Functional connectivity substrates of social and non-social deficits in ASD
自闭症谱系障碍(ASD)社会和非社会缺陷的功能连接基础
基本信息
- 批准号:8577455
- 负责人:
- 金额:$ 71.96万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2013
- 资助国家:美国
- 起止时间:2013-09-01 至 2018-05-31
- 项目状态:已结题
- 来源:
- 关键词:AccountingAddressAgeAuditoryAuditory PerceptionAutistic DisorderBehaviorBehavioralBiological MarkersBrain DiseasesChildCommunicationCouplingDataDevelopmentDiagnosisDiseaseEarly DiagnosisEvaluationExhibitsFrequenciesFunctional disorderFutureGoalsGraphIndividualLinkMeasuresModelingNatureParticipantPhasePhenotypeProcessResearchResolutionSeveritiesStagingStimulusSymptomsTestingTractionWorkanalytical toolautism spectrum disorderbaseexecutive functionface perceptionimprovedinnovationneurophysiologynovelnovel strategiespublic health relevancerelating to nervous systemrestrictive repetitive behaviorsocialsocial communicationspeech processingtheoriestooltreatment response
项目摘要
DESCRIPTION (provided by applicant): Over the past decade, the hypothesis that autism spectrum disorder (ASD) is a disorder of reduced long-range and increased local functional connectivity has been gaining traction. To date, however, there is no evidence of increased local functional connectivity in ASD. If, furthermore, ASD is indeed a disorder of functional connectivity, then similar abnormalities ought to manifest in both the social communication (core/defining) and the non-social communication (non-core/non-defining) domains of deficits. Whether this is the case, however, has never been systematically tested in one group of participants. The objectives of the current proposal are to determine the nature of local and long-range functional connectivity abnormalities in ASD, the relationship between them, whether they are manifested similarly in both the core social and non-core non-social domains of ASD deficits, and their correlations with behavioral and structural measures. Our central hypotheses are that ASD is in fact a disorder of connectivity, and that reduced long-range and reduced, not increased, local functional connectivity are distributed, cortex-wide features of ASD, manifested in all domains of deficits. We further hypothesize that local and long-range functional connectivity are reduced proportionally to one another in ASD. These hypotheses will be tested by investigating local and long-range functional connectivity in the social communication (Aim 1) and non-social (Aim 2) domains of deficits of ASD, and their correlation with the ASD phenotype (Aim 3). The proposed studies will take advantage of MEG's high spatial and temporal resolutions to examine functional connectivity in 45 ASD children, ages 8-12, and 45 matched typically developing children, as they perform tasks that tap into core social communication (face perception and speech processing) and non-core (executive control and auditory processing) domains of ASD deficits. The proposed research is conceptually innovative because our hypothesis challenges the prevailing notion that local functional connectivity is increased in ASD, and further proposes a direct correlation between the reductions in local and long-range functional connectivity. Furthermore, it addresses multiple domains of deficits simultaneously in the same participants. The proposed research is analytically innovative because it uses novel analytical tools to study phase-amplitude cross-frequency coupling (a measure of local functional connectivity) non-invasively in cortical space. The proposed research is significant because (a) it will examine the nature of both local and long-range functional connectivity abnormalities in multiple domains of deficits simultaneously, (b) it will determine whether local and long-range functional connectivity abnormalities are directly correlated in ASD, (c) it will provide a novel approach for non-invasively measuring local functional connectivity in cortical space, (d) it will set the stage for developing novel functiona-connectivity based neurophysiological biomarkers for ASD, which have potential applications for treatment and early diagnosis.
DESCRIPTION (provided by applicant): Over the past decade, the hypothesis that autism spectrum disorder (ASD) is a disorder of reduced long-range and increased local functional connectivity has been gaining traction. To date, however, there is no evidence of increased local functional connectivity in ASD. If, furthermore, ASD is indeed a disorder of functional connectivity, then similar abnormalities ought to manifest in both the social communication (core/defining) and the non-social communication (non-core/non-defining) domains of deficits. Whether this is the case, however, has never been systematically tested in one group of participants. The objectives of the current proposal are to determine the nature of local and long-range functional connectivity abnormalities in ASD, the relationship between them, whether they are manifested similarly in both the core social and non-core non-social domains of ASD deficits, and their correlations with behavioral and structural measures. Our central hypotheses are that ASD is in fact a disorder of connectivity, and that reduced long-range and reduced, not increased, local functional connectivity are distributed, cortex-wide features of ASD, manifested in all domains of deficits. We further hypothesize that local and long-range functional connectivity are reduced proportionally to one another in ASD. These hypotheses will be tested by investigating local and long-range functional connectivity in the social communication (Aim 1) and non-social (Aim 2) domains of deficits of ASD, and their correlation with the ASD phenotype (Aim 3). The proposed studies will take advantage of MEG's high spatial and temporal resolutions to examine functional connectivity in 45 ASD children, ages 8-12, and 45 matched typically developing children, as they perform tasks that tap into core social communication (face perception and speech processing) and non-core (executive control and auditory processing) domains of ASD deficits. The proposed research is conceptually innovative because our hypothesis challenges the prevailing notion that local functional connectivity is increased in ASD, and further proposes a direct correlation between the reductions in local and long-range functional connectivity. Furthermore, it addresses multiple domains of deficits simultaneously in the same participants. The proposed research is analytically innovative because it uses novel analytical tools to study phase-amplitude cross-frequency coupling (a measure of local functional connectivity) non-invasively in cortical space. The proposed research is significant because (a) it will examine the nature of both local and long-range functional connectivity abnormalities in multiple domains of deficits simultaneously, (b) it will determine whether local and long-range functional connectivity abnormalities are directly correlated in ASD, (c) it will provide a novel approach for non-invasively measuring local functional connectivity in cortical space, (d) it will set the stage for developing novel functiona-connectivity based neurophysiological biomarkers for ASD, which have potential applications for treatment and early diagnosis.
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
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Tal Kenet其他文献
Tal Kenet的其他文献
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{{ truncateString('Tal Kenet', 18)}}的其他基金
High Temporal Resolution Study of Resting-State Cerebro-Cerebellar Functional Connectivity in ASD
自闭症谱系障碍 (ASD) 静息态脑-小脑功能连接的高时间分辨率研究
- 批准号:
10380250 - 财政年份:2021
- 资助金额:
$ 71.96万 - 项目类别:
High Temporal Resolution Study of Resting-State Cerebro-Cerebellar Functional Connectivity in ASD
自闭症谱系障碍 (ASD) 静息态脑-小脑功能连接的高时间分辨率研究
- 批准号:
10541222 - 财政年份:2021
- 资助金额:
$ 71.96万 - 项目类别:
Testing the Bottom-Up vs Top-Down Imbalance Hypothesis of ASD
测试 ASD 自下而上与自上而下的不平衡假设
- 批准号:
10431883 - 财政年份:2018
- 资助金额:
$ 71.96万 - 项目类别:
Translating MEG-based biomarkers to EEG-based outcome measures for Autism Spectrum Disorders
将基于 MEG 的生物标志物转化为基于 EEG 的自闭症谱系障碍结果测量
- 批准号:
9762202 - 财政年份:2018
- 资助金额:
$ 71.96万 - 项目类别:
Testing the Bottom-Up vs Top-Down Imbalance Hypothesis of ASD
测试 ASD 自下而上与自上而下的不平衡假设
- 批准号:
10208649 - 财政年份:2018
- 资助金额:
$ 71.96万 - 项目类别:
Functional connectivity substrates of social and non-social deficits in ASD
自闭症谱系障碍(ASD)社会和非社会缺陷的功能连接基础
- 批准号:
8728973 - 财政年份:2013
- 资助金额:
$ 71.96万 - 项目类别:
Functional connectivity substrates of social and non-social deficits in ASD
自闭症谱系障碍(ASD)社会和非社会缺陷的功能连接基础
- 批准号:
9066026 - 财政年份:2013
- 资助金额:
$ 71.96万 - 项目类别:
Functional connectivity substrates of social and non-social deficits in ASD
自闭症谱系障碍(ASD)社会和非社会缺陷的功能连接基础
- 批准号:
9291492 - 财政年份:2013
- 资助金额:
$ 71.96万 - 项目类别:
Coherence and Temporal Dynamics in Auditory Cortex of Children with Autism
自闭症儿童听觉皮层的连贯性和时间动态
- 批准号:
7631322 - 财政年份:2008
- 资助金额:
$ 71.96万 - 项目类别:
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