Developmental Activities

在达特茅斯CCNE（DCCNE）内产生的发展活动将被设计为（1）促进癌症纳米技术的研究;（2）促进癌症中心的肿瘤学家与塞耶工程学院的工程师和材料科学家的互动;（三）促进DCCNE研究人员提出研究建议，并就参与机构的综合能力所能实现的项目进行合作，CCNE联盟;（4）联盟挑战项目。达特茅斯已经在癌症纳米技术方面培养了五年多的试点项目，最近一次是在2009年秋季资助了四个新项目，行政核心的工作人员有多年成功实施这种机制的经验。我们期待与联盟成员在与达特茅斯发起的项目相关的各种纳米技术合作方面进行丰富的双向互动，并为感兴趣的DCCNE教师提供加入联盟研究的机会。我们预计，来自其他中心的见解在纳米技术平台的合成，并在生物相容性问题相关的纳米结构在动物中的使用将提供新的机会DCCNE。另外。在抗体和靶向配体与纳米结构结合方面的联盟经验可以为DCCNE提出的工作提供重要的研究协同作用。 该达特茅斯CCNE也处于有利地位，与国家资源，如NCI纳米技术表征实验室和caNanoLab进行富有成效的合作。DCCNE认识到有必要在推进癌症纳米技术领域的倡议上进行国家合作，该中心期待着为参与联盟倡议以实现这一目标做出贡献。DCCNE主任将作为达特茅斯CCNE的代表在联盟协调和治理委员会任职，并为该论坛产生的同行倡议做出贡献。他的参与将代表一个门户，使更多的DCCNE教师可以被确定为考虑整个联盟共同关心的其他问题的关键资源，包括临床翻译和工业商业化等领域。

Developmental activities arising within the Dartmouth CCNE (DCCNE) will be designed to (1) foster research in cancer nanotechnology; (2) facilitate interactions of oncologists at the Cancer Center with engineers and materials scientists at Thayer School of Engineering; (3) facilitate efforts by DCCNE investigators to propose studies and collaborate on projects that are made feasible by the composite capabilities of the institutions participating in The CCNE Alliance; and (4) Alliance Challenge Projects. Dartmouth has fostered pilot projects in cancer nanotechnology for more than five years, most recently funding four new projects in Fall 2009, and the staff members ofthe Administrative Core have many years experience implementing such mechanisms successfully. We anticipate rich bidirectional interactions with The Alliance members in collaborating on diverse nanotechnologies relevant to Dartmouth-initiated projects and the opportunity for interested DCCNE faculty to join in Alliance studies. We anticipate that insights from other centers in the synthesis of nanotechnology platforms, and in biocompatibility issues related to the use of nanostructures in animals will provide new opportunities for the DCCNE. In addition. Alliance-based experience in the conjugation of antibodies and targeting ligands to nanostructures can provide significant research synergies for work proposed by the DCCNE. The Dartmouth CCNE is also well positioned to collaborate productively with national resources such as the NCI Nanotechnology Characterization Laboratory and caNanoLab. The DCCNE recognizes the need for national collaborations on initiatives to advance the field of cancer nanotechnology, and the Center looks forward to contributing effort toward participating in Alliance initiatives to achieve this aim. The DCCNE Director will serve on the Alliance Coordinating and Governance Committee as representative of the Dartmouth CCNE and as a contributor to peer initiatives arising from that forum. His participation will represent the portal whereby additional DCCNE faculty can be identified as key resources for considerations on other issues of common interest across the Alliance, including such areas as clinical translation and industrial commercialization.