Probing the role of dynamics in protein modulation of GPCR phenotype

探讨动力学在 GPCR 表型蛋白质调节中的作用

• 批准号: DP210101504
• 负责人: Prof Patrick Sexton
• 金额: $ 45.38万
• 依托单位: Monash University
• 依托单位国家: 澳大利亚
• 项目类别: Discovery Projects
• 财政年份: 2021
• 资助国家: 澳大利亚
• 起止时间: 2021-06-01 至 2023-12-31
• 项目状态: 已结题
• 来源: https://dataportal.arc.gov.au/RGS/Web/Grants/DP210101504
• 关键词: Probing; role; dynamics; protein; modulation

Life relies upon the fundamental ability to convert external stimuli into an appropriate biological response. Such stimuli are transmitted by cell surface proteins (receptors), which convert this stimulus into an intracellular signal. The largest group of cell surface receptors is the G protein-coupled receptor (GPCR) family. Despite advances in GPCR structure determination, many questions regarding the structural basis of GPCR function and signalling remain unanswered. The primary outcome of this project is to provide mechanistic insight into the dynamics of GPCR ligand recognition and activation to advance our understanding of GPCR signal transduction, a fundamental biological process for all living organisms.

生命依赖于将外部刺激转化为适当的生物反应的基本能力。此类刺激由细胞表面蛋白（受体）传递，细胞表面蛋白将这种刺激转化为细胞内信号。最大的细胞表面受体群是 G 蛋白偶联受体 (GPCR) 家族。尽管 GPCR 结构测定取得了进展，但有关 GPCR 功能和信号传导的结构基础的许多问题仍未得到解答。该项目的主要成果是提供对 GPCR 配体识别和激活动力学的机制见解，以增进我们对 GPCR 信号转导（所有生物体的基本生物过程）的理解。