New management of vocal scar with antibody/ICG guided laser

使用抗体/ICG 引导激光治疗声带疤痕的新方法

• 批准号: 8509129
• 负责人: ZHI WANG
• 金额: $ 28.65万
• 依托单位: BOSTON UNIVERSITY MEDICAL CAMPUS
• 依托单位国家: 美国
• 财政年份: 2013
• 资助国家: 美国
• 起止时间: 2013-03-25 至 2015-02-28
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8509129
• 关键词: Abbreviations; Antibodies; Boston; Cells; Cicatrix; Clinic; Clinical; Collagen; Collagen Fibril; Development; Dyes; Excision; Fibroblasts; Healed; Histology; Immunoconjugates; Indocyanine Green; Injection of therapeutic agent; Intralesional Injections; Knowledge; Laryngeal Diseases; Laser Surgery; Lasers; Liver Fibrosis; Methods; Microscopic; Modeling; Nodule; Operative Surgical Procedures; Patients; Pharmaceutical Preparations; Physicians; Physiologic pulse; Procedures; Rattus; Reporting; Safety; Skin; Surface; Techniques; Testing; Therapeutic; Tissues; Trauma; Treatment Effectiveness; Treatment Efficacy; Voice; Voice Quality; antibody conjugate; base; density; functional outcomes; healing; minimally invasive; novel strategies; photolysis; public health relevance; research study; success; vocal cord

DESCRIPTION (provided by applicant): Vocal scar is one of the most common causes of poor voice and airway function. It presents a real challenge for physicians. Current treatment options include topical or intralesional injections, surgical resection or grafting, and other managements. But these procedures usually are invasive or have no selectivity to the target and frequently yield disappointing results. Thus new approach is highly desirable. Immunoconjugate-guided laser treatment is a minimally-invasive management that has been used successfully for skin scars and other applications in the clinic to seek improvement in treatment efficacy and safety. Unfortunately, there is little wor done to explore its utility for management of scaring in vocal folds. In this study, our hypothesis is that a 810 nm pulsed diode laser, guided by a conjugate of antibody and ICG, would be effective and safe for early management of the vocal scar in a rat model. To our best of knowledge, this will be the first study to do so. To validate this hypothesis, we will have two specific aims: (1) to optimize our treatment parameters in scar on skin; and then (2) to determine the treatment effectiveness and safety directly in the vocal scar by objective assessments of histology and vocal functions. We expect this new treatment, if successful in this study, will provide a promising management for this problem, and it would be safe and convenient as an office-based procedure.

描述（由申请人提供）： 声带瘢痕是造成嗓音和气道功能不良的最常见原因之一。这对医生来说是一个真实的挑战。目前的治疗选择包括局部或病灶内注射，手术切除或移植，以及其他管理。但这些手术通常是侵入性的，或者对靶点没有选择性，结果往往令人失望。因此，新的方法是非常可取的。免疫结合物引导的激光治疗是一种微创治疗，已成功用于皮肤疤痕和临床上的其他应用，以提高治疗效果和安全性。不幸的是，很少有人做，以探讨其效用的管理声带瘢痕。在这项研究中，我们的假设 由抗体和ICG的缀合物引导的810 nm脉冲二极管激光对于大鼠模型中的声带瘢痕的早期管理是有效和安全的。据我们所知，这将是第一项这样做的研究。为了验证这一假设，我们将有两个具体目标：（1）优化我们在皮肤瘢痕中的治疗参数;然后（2）通过客观评估组织学和发声功能直接确定声带瘢痕的治疗有效性和安全性。我们希望这种新的治疗方法，如果在这项研究中成功，将为这个问题提供一个有前途的管理，它将是安全和方便的办公室为基础的程序。