Subtype selectivity and functional bias of receptor positive allosteric modulators for understanding models of pulmonary disease

受体正变构调节剂的亚型选择性和功能偏倚用于理解肺部疾病模型

• 批准号: LP120200778
• 负责人: Prof Patrick Sexton
• 金额: $ 41.48万
• 依托单位: Monash University
• 依托单位国家: 澳大利亚
• 项目类别: Linkage Projects
• 财政年份: 2013
• 资助国家: 澳大利亚
• 起止时间: 2013-02-17 至 2015-12-31
• 项目状态: 已结题
• 来源: https://dataportal.arc.gov.au/RGS/Web/Grants/LP120200778
• 关键词: Subtype; selectivity; functional; bias; receptor

G-protein-coupled receptors (GPCRs) are an important superfamily of proteins that are involved in a myriad of physiological processes and a wide range of serious illnesses. This project seeks to gain a more detailed understanding of new mechanisms of GPCR modulation and function that will be of direct relevance to drug discovery.

g蛋白偶联受体（gpcr）是一个重要的蛋白质超家族，参与了无数的生理过程和广泛的严重疾病。该项目旨在更详细地了解GPCR调节和功能的新机制，这将与药物发现直接相关。