Dr. Diette is Associate Professor of Medicine at the Johns Hopkins University School of Medicine, where he has joint appointments in Epidemiology and Environmental Health Sciences at the Bloomberg School of Public Health. Since joining the faculty, Dr. Diette has served as mentor to more than 20 trainees, including 14 postdoctoral fellows. With rare exception, his mentees have gone on to highly productive academic careers, garnering honors and receiving NIH grant support (NRSA, K23, R21, R01 U01 and Project Leader on program grants). The majority of his professional life has been dedicated to the conduct of research, presentation and dissemination of findings and establishing a steady base of research funding from the NIH and other sources. The focus of Dr. Diette's career has been on patient-oriented research in asthma, especially race-based health care disparities and environmental determinants of the disease. The main purpose of this K24 proposal is to provide relief from clinical and administrative duties in order to expand the POR program and dedicate additional time and energy to current and future trainees. Thus, the overall aims of this proposal are: Aim 1: To enhance the candidate's capacity to mentor clinician scientists in patient-oriented research; and Aim 2: To expand the candidate's clinical research program in directions that create new scientific opportunities for him and his mentees. Dr. Diette directs the ASTHMA-DIET, a program award examining how diet contributes to asthma susceptibility in children and co-directs the Hopkins DISCOVER program, which investigates mechanisms by which allergens and pollutants provoke inflammation and oxidative stress. These programs are the research homes for his current mentees. These multi-project programs bring together broad scientific expertise from allergists, pulmonologists, adult and pediatric medicine, biostatisticians, epidemiologists, environmental health engineers and others. While substantial evidence now exists for the role of the indoor environment in pediatric asthma, there is insufficient evidence of the biologic mechanisms by which allergens and pollutants may provoke inflammation and oxidative stress in inner city adults. As adults with asthma endure the majority (90%) of mortality attributed to the disease, treatments are inadequate, especially in the area of environmental control. A major focus of this proposal will be to expand the present research program from inner city children to also include inner city adults. The proposed cohort of 100 inner city adults with asthma will examine the extent to which indoor particulate matter provokes oxidative stress and inflammation. With this expansion in the research program, the candidate will provide the foundation for future trials in adults of home-based multi- component environmental interventions, goals which are concordant with the career goals of current mentees and will establish the infrastructure for future mentees with a research interest in adult asthma.