Pilot Project Program

试点项目研究将支持作为对RFA-HD-10-026：儿科发展药理学(RPDP)专门研究中心计划(U54)的响应而提交的名为“儿科抗菌治疗的发展和转化性药理学”的整体计划。加州大学圣地亚哥分校拟议项目的总体主题是将发育生理学、药理学和传染病领域的非临床和临床专家聚集在一起，推动儿科发育药理学领域的发展。为了促进创新研究思路的发展和促进新的合作，加州大学圣地亚哥分校RPDP中心包括一个试点项目计划。该计划支持为期1到2年的有限试点项目，以生成与现有RPDP中心项目相关的重点探索，或为新的项目申请生成初步信息。这些试点项目可能来自加州大学圣地亚哥分校或NICHD支持的其他RPDP中心。行政核心将组织征集和遴选过程，科学咨询委员会成员将协助私人投资主任和核心主任进行遴选。解决一般发育药理学问题的试点项目可以被考虑，但必须涉及药理计量核心、定量药理分析核心或两者兼有。促进与其他RPDP中心互动的项目，支持 将鼓励初级研究人员，并有可能为更大规模的临床试验提供科学基础。两个试点项目是从加州大学圣地亚哥分校RPDP中心1-2年级的初始申请者中挑选出来的。它们的标题分别是“婴幼儿对感染的血浆和细胞内排泄素反应”和“婴幼儿肾排泄中氨基青霉素的发育变化”，并分别与项目二和项目三相联系。这两个项目都利用了药理计量和定量药理分析核心，并为学员的参与提供了机会。在计划的第二至第四年，将为第三至第五年的试点项目进行征集。

The Pilot Project studies will support the overall program entitled "Developmental and Translational Pharmacology of Pediatric Antimicrobial Therapy", submitted as an application responsive to RFA-HD-10-026: Specialized Center in Research in Pediatric Developmental Pharmacology (RPDP) Program (U54). The overall theme of the proposed program at the UC San Diego is to bring together non-clinical and clinical experts in the fields of developmental physiology, pharmacology, and infectious diseases to advance the field of pediatric developmental pharmacology. To promote the development of innovated research ideas and foster new collaborations, the UC San Diego RPDP Center includes a Pilot Project program. This program supports limited Pilot Projects for 1 or 2 years in duration to generate focused explorations related to existing RPDP Center Projects or to generate preliminary information for new Project applications. These Pilot Projects may originate from within UC San Diego or from other NICHD supported RPDP Centers. Administrative Core will organize the solicitation and selection process and the Scientific Advisory Committee members will assist the PIs and Core Directors with selection. The Pilot Projects that address general developmental pharmacologic issues not specific to antibacterial therapeutics may be considered but must involve either the Pharmacometric Core, the Quantitative Pharmacology Assay Core or both. Projects that promote interactions with other RPDP Centers, support junior investigators and have the potential to provide the scientific basis for larger clinical trials will be encouraged. Two Pilot Projects were selected from an initial pool of applicants for UC San Diego RPDP Center Years 1-2. They are entitled "Plasma and intracellular cathelicidin responses to infection in infants and young children" and "Developmental changes in aminopenicillin renal excretion in infants and young children" and are linked to Projects II and III, respectively. Both of these projects utilize the Pharmacometric and Quantitative Pharmacology Assay Cores and provide opportunities for trainee involvement, as well. In program Years 2-4, solicitations will be made for the Year 3-5 Pilot Projects.