Improving translational understanding of the most abundant therapeutic target class

提高对最丰富的治疗靶点类别的转化理解

• 批准号: nhmrc : GNT1154434
• 负责人: Prof Patrick Sexton
• 金额: $ 88.83万
• 依托单位: Monash University
• 依托单位国家: 澳大利亚
• 项目类别: Research Fellowships
• 财政年份: 2019
• 资助国家: 澳大利亚
• 起止时间: 2019-01-01 至 无数据
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/improving-translational-understanding-target-class/1349139
• 关键词: Improving; translational; understanding; most; abundant

Many drugs act on a family of proteins in our body called G protein-coupled receptors (GPCRs). However, despite some notable successes, most of the attempts to make drugs that act on GPCRs have failed. Focusing on neuropsychiatric and metabolic disease, through establishment of world leading capability and a multi-disciplinary team of expert collaborators, my research will ask, what are the molecular features that make effective drugs that act on GPCRs?

许多药物作用于我们体内称为G蛋白偶联受体（GPCR）的蛋白质家族。然而，尽管取得了一些显著的成功，但大多数试图制造作用于GPCR的药物的尝试都失败了。专注于神经精神和代谢疾病，通过建立世界领先的能力和多学科的专家合作团队，我的研究将问，是什么分子特征使有效的药物作用于GPCR？