Pilot Project Program

试点项目计划

• 批准号: 8473254
• 负责人: John S Bradley
• 金额: $ 7.23万
• 依托单位: UNIVERSITY OF CALIFORNIA, SAN DIEGO
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/8473254
• 关键词: Address; Advisory Committees; Anti-Bacterial Agents; Area; Attention; Basic Science; Biological Assay; Child; Childhood; Clinical; Clinical Investigator; Clinical Trials; Collaborations; Committee Members; Communicable Diseases; Communication; Data; Development; Excretory function; Fertilization; Fostering; Generations; Goals; Human Development; Incentives; Infant; Infection; Kidney; Knowledge; Link; Modeling; National Institute of Child Health and Human Development; Oats; Pediatrics; Pharmacology; Physiology; Pilot Projects; Plasma; Process; Research; Research Personnel; Research Project Grants; Research Support; Seasons; Specialized Center; Testing; Therapeutic; Training Activity; antimicrobial; base; cathelicidin; cost; cost effective; design; innovation; investigator training; novel; pediatric pharmacology; programs; response

The Pilot Project studies will support the overall program entitled "Developmental and Translational Pharmacology of Pediatric Antimicrobial Therapy", submitted as an application responsive to RFA-HD-10-026: Specialized Center in Research in Pediatric Developmental Pharmacology (RPDP) Program (U54). The overall theme of the proposed program at the UC San Diego is to bring together non-clinical and clinical experts in the fields of developmental physiology, pharmacology, and infectious diseases to advance the field of pediatric developmental pharmacology. To promote the development of innovated research ideas and foster new collaborations, the UC San Diego RPDP Center includes a Pilot Project program. This program supports limited Pilot Projects for 1 or 2 years in duration to generate focused explorations related to existing RPDP Center Projects or to generate preliminary information for new Project applications. These Pilot Projects may originate from within UC San Diego or from other NICHD supported RPDP Centers. Administrative Core will organize the solicitation and selection process and the Scientific Advisory Committee members will assist the PIs and Core Directors with selection. The Pilot Projects that address general developmental pharmacologic issues not specific to antibacterial therapeutics may be considered but must involve either the Pharmacometric Core, the Quantitative Pharmacology Assay Core or both. Projects that promote interactions with other RPDP Centers, support junior investigators and have the potential to provide the scientific basis for larger clinical trials will be encouraged. Two Pilot Projects were selected from an initial pool of applicants for UC San Diego RPDP Center Years 1-2. They are entitled "Plasma and intracellular cathelicidin responses to infection in infants and young children" and "Developmental changes in aminopenicillin renal excretion in infants and young children" and are linked to Projects II and III, respectively. Both of these projects utilize the Pharmacometric and Quantitative Pharmacology Assay Cores and provide opportunities for trainee involvement, as well. In program Years 2-4, solicitations will be made for the Year 3-5 Pilot Projects.

试点项目研究将支持题为“儿科抗菌治疗的发育和转化药理学”的整体项目，该项目作为响应RFA-HD-10-026：儿科发育药理学（RPDP）项目（U 54）研究专门中心的申请提交。该计划的总体主题是汇集发育生理学，药理学和传染病领域的非临床和临床专家，以推进儿科发育药理学领域。为了促进创新研究理念的发展并促进新的合作，UC San Diego RPDP中心包括一个试点项目计划。该计划支持有限的试点项目，为期1或2年，以产生与现有RPDP中心项目相关的重点探索，或为新项目申请产生初步信息。这些试点项目可能来自加州大学圣地亚哥分校或其他NICHD支持的RPDP中心。行政核心将组织征集和选择过程，科学咨询委员会成员将协助PI和核心主任进行选择。可以考虑解决一般开发药理学问题的试点项目，这些问题不限于抗菌治疗，但必须涉及药理学核心、定量药理学试验核心或两者。促进与其他RPDP中心互动的项目， 将鼓励初级研究人员，并有潜力为更大规模的临床试验提供科学依据。两个试点项目是从加州大学圣地亚哥分校RPDP中心第1-2年的初始申请人中选出的。这两个项目的标题分别是“婴儿和幼儿血浆和细胞内cathelicidin对感染的反应”和“婴儿和幼儿肾排泄氨基青霉素的发育变化”，分别与项目二和项目三有关。这两个项目都利用了药理学和定量药理学分析核心，并为学员参与提供了机会。在项目第2-4年，将为第3-5年的试点项目进行招标。