Objectively Measured Physical Activity and Mortality in Women

客观测量女性体力活动和死亡率

• 批准号: 8403792
• 负责人: I-Min Lee
• 金额: $ 20.47万
• 依托单位: BRIGHAM AND WOMEN'S HOSPITAL
• 依托单位国家: 美国
• 财政年份: 2011
• 资助国家: 美国
• 起止时间: 2011-01-12 至 2014-12-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8403792
• 关键词: Acceleration; Address; Adult; American; Applications Grants; Behavior; Biochemical Genetics; Biological Markers; Blood specimen; Cardiovascular Diseases; Cause of Death; Cessation of life; Chronic Disease; Clinical; Data; Devices; Dose; Energy Metabolism; Epidemiologic Studies; Exercise; Federal Government; Frequencies; Funding; Future; Guidelines; Health; Health Benefit; High Prevalence; Hypertension; Individual; Knowledge; Label; Light; Measurement; Measures; Medical History; Morbidity - disease rate; Movement; Non-Insulin-Dependent Diabetes Mellitus; Observational Study; Patient Self-Report; Persons; Physical activity; Physical assessment; Plasma; Primary Prevention; Public Health; Questionnaires; Randomized Controlled Trials; Recommendation; Recruitment Activity; Reporting; Resources; Risk; Risk Factors; Risk Reduction; Smoker; Smoking; Supervision; Surveys; Time; Water; Woman; Women' s Health; base; cancer type; cardiovascular risk factor; cost; follow-up; gene interaction; genome wide association study; heart disease risk; indexing; meetings; men; mortality; national surveillance; physical conditioning; premature; public health relevance; randomized trial; response; sedentary

DESCRIPTION (provided by applicant): This proposal seeks funding to measure physical activity objectively using the Actigraph GT3X accelerometer, a device that can accurately measure movement accelerations in three planes, among 21,249 women in the Women's Health Study and to follow them over 4 years for mortality. Already available are data from annual questionnaires over 15 years on risk factors (including self-reported physical activity every 2-3 years) and medical history in women, as well as plasma biomarker and whole genome scan data from blood samples collected at baseline. Morbidity follow-up is well over 90% and mortality follow-up is virtually 100%. In 2008, the federal government released its first-ever Physical Activity Guidelines for Americans, recommending the types and amounts of physical activity believed to offer substantial health benefits. The basis for these guidelines comes almost exclusively from observational epidemiologic studies of clinical endpoints, with physical activity assessed by self-report. Supporting such studies are data from randomized controlled trials of supervised exercise and cardiovascular risk factors, providing plausible biologic underpinnings for the lower risks of chronic diseases with physical activity. However, national surveys using self-reported physical activity show 47-50% of American adults meet physical activity recommendations, but national surveys measuring physical activity objectively using accelerometers indicate that <5% do so. Additionally, recent data suggest that sedentary behavior (e.g., time sitting) may be an independent risk factor, separate from physical activity, for chronic diseases. Sedentary behavior is imprecisely measured using self- reports, but can be accurately determined using accelerometers. Thus, the present proposal seeks to clarify the relations between physical activity, as well as sedentary behavior, and mortality by objectively measuring physical activity and sedentary behavior. Women will be asked to wear the Actigraph accelerometer for 1 week. Women will be recruited on a rolling basis over 2 years. Data from the accelerometers will classify women according to the time spent in light, moderate, and vigorous intensity physical activity (or combinations thereof), and sedentary behavior. At the end of the study, we will use the National Death Index to ascertain decedents. We will have sufficient statistical power to determine associations between physical activity, or sedentary behavior, and all-cause mortality. We also will be able to compare self-reported and accelerometer-measured physical activity, providing useful data on measurement error correction for other epidemiologic studies which may not have the resources to objectively measure physical activity. Finally, this study will be of tremendous advantage for future grant applications to cost- efficiently address the associations of objectively measured physical activity with other clinical endpoints which will accumulate in sufficient numbers over time, such as incident cardiovascular disease, cancer, and type 2 diabetes, all major causes of morbidity and mortality, as well as to examine physical activity-gene interactions. 1

描述（由申请人提供）：该提案寻求资金，以使用Actigraph GT 3X加速度计客观地测量身体活动，这是一种可以准确测量三个平面运动加速度的设备，在妇女健康研究中的21，249名妇女中，并跟踪她们4年以上的死亡率。目前已经有15年来关于风险因素（包括每2-3年自我报告的身体活动）和女性病史的年度问卷调查数据，以及基线时收集的血液样本的血浆生物标志物和全基因组扫描数据。死亡率随访率超过90%，死亡率随访率几乎为100%。 2008年，联邦政府发布了有史以来第一份《美国人身体活动指南》，推荐了被认为对健康有益的身体活动的类型和数量。这些指南的基础几乎完全来自临床终点的观察性流行病学研究，通过自我报告评估体力活动。支持这些研究的是来自监督运动和心血管危险因素的随机对照试验的数据，为体力活动降低慢性疾病风险提供了合理的生物学基础。然而，使用自我报告的身体活动的全国性调查显示，47-50%的美国成年人符合身体活动建议，但使用加速度计客观测量身体活动的全国性调查表明，<5%的人这样做。此外，最近的数据表明，久坐行为（例如，久坐）可能是一个独立的风险因素，独立于身体活动，慢性疾病。使用自我报告来测量久坐行为是不精确的，但是可以使用加速度计来精确地确定。 因此，本提案旨在通过客观地测量身体活动和久坐行为来澄清身体活动以及久坐行为与死亡率之间的关系。女性将被要求佩戴Activograph加速计1周。妇女将在两年内滚动征聘。来自加速度计的数据将根据女性在轻度、中度和剧烈强度的体力活动（或其组合）以及久坐行为中所花费的时间对她们进行分类。在研究结束时，我们将使用国家死亡指数来确定死者。我们将有足够的统计能力来确定体力活动或久坐行为与全因死亡率之间的关联。我们还将能够比较自我报告和加速度计测量的身体活动，为其他可能没有资源客观测量身体活动的流行病学研究提供测量误差校正的有用数据。最后，这项研究将具有巨大的优势，为未来的拨款申请，以成本效益的方式解决客观测量的身体活动与其他临床终点的关联，这些临床终点将随着时间的推移而积累足够的数量，如突发心血管疾病，癌症和2型糖尿病，所有主要的发病率和死亡率，以及检查身体活动-基因相互作用。1