Imaging Evaluation of Cancer Chemoprevention

癌症化学预防的影像学评价

• 批准号: 7028057
• 负责人: ZHI WANG
• 金额: $ 15.41万
• 依托单位: BOSTON UNIVERSITY MEDICAL CAMPUS
• 依托单位国家: 美国
• 财政年份: 2006
• 资助国家: 美国
• 起止时间: 2006-04-01 至 2008-01-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7028057
• 关键词: bioimaging /biomedical imaging; biopsy; carcinogenesis; cheek pouch technique; chemoprevention; diagnosis quality /standard; disease /disorder model; hamsters; histopathology; mouth neoplasms; neoplasm /cancer diagnosis; neoplasm /cancer imaging; neoplasm /cancer invasiveness; nonhuman therapy evaluation; noninvasive diagnosis; preneoplastic state; retinoids; technology /technique development

DESCRIPTION (provided by applicant): Cancer chemoprevention is a promising approach to fighting cancers. However, current methods to evaluate treatment efficacy, in order to identify new and promising chemopreventive agents/regimes, largely depend on invasive tissue biopsy or later endpoints (e.g., reduction of tumor incidence or size). Current methods entail significant distress to patients or require a long term clinical trial. It is particularly difficult to use these approaches for early, timely, and frequent evaluation during the chemoprevention treatment period. Our recent studies indicate that a newly-developed optic imaging technology has great potential for real-time, noninvasive cancer detection by observing subtle alterations in the nuclear morphology of epithelial cells. This technology has never been applied to cancer chemoprevention. In this proposed study, our hypothesis is that the treatment efficacy and response to oral cancer chemoprevention can be monitored and predicted with nuclear imaging prior to invasive tissue biopsy or tumor incidence outcome obtained at the end of the i treatment. We will test our hypothesis in the cheek pouches of a hamster model by establishing tissue "imaging grading" and then predicting the efficacy of retinoid acid chemoprevention. Our specific aims are (1) to characterize and refine this imaging technique by comparing the imaging data with subsequent tissue biopsy results from different developmental stages of oral premalignant lesions to establish nuclear imaging grading; and (2) to determine the capacity of this imaging for noninvasive evaluation and predication of treatment efficacy before the end of a 7-week course of oral cancer chemoprevention with retinoic acid. This is the first study to establish such epithelial imaging classification and use the imaging findings for monitoring and predication of cancer chemoprevention. This proposed study, if successful, will provide an ideal objective tool for treatment monitoring during cancer chemoprevention that will have significant impact on future development of new and improved cancer chemoprevention agents and strategies.

描述（由申请人提供）：癌症化学预防是一种很有前途的抗癌方法。然而，为了鉴定新的和有希望的化学预防剂/方案，目前评估治疗功效的方法在很大程度上取决于侵入性组织活检或后期终点（例如，肿瘤发生率或大小的降低）。目前的方法会给患者带来严重的痛苦，或者需要长期的临床试验。在化学预防治疗期间，使用这些方法进行早期，及时和频繁的评估特别困难。我们最近的研究表明，一种新开发的光学成像技术具有很大的潜力，通过观察上皮细胞核形态的细微变化，进行实时，非侵入性的癌症检测。这项技术从未应用于癌症化学预防。在这项拟议的研究中，我们的假设是，在侵入性组织活检或治疗结束时获得的肿瘤发病率结果之前，可以用核成像监测和预测口腔癌化学预防的治疗疗效和反应。我们将通过建立组织“成像分级”，然后预测维甲酸化学预防的功效，在仓鼠模型的颊囊中检验我们的假设。我们的具体目标是：（1）通过将成像数据与口腔癌前病变不同发展阶段的后续组织活检结果进行比较，以建立核成像分级，来表征和完善这种成像技术;（2）在维甲酸口腔癌化学预防7周疗程结束前，确定这种成像用于非侵入性评价和预测治疗疗效的能力。这是第一个建立这种上皮成像分类的研究，并使用成像结果来监测和预测癌症的化学预防。这项拟议的研究，如果成功的话，将提供一个理想的客观工具，治疗监测癌症化学预防期间，将有重大影响，未来发展的新的和改进的癌症化学预防剂和策略。