Topical 'photo-chemoprevention' of oral leukoplakia
Topical 'photo-chemoprevention' of oral leukoplakia
批准号:
6502338
负责人:
ZHI WANG
金额:
$4.08万
依托单位国家:
美国
项目类别:
财政年份:
2001
资助国家:
美国
项目状态:
已结题
起止时间:
2001-04-01 至 2003-03-31
关键词:
13 cis retinoate biomaterials cancer prevention carcinogenesis inhibitor cheek pouch technique chemical carcinogenesis chemoprevention chemotherapy combination therapy dimethylbenzanthracene hamsters laser therapy nonhuman therapy evaluation nutrition aspect of cancer nutrition related tag oral leukoplakia topical drug application
中文摘要
描述(由申请人提供):
流行病学研究支持高摄入量与
水果和蔬菜以及患癌症的低风险。这样做的长期目标是
项目是研究水果色素,特别是花青素,是否能防止
人类的癌症。花青素是黄酮类植物中的一类。
化合物,其特征是黄色素核。浆果是
世界上广泛食用的典型水果,有深红色、紫色和蓝色
色泽鲜艳,富含花青素。我们的假设是花青素-
丰富的浆果可能在预防癌症方面发挥重要作用。
关于黄曲霉毒素的抗癌作用的信息很少。
浆果,包括标准化、安全性、生物利用度和生物活性。
这项提议将为更广泛的化学预防研究奠定基础。
浆果的味道。天然花青素有7000多种。蓝蛋白是一种典型的
花青素呈红色,存在于大多数浆果中。黑木莓是一种
黑果天牛属植物的美洲原住民浆果。与其他
浆果中,它含有较多的花青素,约占总花青素的96%。在……里面
这个建议我们将重点放在标准化的化学预防作用上
一种新型的木莓提取物(SECK)及其主要蓝蛋白成分
三维重组正常人上皮细胞培养模型
正常人表皮角质形成细胞(NHEK)和正常人支气管
上皮细胞(NHBE)。这项提议的三个具体目标是:1)安全
SECK在三维NHEK和NHTBE中的评价2)SECK的三维生物利用度
NHEK和NHBE以及3)Seck对苯并(A)芘诱导的三维细胞凋亡的影响
Nhek和NHBe。这项初步研究将为以下方面提供更有价值的信息
未来的体内临床前和临床研究。我们的3-D重组人
正常的上皮细胞培养模型也可能提供一种快速可靠的模型。
用于筛选化学预防植物类药物。
英文摘要
DESCRIPTION (provided by applicant):
Epidemiological studies support the association between the high intake of
fruits and vegetables and the low risk of cancer. The long-term goal of this
project is to investigate if fruit pigment, especially, anthocyanins, prevent
cancer in humans. Anthocyanins are a class of the general flavonoid group of
compounds, which are characterized by the flavylium nucleus. Berries are
typical fruits widely consumed in the world with dark red, purple and blue
colors, and is rich in anthocyanins. It is our hypothesis that anthocyanin-
rich berries may play an important contribution in the cancer prevention.
Little information is available on the cancer chemoprevention properties of
berries, including standardization, safety, bioavailability and bioactivity.
This proposal would support a basis for more extended chemoprevention research
of berries. There are more 7000 natural anthocyanins. Cyanin is a typical
anthocyanin with red color and occurs in most berries. Black chokeberry is a
native American berry of the Aronia melanocarpa species. Compared to other
berries, it contains more cyanins, about 96% of the total anthocyanins. In
this proposal we will focus on the chemopreventive effect of standardized
extract of chokeberry (SECK) and their major cyanin constituents using a novel
3-dimensional reconstituted normal human epithelium culture model, such as
normal human epidermal keratinocytes (NHEK) and normal human bronchial
epithelium (NHBE). Three Specific Aims of this proposal are: 1) Safety
evaluation of SECK in 3-D NHEK and NHTBE; 2) Bioavailability of SECK in 3-d
NHEK and NHBE and 3) Effect of SECK on benzo(a)pyrene-induced apoptosis in 3-D
NHEK and NHBE. This pilot study will provide more valuable information for
future in vivo preclinical and clinical studies. Our 3-D reconstituted human
normal epithelium culture models may also provide a rapid and reliable model
for screening chemopreventive botanicals.
期刊论文(0)
专著(0)
科研奖励(0)
会议论文
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批准号:8509129
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批准号:7262717
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资助金额:$27.63万
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批准号:7679015
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资助金额:$27.27万
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财政年份:2007
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批准号:7487457
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项目类别:
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资助金额:$27.27万
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财政年份:2007
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负责人:ZHI WANG
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依托单位:
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批准号:7229915
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资助金额:$14.99万
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财政年份:2006
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依托单位:
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批准号:7028057
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资助金额:$15.41万
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批准号:7086799
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资助金额:$24.29万
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财政年份:2005
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负责人:ZHI WANG
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依托单位:
Voice-preserving Treatment of Larynegeal Papilloma
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批准号:6916015
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项目类别:
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资助金额:$24.87万
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财政年份:2005
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负责人:ZHI WANG
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依托单位:
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批准号:7140384
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项目类别:
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资助金额:$19.71万
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财政年份:2005
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负责人:ZHI WANG
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依托单位:
Laser Assisted Celecoxib Treatment of Oral Leukoplakia
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批准号:6916929
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项目类别:
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资助金额:$20.19万
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财政年份:2005
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负责人:ZHI WANG
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依托单位:
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批准号:7024999
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项目类别:
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资助金额:$19.71万
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财政年份:2005
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负责人:ZHI WANG
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依托单位:
Laser Atraumatic Treatment of Ectasias on Vocal Cords
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批准号:6965579
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资助金额:$20.19万
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负责人:ZHI WANG
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项目类别:
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资助金额:$8.08万
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财政年份:2004
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负责人:ZHI WANG
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依托单位:
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批准号:6879268
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依托单位:
Topical 'photo-chemoprevention' of oral leukoplakia
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批准号:6334362
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项目类别:
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资助金额:$3.95万
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财政年份:2001
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批准号:6522944
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资助金额:$8.15万
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财政年份:2001
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Topical 'photo-chemoprevention' of oral leukoplakia
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批准号:6583712
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依托单位:
海外基金