Training in Translational Research of Lung, Head and Neck Cancer

描述（由申请人提供）：肺癌和头颈癌的不良预后在过去三十年中没有改善;两者在很大程度上都与烟草有关。科罗拉多大学癌症中心（UCCC）有一个肺癌、头颈癌（LHN）项目，其总体目标是将科学研究发现转化为预防和治疗干预措施，以降低LHN癌症的发病率和死亡率。该申请提出了全项目范围的培训，这将最好地利用资源和专业知识来培训致力于LHN研究的下一代基础科学家和医生科学家。根据NCI的博士后/博士前的比例要求，我们建议每个奖励年度任命3名新的博士后和1名新的博士前学生。共有29名培训教师是根据他们的科学/临床专业知识和指导的跟踪记录从UCCC的活跃成员中选出的，以实现翻译LHN研究的培训。这些教师来自基础科学和临床部门。除了实验室培训外，我们还为所有学员设计了强制性教学课程，为非MD学员设计了临床课程，以提高学员的科学背景和我们计划的翻译方面。我们的具体目标是，该计划的学员将获得在基础和翻译LHN研究的生产性学术生涯的专业技能。我们将根据学员的学术记录和对LHN研究的承诺，从外部和内部培训人才库中大力选拔学员。

DESCRIPTION (provided by applicant): The poor prognosis of lung cancer and head and neck cancer has not improved in the past three decades; both are largely tobacco associated. The University of Colorado Cancer Center (UCCC) has a Lung, Head and Neck cancer (LHN) Program with the overall goal of translating scientific research discoveries into preventive and therapeutic interventions to decrease the incidence and mortality of LHN cancers. This application proposes program-wide training, which will best utilize resources and expertise to train the next-generation of basic- and physician-scientists dedicated to LHN research. Based on the NCI's postdoctoral/predoctoral ratio requirement of, we propose to appoint 3 new postdocs and 1 new predoctoral student per award year. The total of 29 training faculty members are selected from active members of UCCC based on their scientific/clinical expertise and track records of mentorship to achieve training of translational LHN research. These faculty members are from both basic science and clinical departments. In addition to laboratory training, we have designed mandatory didactic coursework for all trainees and clinical coursework for non-MD trainees to enhance the trainee's scientific background and the translational aspect of our program. Our specific goal is that the program's trainees will acquire the professional skills for productive academic careers in basic and translational LHN research. We will vigorously select trainees from external and internal trainee pools based on their academic records and commitments to LHN research.