权益分类	功能权益	普通用户	{{item.name}}会员
{{category.name}}	{{benefitItem.name}}

The Functional Organization of Inhibition in the Olfactory Bulb In Vivo

体内嗅球抑制的功能组织

基本信息

批准号：
8573250
负责人：
Michael Nicholas Economo
金额：
$ 3万
依托单位：
UNIVERSITY OF UTAH
依托单位国家：
美国
项目类别：
财政年份：
2012
资助国家：
美国
起止时间：
2012-07-01 至 2014-01-07
项目状态：
已结题

项目摘要

DESCRIPTION (provided by applicant): In the olfactory bulb, a single synapse separates afferent sensory input and the principal neurons that project to higher cortical areas. Nevertheless, the vast majority of cells and connections in this structure are devoted to two distinct inhibitory circuits: one located superficially in the glomerular layer and one involving granule cells in infraglomerular layers. Soon after they were initially described, it was suggested that these inhibitory circuits might provide center-surround inhibition in an analogous fashion to other primary sensory areas. Nevertheless, the manner in which these circuits are activated by olfactory stimuli in vivo has yet to be demonstrated, and their importance in shaping olfactory bulb output remains controversial. In this proposal, the spread of inhibition laterally from the sites of olfactory receptor neuron input through the glomerular layer will be directly visualized t determine how lateral inhibition at this level might contribute to olfactory information processing In addition, the postsynaptic effect of inhibition arising from both lateral circuits will be assesed in identified olfactory bulb output neurons. These experiments will provide crucial insights into the role of lateral inhibitory circuits in vivo, and, by determining the differential effects of thse circuits on the excitability of different classes of output neurons, a better understanding of parallel pathways projecting to higher brain structures.

描述(申请人提供)：在嗅球中，一个单一的突触将传入的感觉输入和投射到高级皮质区域的主神经元分开。然而，该结构中的绝大多数细胞和连接都致力于两个不同的抑制回路：一个位于肾小球表层，另一个涉及肾小球下层的颗粒细胞。在它们最初被描述后不久，有人建议这些抑制回路可能以类似于其他主要感觉区域的方式提供中心-周围抑制。然而，这些回路在体内被嗅觉刺激激活的方式还没有得到证实，它们在形成嗅球输出方面的重要性仍然存在争议。在这个方案中，通过肾小球层输入的嗅觉感受器神经元部位的抑制的横向传播将被直接可视化，以确定该水平的侧抑制如何有助于嗅觉信息处理。此外，将在已识别的嗅球输出神经元中评估来自两个侧回路的抑制的突触后效应。这些实验将为体内侧抑制回路的作用提供重要的见解，并通过确定这些回路对不同类别输出神经元的兴奋性的不同影响，更好地理解投射到高级大脑结构的平行通路。