Understanding the role of Ric-8 in Ga 12/13 signaling
Understanding the role of Ric-8 in Ga 12/13 signaling
批准号:
8568833
负责人:
Stephen Rogers
金额:
$7.6万
依托单位国家:
美国
项目类别:
财政年份:
2013
资助国家:
美国
项目状态:
已结题
起止时间:
2013-08-02 至 2015-07-31
关键词:
BindingBiologicalBiological ModelsBlood VesselsCardiovascular systemCellsCytoplasmic ProteinDevelopmentDrosophila genusEmbryoEmbryonic DevelopmentFamilyG-Protein-Coupled ReceptorsGenesGenomeGoalsGuanine Nucleotide Exchange FactorsHeterotrimeric GTP-Binding ProteinsHomologous GeneHormonesHumanInjuryInterventionKnowledgeLigandsMediatingMembraneModelingMolecularMolecular ChaperonesNeurotransmitter ReceptorOutcomePathway interactionsPharmacologic SubstancePlayProcessProteinsPublic HealthRegulationResearchRoleSignal PathwaySignal TransductionSignaling ProteinStructureSystemTestingTherapeuticTranscriptional RegulationVascular Systemangiogenesisextracellularflygastrulationmembermorphogensnovelprotein protein interactionpublic health relevancereceptortooltumor growthtumorigenesis
中文摘要
描述(由申请人提供):异源三聚体G蛋白是重要的双分子开关,其从神经递质、激素和细胞外形态发生素的多种膜受体传递信号,以激活下游细胞内信号传导途径。G的成员?12/13家族在胚胎发育过程中特别重要,因为它们对循环系统的发育至关重要,并且是胚胎血管生成所需的。该提案的目标是了解Ric-8如何参与G?12/13路径。我们将利用果蝇原肠胚形成通路作为研究Ric-8的模型系统,利用强大的细胞生物学工具和丰富的了解G?12/13信号通路。在本研究中,我们将1)在G?12/13信号传导;和2)鉴定调节果蝇中Ric-8活性所需的新蛋白。鉴于苍蝇和人类之间的这些途径的高度保守,这些研究将提供G?12/13蛋白信号转导在血管发育过程中,并将确定新的分子与潜在的治疗重要性,在调节血管生成。
英文摘要
DESCRIPTION (provided by applicant): Heterotrimeric G proteins are important bi-molecular switches that transmit signals from a diverse array of membrane receptors for neurotransmitters, hormones and extracellular morphogens to activate downstream intracellular signaling pathways. Members of the G?12/13 family are particularly important during embryonic development as they are essential for the development of the circulatory system and are required for embryonic angiogenesis. The goal of this proposal is to understand how Ric-8 participates in signaling in the G?12/13 pathway. We will use the Drosophila gastrulation pathway as a model system to study Ric-8 to take advantage of the powerful cell biological tools and rich understanding of the G?12/13 signaling pathway in flies. In this proposal we will 1) Conduct a structure-function study of Ric-8 within the context of G?12/13 signaling; and 2) Identify novel proteins that are required for regulating Ric-8 activity in Drosophila. Given the hih degree of conservation of these pathways between flies and humans, these studies will provide understanding of the regulation of G?12/13 protein signaling during vascular development and will identify novel molecules with potential therapeutic importance in the regulation of angiogenesis.
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会议论文
Single molecule analysis of cytoskeletal cross-linking proteins
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批准号:8568832
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项目类别:
-
资助金额:$7.6万
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财政年份:2013
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负责人:Stephen Rogers
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依托单位:
Single molecule analysis of cytoskeletal cross-linking proteins
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批准号:8705609
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项目类别:
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资助金额:$7.6万
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财政年份:2013
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负责人:Stephen Rogers
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依托单位:
Understanding the role of Ric-8 in Ga 12/13 signaling
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批准号:8711531
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项目类别:
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资助金额:$7.39万
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财政年份:2013
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负责人:Stephen Rogers
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依托单位:
Molecular Mechanisms of Cytoskeletal Regulators
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批准号:8642190
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项目类别:
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资助金额:$27.27万
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财政年份:2011
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负责人:Stephen Rogers
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依托单位:
Molecular Mechanisms of Cytoskeletal Regulators
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批准号:8245010
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项目类别:
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资助金额:$27.32万
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财政年份:2011
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负责人:Stephen Rogers
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依托单位:
Molecular Mechanisms of Cytoskeletal Regulators
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批准号:8107211
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项目类别:
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资助金额:$26.93万
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财政年份:2011
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负责人:Stephen Rogers
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依托单位:
Molecular Mechanisms of Cytoskeletal Regulators
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批准号:8450778
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项目类别:
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资助金额:$26.34万
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财政年份:2011
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负责人:Stephen Rogers
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依托单位:
Mechanisms of cytoskeletal crosstalk during cellular motility
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批准号:7581057
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项目类别:
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资助金额:$26.9万
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财政年份:2008
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负责人:Stephen Rogers
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依托单位:
Mechanisms of cytoskeletal crosstalk during cellular motility
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批准号:8033697
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项目类别:
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资助金额:$26.4万
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财政年份:2008
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负责人:Stephen Rogers
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依托单位:
Mechanisms of cytoskeletal crosstalk during cellular motility
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批准号:7467513
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项目类别:
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资助金额:$25.79万
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财政年份:2008
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负责人:Stephen Rogers
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依托单位:
Mechanisms of cytoskeletal crosstalk during cellular motility
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批准号:7777841
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项目类别:
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资助金额:$26.66万
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财政年份:2008
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负责人:Stephen Rogers
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依托单位:
Mechanisms of cytoskeletal crosstalk during cellular motility
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批准号:8228138
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项目类别:
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资助金额:$26.4万
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财政年份:2008
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负责人:Stephen Rogers
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依托单位:
海外基金