Understanding Ethnic Differences in Cancer: The Multiethnic Cohort Study

了解癌症的种族差异：多种族队列研究

• 批准号: 8535137
• 负责人: BRIAN E HENDERSON
• 金额: $ 362.25万
• 依托单位: UNIVERSITY OF HAWAII AT MANOA
• 依托单位国家: 美国
• 财政年份: 2012
• 资助国家: 美国
• 起止时间: 2012-09-01 至 2017-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8535137
• 关键词: African American; Area; Biological Markers; Blood; Breast; California; Cancer Etiology; Caring; Caucasians; Caucasoid Race; Chronic Disease; Cohort Studies; Collection; Colorectal; Colorectal Cancer; Communities; Complex; Computers; Cultural Diversity; DNA; Data; Data Analyses; Databases; Diet; Disease; Early Diagnosis; Early treatment; Environmental Risk Factor; Ethnic group; Exposure to; Folate; Food Supplements; Genetic; Genetic Markers; Genetic Risk; Genotype; Geographic Locations; Goals; Grant; Hawaii; Hawaiian population; Head; Health; Hormones; Hour; Individual; Instruction; Intake; Japanese American; Joints; Latino; Leadership; Lymphocyte; Mails; Maintenance; Malignant Neoplasms; Malignant neoplasm of lung; Malignant neoplasm of ovary; Measures; Medical; Methodology; Minority; Monitor; Normal tissue morphology; Nutrient; Nutritional; Obesity; Outcome; Paper; Participant; Pattern; Population; Postdoctoral Fellow; Prevention; Prostate; Publishing; Questionnaires; Research; Research Infrastructure; Research Personnel; Research Project Grants; Resources; Risk; Risk Factors; Saliva; Selenium; Specimen; Students; System; Training; Underserved Population; Update; Urine; Vitamin E; Woman; Women' s Health; Work; biobank; cancer risk; cancer site; cohort; data management; data sharing; design; disorder risk; ethnic difference; follow-up; genetic epidemiology; genetic variant; genome wide association study; improved; insight; malignant breast neoplasm; men; nutrition; nutritional epidemiology; programs; prospective; racial and ethnic; racial and ethnic disparities; repository; tumor; willingness

DESCRIPTION (provided by applicant): This application seeks support for the infrastructure of the Multiethnic Cohort (MEC) Study, which was established in Hawaii and southern California between 1993 and 1996 to study risk factors for cancer and other chronic diseases. The study was designed to take advantage of the ethnic and cultural diversity of the two geographic areas, as well as the expertise of the senior investigators in nutrition, ethnic/racial studies, and, subsequently, genetics. It is the most ethnically heterogeneous cancer cohort in existence. At baseline, the cohort included information on 215,000 men and women, comprised, by design, almost entirely of five ethnic/racial populations: Caucasians, Japanese Americans, Native Hawaiians, African Americans, and Latinos. The resource was later expanded to include a prospective bio repository of blood and urine specimens from ~ 70,000 of the participants. Leadership of the MEC entails a highly interactive, team approach; and the investigators have amply demonstrated their willingness to share data and participate actively in consortium projects. This application describes our aims over the next five years for maintaining and enhancing the infrastructure of the MEC, as well as plans for methodological research in the areas of genetic and nutritional epidemiology that utilize the resources of the cohort. Research accomplishments to date include significant contributions to understanding both genetic and environmental risk factors for cancer, particularly related to breast, prostate, colorectal and lun cancers. Nearly 250 papers describing these findings have been published. In addition, primarily over the last 20 years, more than 50 research grants have been built around the MEC, and more than 50 students and postdoctoral fellows have been trained on the study. This new grant will make possible the continuation of a well-integrated program of research aimed at evaluating environmental factors and genetic variants as risk factors for cancer and other common chronic diseases.

描述（由申请人提供）：本申请寻求对多种族队列（MEC）研究基础设施的支持，该研究于1993年至1996年期间在夏威夷和南加州建立，以研究癌症和其他慢性疾病的风险因素。该研究旨在利用两个地理区域的种族和文化多样性，以及营养，种族/种族研究以及遗传学方面的高级研究人员的专业知识。它是现存的种族最异质的癌症队列。在基线时，该队列包括215，000名男性和女性的信息，根据设计，几乎完全由五个种族/种族人群组成：高加索人，日裔美国人，夏威夷原住民，非洲裔美国人和拉丁美洲人。该资源后来扩大到包括来自约70，000名参与者的血液和尿液标本的前瞻性生物储存库。MEC的领导需要高度互动的团队方法;调查人员充分展示了他们分享数据和积极参与联合项目的意愿。本申请描述了我们在未来五年内维护和加强MEC基础设施的目标，以及利用队列资源在遗传和营养流行病学领域进行方法学研究的计划。迄今为止的研究成果包括对理解癌症的遗传和环境风险因素做出了重大贡献，特别是与乳腺癌，前列腺癌，结肠直肠癌和肺癌有关的癌症。已经发表了近250篇描述这些发现的论文。此外，主要是在过去的20年里，围绕MEC建立了50多项研究赠款，并对50多名学生和博士后进行了研究培训。这项新的拨款将使一项旨在评估环境因素和遗传变异作为癌症和其他常见慢性病风险因素的综合研究计划得以继续。