Domestic Indoor PM & Childhood Asthma Morbidity

国内室内PM

• 批准号: 8119047
• 负责人: GREGORY B DIETTE
• 金额: $ 44.32万
• 依托单位: JOHNS HOPKINS UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2010
• 资助国家: 美国
• 起止时间: 2010-08-01 至 2012-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8119047
• 关键词: Address; Adverse effects; Affect; African American; Air; Air Pollution; Allergens; Allergic; Animal Model; Asthma; Biological Markers; Blood; Breathing; Cells; Child; Childhood Asthma; Complement; Complex; Data; Disease; Dust; Environment; Environmental Exposure; Exhalation; Exposure to; Extrinsic asthma; Health; Health Policy; Home environment; Human; IgE; Indoor Air Quality; Inflammation; Inflammatory; Irrigation; Lead; Leukotriene E4; Life; Link; Low income; Measures; Minority; Morbidity - disease rate; Mus; Nasal Lavage Fluid; Neighborhoods; Nitric Oxide; Nose; Oxidative Stress; Oxidative Stress Pathway; Participant; Pathway interactions; Play; Pollution; Population; Predisposition; Recruitment Activity; Research; Research Personnel; Respiratory physiology; Role; Serum; Symptoms; System; Time; Urine; Variant; Vulnerable Populations; air cleaner; airway inflammation; base; boys; clinical effect; human subject; improved; inner city; member; pollutant; programs; research study; response; suburb; urinary

Asthma is a common disorder among children. Children with asthma have multiple and complex environmental exposures, including inhalable pollutants and allergens. The response to inhaled exposures is characterized by airway inflammation, and possibly by activation of oxidative stress pathways. In theU.S., the burden of asthma is enormous, with a disproportionate impact on vulnerable groups including young children, African-Americans and those living in the inner city. These most vulnerable people often inhabit an environment that has excessive outdoor pollution levels, as well as high levels of indoor allergens and pollutants. We plan to address the critical questions of the role of the indoor environment on childhood asthma, we propose a panel study of children living in urban neighborhoods enriched with African-American and lower income participants. This real world field-based study will complement the findings from Projects 2, 3 and 4, which will similarly examine the effects of PM and allergen, but in controlled settings using human subjects, animal models and cell systems. We will recruit atopic asthmatics, including those with and without sensitization to mouse allergen, as well as normal controls, to address the following Specific Aims: Aim 1 .A: To determine the contribution of indoor PM to day-to-day variation in lung function and asthma control, among inner city children with atopic asthma. Aim IB: To determine if higher indoor PM exposure is associatedwith biomarkers of inflammation and oxidative stress. Aim 2A: To determine if mouse IgE-positive asthmatics with high mouse allergen exposure have greater susceptibility to PMthan other atopic asthmatics (mouse IgE-negative and/or with low mouse allergen exposure). Aim 2.B: To determine if mouse IgE-positive asthmaticswith high mouse allergen exposure (> 0.5 ug/g of Mus m 1) have elevated biomarkers of inflammation and oxidative stress in response to PM compared to those who are mouse IgE-E negative or who have low mouse allergen exposure..

哮喘是儿童中常见的疾病。儿童哮喘有多种复杂的 环境暴露，包括可吸入污染物和过敏原。对吸入暴露的反应是 其特征在于气道炎症，并且可能通过氧化应激途径的激活。在美国， 哮喘的负担是巨大的，对包括年轻人在内的弱势群体的影响不成比例 儿童，非洲裔美国人和那些住在市中心的人。这些最脆弱的人往往居住在一个 环境，有过度的室外污染水平，以及高水平的室内过敏原， 污染物 我们计划解决室内环境对儿童哮喘的作用这一关键问题， 我建议对生活在非洲裔美国人和低收入美国人聚居的城市社区的儿童进行一项小组研究。 收入参与者。这项基于真实的世界实地研究将补充项目2、3和4的研究结果， 其将类似地检查PM和过敏原的影响，但是在使用人类受试者的受控环境中， 动物模型和细胞系统。我们将招募特应性哮喘患者，包括有和没有 致敏小鼠过敏原，以及正常对照，以解决以下特定目的： 目的1.A：确定室内PM对肺功能和哮喘的日常变化的贡献 对照组，在患有特应性哮喘的内城儿童中。 目的IB：确定较高的室内PM暴露是否与炎症生物标志物相关， 氧化应激 目的2A：确定高小鼠变应原暴露的小鼠IgE阳性哮喘患者是否具有更大的 与其他特应性哮喘患者（小鼠IgE阴性和/或低小鼠过敏原）相比， 曝光）。 目的2.B：确定高小鼠变应原暴露（> 0.5 ug/g）的小鼠IgE阳性哮喘患者是否 小鼠m1）与小鼠m2相比， 小鼠IgE-E阴性或小鼠过敏原暴露低的人。