New management of vocal scar with antibody/ICG guided laser

描述(由申请人提供)： 声带疤痕是导致嗓音和呼吸道功能不良的最常见原因之一。这对医生来说是一个真正的挑战。目前的治疗选择包括局部或病灶内注射，手术切除或移植，以及其他治疗方法。但这些程序通常是侵入性的，或者对靶点没有选择性，经常产生令人失望的结果。因此，新的方法是非常可取的。免疫结合物引导激光治疗是一种微创治疗方法，已成功应用于皮肤瘢痕和其他临床应用，以寻求治疗效果和安全性的提高。不幸的是，几乎没有人探索它在治疗声带惊吓方面的作用。在这项研究中，我们的假设 在抗体和ICG结合的引导下，810 nm脉冲半导体激光对大鼠模型声带瘢痕的早期治疗是安全有效的。据我们所知，这将是第一个这样做的研究。为了验证这一假设，我们将有两个具体的目标：(1)优化我们对皮肤瘢痕的治疗参数；然后(2)通过对组织学和发声功能的客观评估，直接确定治疗声带瘢痕的有效性和安全性。我们希望这种新的治疗方法，如果在这项研究中成功，将为这一问题提供一种有希望的治疗方法，作为一种基于办公室的手术将是安全和方便的。

DESCRIPTION (provided by applicant): Vocal scar is one of the most common causes of poor voice and airway function. It presents a real challenge for physicians. Current treatment options include topical or intralesional injections, surgical resection or grafting, and other managements. But these procedures usually are invasive or have no selectivity to the target and frequently yield disappointing results. Thus new approach is highly desirable. Immunoconjugate-guided laser treatment is a minimally-invasive management that has been used successfully for skin scars and other applications in the clinic to seek improvement in treatment efficacy and safety. Unfortunately, there is little wor done to explore its utility for management of scaring in vocal folds. In this study, our hypothesis is that a 810 nm pulsed diode laser, guided by a conjugate of antibody and ICG, would be effective and safe for early management of the vocal scar in a rat model. To our best of knowledge, this will be the first study to do so. To validate this hypothesis, we will have two specific aims: (1) to optimize our treatment parameters in scar on skin; and then (2) to determine the treatment effectiveness and safety directly in the vocal scar by objective assessments of histology and vocal functions. We expect this new treatment, if successful in this study, will provide a promising management for this problem, and it would be safe and convenient as an office-based procedure.