9th International Retroviral Nucleocapsid Protein and Assembly Symposium

第九届国际逆转录病毒核衣壳蛋白与组装研讨会

• 批准号: 8542099
• 负责人: Karin M Musier-Forsyth
• 金额: $ 0.45万
• 依托单位: OHIO STATE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2013
• 资助国家: 美国
• 起止时间: 2013-04-15 至 2014-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8542099
• 关键词: Acquired Immunodeficiency Syndrome; Amino Acid Motifs; Biological; Biotechnology; Chemicals; Collaborations; Complex; Conserved Sequence; DNA; Development; Dimerization; Discipline; Disease; Ensure; Environment; Exposure to; Female; Fingers; Funding; Gagging; Genome; Genomics; Glycoproteins; HIV-1; Human T-Cell Leukemia Viruses; Human T-lymphotropic virus 1; Indium; Individual; Infection; International; International Cooperation; Life Cycle Stages; Malignant Neoplasms; Modification; Molecular Chaperones; Names; Nucleic Acids; Nucleocapsid; Nucleocapsid Proteins; Nucleoproteins; Oncogenic; Outcome; Pathogenesis; Physical condensation; Play; Postdoctoral Fellow; Principal Investigator; Production; Proteins; Proviruses; RNA; RNA Viruses; Request for Applications; Research; Research Personnel; Research Training; Retroviridae; Reverse Transcription; Role; Science; Scientist; Students; Time; Transcription Initiation; Transfer RNA; Underrepresented Minority; Vaccines; Viral; Virion; Woman; Work; abstracting; combat; drug development; gag Gene Products; meetings; next generation; novel strategies; particle; public health relevance; scaffold; symposium; therapeutic target; viral DNA; viral RNA; young woman

DESCRIPTION (provided by applicant): The Retroviral Nucleocapsid (NC) Symposium (IRNCS) has historically focused on the biological role of the NC protein in HIV-1 and other retroviruses. Approximately 100-120 researchers worldwide have typically participated at this biennial symposium in an effort to generate a complete picture of the role of NC in retroviral pathogenesis. NC plays critical roles in (1) remodeling host and viral nucleic acids as a chaperone protein, (2) assembly and targeting the retroviral genomic RNA to new virus particles, and (3) protecting viral DNA and facilitating integration into host DNA. Some of these functions are performed by NC as part of the precursor Gag protein, and others are carried out by mature NCp7. More recent work shows that NC plays roles immediately following infection and in 2012, a role in retroviral restriction was discovered. NC therefore represents a suitable target for therapy. The symposium will provide a venue for researchers (principal investigators, postdoctoral fellows, students, research staff and representatives from biotechnology) to make progress in efforts to combat HIV-1/AIDS, as well as other retroviral diseases including cancer, by focusing on this central player in the viral lifecycle. The Retroviral NC Symposium has a long-standing record of research excellence, of promoting research collaborations, supporting young scientists, and including women and other individuals who have been traditionally underrepresented in science. This year, we will also emphasize the role of NC/Gag in assembly as the Retrovirus Assembly Meeting, held every 4 years since 2000 in Prague, will no longer be held. We are therefore renaming the conference as the "9th International Retroviral NC and Assembly Symposium" (IRNCAS).

描述（由申请人提供）：逆转录病毒核衣壳（NC）研讨会（IRNCS）历来关注NC蛋白在HIV-1和其他逆转录病毒中的生物学作用。全世界大约有100-120名研究人员参加了这个两年一次的研讨会，以全面了解NC在逆转录病毒发病机制中的作用。NC在以下方面发挥关键作用：（1）将宿主和病毒核酸重塑为伴侣蛋白，（2）将逆转录病毒基因组RNA组装并靶向新的病毒颗粒，以及（3）保护病毒DNA并促进整合到宿主DNA中。这些功能中的一些由NC作为前体Gag蛋白的一部分执行，而其他功能由成熟的NCp 7执行。最近的研究表明，NC在感染后立即发挥作用，并在2012年发现了逆转录病毒限制的作用。因此，NC代表了合适的治疗靶点。专题讨论会将为研究人员（主要研究人员、博士后研究员、学生、研究人员和生物技术代表）提供一个场所，通过重点关注病毒生命周期中的这一核心角色，在防治艾滋病毒1型/艾滋病以及包括癌症在内的其他逆转录病毒疾病方面取得进展。逆转录病毒NC研讨会有着长期的卓越研究记录，促进研究合作，支持年轻科学家，并包括传统上在科学中代表性不足的妇女和其他个人。今年，我们还将强调NC/Gag在组装中的作用，因为自2000年以来每4年在布拉格举行一次的逆转录病毒组装会议将不再举行。因此，我们将会议更名为“第九届国际逆转录病毒NC和组装研讨会”（IRNCAS）。