Domestic Indoor PM & Childhood Asthma Morbidity

国内室内PM

• 批准号: 8119047
• 负责人: GREGORY B DIETTE
• 金额: $ 44.32万
• 依托单位: JOHNS HOPKINS UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2010
• 资助国家: 美国
• 起止时间: 2010-08-01 至 2012-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8119047
• 关键词: Address; Adverse effects; Affect; African American; Air; Air Pollution; Allergens; Allergic; Animal Model; Asthma; Biological Markers; Blood; Breathing; Cells; Child; Childhood Asthma; Complement; Complex; Data; Disease; Dust; Environment; Environmental Exposure; Exhalation; Exposure to; Extrinsic asthma; Health; Health Policy; Home environment; Human; IgE; Indoor Air Quality; Inflammation; Inflammatory; Irrigation; Lead; Leukotriene E4; Life; Link; Low income; Measures; Minority; Morbidity - disease rate; Mus; Nasal Lavage Fluid; Neighborhoods; Nitric Oxide; Nose; Oxidative Stress; Oxidative Stress Pathway; Participant; Pathway interactions; Play; Pollution; Population; Predisposition; Recruitment Activity; Research; Research Personnel; Respiratory physiology; Role; Serum; Symptoms; System; Time; Urine; Variant; Vulnerable Populations; air cleaner; airway inflammation; base; boys; clinical effect; human subject; improved; inner city; member; pollutant; programs; research study; response; suburb; urinary

Asthma is a common disorder among children. Children with asthma have multiple and complex environmental exposures, including inhalable pollutants and allergens. The response to inhaled exposures is characterized by airway inflammation, and possibly by activation of oxidative stress pathways. In theU.S., the burden of asthma is enormous, with a disproportionate impact on vulnerable groups including young children, African-Americans and those living in the inner city. These most vulnerable people often inhabit an environment that has excessive outdoor pollution levels, as well as high levels of indoor allergens and pollutants. We plan to address the critical questions of the role of the indoor environment on childhood asthma, we propose a panel study of children living in urban neighborhoods enriched with African-American and lower income participants. This real world field-based study will complement the findings from Projects 2, 3 and 4, which will similarly examine the effects of PM and allergen, but in controlled settings using human subjects, animal models and cell systems. We will recruit atopic asthmatics, including those with and without sensitization to mouse allergen, as well as normal controls, to address the following Specific Aims: Aim 1 .A: To determine the contribution of indoor PM to day-to-day variation in lung function and asthma control, among inner city children with atopic asthma. Aim IB: To determine if higher indoor PM exposure is associatedwith biomarkers of inflammation and oxidative stress. Aim 2A: To determine if mouse IgE-positive asthmatics with high mouse allergen exposure have greater susceptibility to PMthan other atopic asthmatics (mouse IgE-negative and/or with low mouse allergen exposure). Aim 2.B: To determine if mouse IgE-positive asthmaticswith high mouse allergen exposure (> 0.5 ug/g of Mus m 1) have elevated biomarkers of inflammation and oxidative stress in response to PM compared to those who are mouse IgE-E negative or who have low mouse allergen exposure..

哮喘是儿童常见疾病。哮喘的孩子有多个复杂的 环境暴露，包括吸入污染物和过敏原。对吸入暴露的反应是 以气道炎症以及氧化应激途径的激活为特征。在theu.s.中 哮喘的负担很大，对包括年轻的弱势群体产生了不成比例的影响 儿童，非裔美国人和居住在内城的人。这些最脆弱的人经常居住 室外污染水平过高的环境以及高水平的室内过敏原和 污染物。 我们计划解决室内环境在童年哮喘中的作用的关键问题，我们 提出了一项针对居住在城市社区中的儿童的小组研究 收入参与者。这项基于世界现场的研究将补充项目2、3和4的发现， 它将类似地检查PM和过敏原的影响，但在使用人类受试者的受控设置中， 动物模型和细胞系统。我们将招募原住民哮喘患者，包括有或没有的哮喘患者 对小鼠过敏原以及正常对照的敏化，以解决以下特定目的： 目标1 .A：确定室内PM对肺功能和哮喘的日常变化的贡献 在城市内特应性哮喘的儿童中。 目的IB：确定较高的室内PM暴露是否与炎症和 氧化应激。 AIM 2A：确定小鼠IgE阳性哮喘患者是否具有高小鼠过敏原暴露的哮喘患者 对其他特应特应特应性哮喘的敏感性（小鼠IgE阴性和/或小鼠过敏原 接触）。 AIM 2.B：确定小鼠IgE阳性哮喘是否与高小鼠过敏原暴露（> 0.5 ug/g） MUS M 1）与PM相比，炎症和氧化应激的生物标志物升高 那些是老鼠IgE-e阴性或小鼠过敏原暴露的人。