9th International Retroviral Nucleocapsid Protein and Assembly Symposium

描述（由申请人提供）：逆转录病毒核衣壳（NC）研讨会（IRNCS）历来关注NC蛋白在HIV-1和其他逆转录病毒中的生物学作用。大约100-120名来自世界各地的研究人员参加了这个两年一次的研讨会，旨在全面了解NC在逆转录病毒发病机制中的作用。NC在以下方面发挥着关键作用：(1)作为伴侣蛋白重塑宿主和病毒核酸；(2)组装并将逆转录病毒基因组RNA靶向到新病毒颗粒上；(3)保护病毒DNA并促进与宿主DNA的整合。其中一些功能是由NC作为前体Gag蛋白的一部分完成的，而其他功能则由成熟的NCp7完成。最近的研究表明，NC在感染后立即发挥作用，并在2012年发现了限制逆转录病毒的作用。因此，NC代表了一个合适的治疗靶点。研讨会将为研究人员（主要研究人员、博士后研究员、学生、研究人员和生物技术代表）提供一个场所，通过关注病毒生命周期中的这一核心因素，在防治艾滋病毒-1/艾滋病以及包括癌症在内的其他逆转录病毒疾病方面取得进展。逆转录病毒国家研讨会长期以来在卓越的研究、促进研究合作、支持青年科学家以及包括传统上在科学领域代表性不足的妇女和其他个人方面有着卓越的记录。今年，我们还将强调NC/Gag在大会中的作用，因为自2000年以来每四年在布拉格举行的逆转录病毒大会将不再举行。因此，我们将会议更名为“第九届国际逆转录病毒NC和大会研讨会”（IRNCAS）。

DESCRIPTION (provided by applicant): The Retroviral Nucleocapsid (NC) Symposium (IRNCS) has historically focused on the biological role of the NC protein in HIV-1 and other retroviruses. Approximately 100-120 researchers worldwide have typically participated at this biennial symposium in an effort to generate a complete picture of the role of NC in retroviral pathogenesis. NC plays critical roles in (1) remodeling host and viral nucleic acids as a chaperone protein, (2) assembly and targeting the retroviral genomic RNA to new virus particles, and (3) protecting viral DNA and facilitating integration into host DNA. Some of these functions are performed by NC as part of the precursor Gag protein, and others are carried out by mature NCp7. More recent work shows that NC plays roles immediately following infection and in 2012, a role in retroviral restriction was discovered. NC therefore represents a suitable target for therapy. The symposium will provide a venue for researchers (principal investigators, postdoctoral fellows, students, research staff and representatives from biotechnology) to make progress in efforts to combat HIV-1/AIDS, as well as other retroviral diseases including cancer, by focusing on this central player in the viral lifecycle. The Retroviral NC Symposium has a long-standing record of research excellence, of promoting research collaborations, supporting young scientists, and including women and other individuals who have been traditionally underrepresented in science. This year, we will also emphasize the role of NC/Gag in assembly as the Retrovirus Assembly Meeting, held every 4 years since 2000 in Prague, will no longer be held. We are therefore renaming the conference as the "9th International Retroviral NC and Assembly Symposium" (IRNCAS).