Developmental Activities

达特茅斯CCNE(DCCNE)的开发活动将旨在：(1)促进癌症纳米技术的研究；(2)促进癌症中心肿瘤学家与塞耶工程学院的工程师和材料科学家的互动；(3)促进DCCNE研究人员提出研究建议，并就参与CCNE联盟的机构的综合能力使之可行的项目进行合作；以及(4)联盟挑战项目。五年多来，达特茅斯一直在推动癌症纳米技术的试点项目，最近一次是在2009年秋季资助了四个新项目，行政核心的工作人员拥有成功实施此类机制的多年经验。我们期待着与联盟成员在与达特茅斯发起的项目相关的各种纳米技术方面进行丰富的双向互动，并有机会让感兴趣的DCCNE教职员工加入联盟的研究。我们预计，来自其他中心在纳米技术平台合成方面的见解，以及与在动物中使用纳米结构相关的生物兼容性问题，将为DCCNE提供新的机会。此外。在抗体偶联和将配体定向到纳米结构方面的联盟经验可以为DCCNE提出的工作提供重要的研究协同效应。 达特茅斯CCNE还处于有利地位，可以与NCI纳米技术表征实验室和caNanoLab等国家资源进行富有成效的合作。DCCNE认识到需要在推进癌症纳米技术领域的倡议方面进行国家合作，该中心期待着为参与联盟的倡议做出贡献，以实现这一目标。DCCNE主任将作为达特茅斯CCNE的代表在联盟协调和治理委员会任职，并作为该论坛产生的同行倡议的贡献者。他的参与将代表着门户网站，通过该门户网站，可以确定更多的DCCNE教师作为关键资源，用于考虑整个联盟共同感兴趣的其他问题，包括临床翻译和工业商业化等领域。

Developmental activities arising within the Dartmouth CCNE (DCCNE) will be designed to (1) foster research in cancer nanotechnology; (2) facilitate interactions of oncologists at the Cancer Center with engineers and materials scientists at Thayer School of Engineering; (3) facilitate efforts by DCCNE investigators to propose studies and collaborate on projects that are made feasible by the composite capabilities of the institutions participating in The CCNE Alliance; and (4) Alliance Challenge Projects. Dartmouth has fostered pilot projects in cancer nanotechnology for more than five years, most recently funding four new projects in Fall 2009, and the staff members ofthe Administrative Core have many years experience implementing such mechanisms successfully. We anticipate rich bidirectional interactions with The Alliance members in collaborating on diverse nanotechnologies relevant to Dartmouth-initiated projects and the opportunity for interested DCCNE faculty to join in Alliance studies. We anticipate that insights from other centers in the synthesis of nanotechnology platforms, and in biocompatibility issues related to the use of nanostructures in animals will provide new opportunities for the DCCNE. In addition. Alliance-based experience in the conjugation of antibodies and targeting ligands to nanostructures can provide significant research synergies for work proposed by the DCCNE. The Dartmouth CCNE is also well positioned to collaborate productively with national resources such as the NCI Nanotechnology Characterization Laboratory and caNanoLab. The DCCNE recognizes the need for national collaborations on initiatives to advance the field of cancer nanotechnology, and the Center looks forward to contributing effort toward participating in Alliance initiatives to achieve this aim. The DCCNE Director will serve on the Alliance Coordinating and Governance Committee as representative of the Dartmouth CCNE and as a contributor to peer initiatives arising from that forum. His participation will represent the portal whereby additional DCCNE faculty can be identified as key resources for considerations on other issues of common interest across the Alliance, including such areas as clinical translation and industrial commercialization.