Mentoring and Patient Oriented Research in Asthma

描述（由申请人提供） 博士Diette是约翰霍普金斯大学医学院的医学副教授，在那里他在彭博公共卫生学院的流行病学和环境健康科学联合任命。自加入学院以来，Diette博士已担任20多名学员的导师，其中包括14名博士后研究员。 除了极少数例外，他的学员已经进入了富有成效的学术生涯，获得了荣誉并获得了NIH的资助支持（NRSA，K23，R21，R 01 U 01和项目负责人项目赠款）。他的大部分职业生涯一直致力于研究，介绍和传播的结果，并建立了一个稳定的基础，从美国国立卫生研究院和其他来源的研究资金。Diette博士职业生涯的重点一直是以患者为导向的哮喘研究，特别是基于种族的卫生保健差异和疾病的环境决定因素。该K24提案的主要目的是减轻临床和行政职责，以扩大POR计划，并将更多的时间和精力用于当前和未来的学员。因此，该提案的总体目标是：目标1：提高候选人指导临床科学家进行以患者为导向的研究的能力;目标2：扩大候选人的临床研究计划，为他和他的学员创造新的科学机会。 博士Diette指导ASTHMA-DIET，这是一个研究饮食如何导致儿童哮喘易感性的项目，并共同指导霍普金斯发现项目，该项目研究过敏原和污染物引起炎症和氧化应激的机制。这些项目是他目前学员的研究之家。这些多项目计划汇集了来自过敏症专家，肺病学家，成人和儿科医学，生物统计学家，流行病学家，环境卫生工程师等的广泛科学专业知识。虽然现在有大量证据表明室内环境在儿童哮喘中的作用，但过敏原和污染物可能引起内城成年人炎症和氧化应激的生物学机制的证据不足。 由于成人哮喘患者承受了大多数（90%）归因于疾病的死亡率，治疗是不够的，特别是在环境控制领域。 这项建议的一个主要重点将是扩大目前的研究计划，从内城儿童也包括内城成人。这项由100名患有哮喘的内城成年人组成的队列研究将研究室内颗粒物引起氧化应激和炎症的程度。 随着研究计划的扩展，候选人将为未来在成人中进行基于家庭的多组分环境干预试验奠定基础，这些目标与当前学员的职业目标一致，并将为未来对成人哮喘有研究兴趣的学员建立基础设施。

DESCRIPTION (provided by applicant) Dr. Diette is Associate Professor of Medicine at the Johns Hopkins University School of Medicine, where he has joint appointments in Epidemiology and Environmental Health Sciences at the Bloomberg School of Public Health. Since joining the faculty, Dr. Diette has served as mentor to more than 20 trainees, including 14 postdoctoral fellows. With rare exception, his mentees have gone on to highly productive academic careers, garnering honors and receiving NIH grant support (NRSA, K23, R21, R01 U01 and Project Leader on program grants). The majority of his professional life has been dedicated to the conduct of research, presentation and dissemination of findings and establishing a steady base of research funding from the NIH and other sources. The focus of Dr. Diette's career has been on patient-oriented research in asthma, especially race-based health care disparities and environmental determinants of the disease. The main purpose of this K24 proposal is to provide relief from clinical and administrative duties in order to expand the POR program and dedicate additional time and energy to current and future trainees. Thus, the overall aims of this proposal are: Aim 1: To enhance the candidate's capacity to mentor clinician scientists in patient-oriented research; and Aim 2: To expand the candidate's clinical research program in directions that create new scientific opportunities for him and his mentees. Dr. Diette directs the ASTHMA-DIET, a program award examining how diet contributes to asthma susceptibility in children and co-directs the Hopkins DISCOVER program, which investigates mechanisms by which allergens and pollutants provoke inflammation and oxidative stress. These programs are the research homes for his current mentees. These multi-project programs bring together broad scientific expertise from allergists, pulmonologists, adult and pediatric medicine, biostatisticians, epidemiologists, environmental health engineers and others. While substantial evidence now exists for the role of the indoor environment in pediatric asthma, there is insufficient evidence of the biologic mechanisms by which allergens and pollutants may provoke inflammation and oxidative stress in inner city adults. As adults with asthma endure the majority (90%) of mortality attributed to the disease, treatments are inadequate, especially in the area of environmental control. A major focus of this proposal will be to expand the present research program from inner city children to also include inner city adults. The proposed cohort of 100 inner city adults with asthma will examine the extent to which indoor particulate matter provokes oxidative stress and inflammation. With this expansion in the research program, the candidate will provide the foundation for future trials in adults of home-based multi- component environmental interventions, goals which are concordant with the career goals of current mentees and will establish the infrastructure for future mentees with a research interest in adult asthma.