Building a Selective Inhibitory Control Tone in Autism: An rTMS Study

建立自闭症的选择性抑制控制基调：一项 rTMS 研究

• 批准号: 8267109
• 负责人: Manuel F Casanova
• 金额: $ 21.98万
• 依托单位: UNIVERSITY OF LOUISVILLE
• 依托单位国家: 美国
• 财政年份: 2009
• 资助国家: 美国
• 起止时间: 2009-07-01 至 2014-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8267109
• 关键词: Age; Applications Grants; Area; Asperger Syndrome; Autistic Disorder; Autopsy; Axon; Behavioral; Brain; Brain region; Cells; Clinical; Cognitive; Cognitive deficits; Development; Discrimination; Electroencephalography; Environment; Frequencies; Functional disorder; Grant; Interneurons; Intervention; Investigation; Laboratories; Language; Lateral; Link; Long-Term Depression; Magnetism; Measures; Modeling; Neuronal Plasticity; Neuropil; Outcome Measure; Pathology; Patients; Pattern; Persons; Pervasive Child Development Disorders; Population; Prefrontal Cortex; Psychiatric therapeutic procedure; Recruitment Activity; Reporting; Rett Syndrome; Sensory Process; Social Interaction; Source; Stereotyped Behavior; Surface; Symptoms; Techniques; Testing; Therapeutic Intervention; Thinking; Tissues; Transcranial magnetic stimulation; Treatment outcome; functional outcomes; interest; magnetic field; neuropathology; neurophysiology; repetitive transcranial magnetic stimulation; response; sex; social communication; socioeconomics; theories; tool

Project summary Autism is a pervasive developmental disorder of childhood characterized by deficits in social interaction, language, and stereotyped behaviors and restricted range of interests. Recent studies on postmortem tissue suggest that autism is associated with cortical cytoarchitectural abnormalities. In brief, reports on independent populations have shown a reduction in the neuropil space at the periphery of the minicolumn. This is the compartment where lateral inhibition sharpens the borders of minicolumns and increases their definition. The primary source of for this inhibitory effect is derived from axon bundles of double-bouquet cells. The axons of double bouquet cells arrange themselves in essentially repeatable patterns varying between 15 ¿m and 30 ¿m wide, perpendicular to the cortical surface. This grant attempts to preferentially strengthen the inhibitory surround of minicolumns by taking advantage of the geometry of double bouquet cells. We will use the principle of induction to induce electrical currents in double bouquet cells by applying a coil of wire energized by a capacitor (Transcranial Magnetic Stimulator or TMS) to provide a magnetic field orthogonal to the plane of the coil. Slow or low frequency TMS will enhance interneuron inhibition which in turn will enhance spatial contrast needed to optimize functional discrimination in minicolumnar units. The trial will recruit 70 autistic patients and 30 controls matched for age, sex, IQ, and socio-economic class. Outcome measures will include behavioral and electrophysiological measures. Overall, our project will link behavioral, clinical, and neurophysiological (qEEG, ERP) responses during cognitive tests and TMS treatment outcomes with an underlying neuropathology model (minicolumnar pathology and lateral inhibition deficits) derived from investigations in our laboratory. The results of the proposed study will help understand the specific social communication and cognitive deficits associated with developmental abnormalities of functions within cortical circuitry, and thereby contribute to understanding the brain substrates of behavioral dysfunctions typical for autism. The proposal represents a new development in combining TMS with functional outcome measures (cognitive ERP, EEG), using TMS as a theory-guided psychiatric therapy in autism.

项目总结

项目成果

Repetitive Transcranial Magnetic Stimulation (rTMS) Modulates Event-Related Potential (ERP) Indices of Attention in Autism.

• DOI: 10.2478/s13380-012-0022-0
• 发表时间: 2012-06-01
• 期刊: Translational neuroscience
• 影响因子: 2.1
• 作者: Casanova MF;Baruth JM;El-Baz A;Tasman A;Sears L;Sokhadze E
• 通讯作者: Sokhadze E

Behavioral, Cognitive, and Motor Preparation Deficits in a Visual Cued Spatial Attention Task in Autism Spectrum Disorder.

• DOI: 10.1007/s10484-015-9313-x
• 发表时间: 2016-03
• 期刊: Applied psychophysiology and biofeedback
• 影响因子: 3
• 作者: Sokhadze EM;Tasman A;Sokhadze GE;El-Baz AS;Casanova MF
• 通讯作者: Casanova MF

Atypical Processing of Novel Distracters in a Visual Oddball Task in Autism Spectrum Disorder.

• DOI: 10.3390/bs7040079
• 发表时间: 2017-11-16
• 期刊: Behavioral sciences (Basel, Switzerland)
• 作者: Sokhadze EM;Lamina EV;Casanova EL;Kelly DP;Opris I;Khachidze I;Casanova MF
• 通讯作者: Casanova MF

EVENT-RELATED POTENTIAL STUDY OF ATTENTION REGULATION DURING ILLUSORY FIGURE CATEGORIZATION TASK IN ADHD, AUTISM SPECTRUM DISORDER, AND TYPICAL CHILDREN.

• DOI: 10.1080/10874208.2012.650119
• 发表时间: 2012
• 期刊: Journal of neurotherapy
• 作者: Sokhadze EM;Baruth JM;Sears L;Sokhadze GE;El-Baz AS;Williams E;Klapheke R;Casanova MF
• 通讯作者: Casanova MF

Low-frequency repetitive transcranial magnetic stimulation (rTMS) affects event-related potential measures of novelty processing in autism.

• DOI: 10.1007/s10484-009-9121-2
• 发表时间: 2010-06
• 期刊: APPLIED PSYCHOPHYSIOLOGY AND BIOFEEDBACK
• 影响因子: 3
• 作者: Sokhadze, Estate;Baruth, Joshua;Tasman, Allan;Mansoor, Mehreen;Ramaswamy, Rajesh;Sears, Lonnie;Mathai, Grace;El-Baz, Ayman;Casanova, Manuel F.
• 通讯作者: Casanova, Manuel F.