Anatomical and functional modularity of the cerebral cortex

大脑皮层的解剖和功能模块化

• 批准号: 8597150
• 负责人: Manuel F Casanova
• 金额: $ 0.8万
• 依托单位: UNIVERSITY OF LOUISVILLE
• 依托单位国家: 美国
• 财政年份: 2013
• 资助国家: 美国
• 起止时间: 2013-07-23 至 2014-07-22
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8597150
• 关键词: Address; Anatomy; Anthropology; Area; Attention; Attention deficit hyperactivity disorder; Autistic Disorder; Cerebral cortex; Communication; Computer Simulation; Development; Disease; Dyslexia; Electrodes; Electrophysiology (science); Embryology; Epigenetic Process; Focus Groups; Fostering; Future; Genetic; Goals; Health; Human; Knowledge; Logistics; Maps; Mediating; Molecular Neurobiology; Neuroanatomy; Neurobiology; Neurodegenerative Disorders; Neurons; Neurosciences; Participant; Pathology; Phenotype; Physiological; Physiology; Property; Recruitment Activity; Research Personnel; Resolution; Role; Scientific Advances and Accomplishments; Seminal; Stroke; Students; System; Time; Training; Training Programs; Videotape; Work; clinical practice; cognitive function; computational neuroscience; interest; lectures; meetings; neocortical; neural model; neural prosthesis; neurophysiology; parallel processing; programs; public health relevance; relating to nervous system; stem; symposium; synergism

DESCRIPTION (provided by applicant): The R13 mechanism would be used to support a scientific conference, "Anatomical and functional modularity of the cerebral cortex", focusing on recent studies describing the organization of the cerebral cortex from a modular perspective, and how the same provides for translational perspectives into clinical practice. The conference would provide a cohesive forum on the latest anatomical and physiological approaches to understanding the basic components of cortical modularity and their involvement in different pathological states, e.g., autism, dyslexia, and ADHD. It will disseminate, for example, recent work regarding the use of minicolumns as neural prosthetics agents for cases of stroke/neurodegenerative disorders and how timing in neural firing between different layers of a minicolumn may provide for higher cognitive functions. The symposium seeks to encourage communication and in-depth discussion of a broad range of subjects under the unifying theme of cortical modularity. The topics covered at the conference would span a wide spectrum of resolution, that is, from minicolumns and their parcellation into different components (e.g., apica dendritic bundles) all the way to macrocolumns and networks of the same. The sessions of the symposium span four major areas: 1) Anatomy and Development (encompassing both embryology and anatomical compartmentalization of neocortical modules), 2) Anthropology (addressing how encephalization has proceeded through the addition of supernumerary minicolumns), 3) Computer modeling and electrophysiology (emphasizing the minicolumn's prowess for parallel processing and how empirical models of neural connectivity help explain the emergent properties of modules), and 4) Pathology (a discussion of several conditions where abnormalities of minicolumns have been implicated).

描述（由申请人提供）：R13机制将用于支持科学会议“大脑皮层的解剖学和功能模块化”，重点关注从模块化角度描述大脑皮层组织的最新研究，以及如何将其转化为临床实践。会议将提供一个有凝聚力的论坛，讨论最新的解剖学和生理学方法，以了解皮质模块化的基本组成部分及其在不同病理状态中的参与，例如，自闭症，阅读障碍，多动症它将传播，例如，最近的工作，关于使用微柱作为神经修复剂的中风/神经退行性疾病的情况下，以及如何在微柱的不同层之间的神经放电的时间可以提供更高的认知功能。该研讨会旨在鼓励交流和深入讨论的范围广泛的主题下，统一的主题皮质模块化。会议所涵盖的主题将涵盖广泛的分辨率，即从微型柱及其分割到不同的组件（例如，顶端树枝状束）一直延伸到大柱和相同的网络。专题讨论会的会议涵盖四个主要领域：1）解剖学与发育（包括胚胎学和新皮层模块的解剖学划分），2）人类学（说明如何通过增加额外的微柱进行脑化），3）计算机建模和电生理学（强调微柱的并行处理能力，以及神经连接的经验模型如何帮助解释模块的涌现特性），和4）病理学（讨论了涉及微柱异常的几种情况）。