Pilot Project Program

该试点项目研究将支持名为“儿童抗菌药物治疗的发展和转化药理学”的整体项目，该项目作为RFA-HD-10-026：儿童发展药理学研究专业中心（RPDP）项目（U54）的申请提交。加州大学圣地亚哥分校拟议项目的总体主题是汇集发育生理学、药理学和传染病领域的非临床和临床专家，以推进儿科发育药理学领域的发展。为了促进创新研究理念的发展和促进新的合作，加州大学圣地亚哥分校RPDP中心包括一个试点项目计划。该计划支持有限的试点项目，持续时间为1或2年，以产生与现有RPDP中心项目相关的重点探索或为新项目申请生成初步信息。这些试点项目可能来自加州大学圣地亚哥分校或其他NICHD支持的RPDP中心。行政核心将组织征集和遴选过程，科学咨询委员会成员将协助项目负责人和核心主任进行遴选。可以考虑解决一般发展药理学问题的试点项目，而不是针对抗菌治疗，但必须涉及药物计量学核心，定量药理学分析核心或两者兼有。支持促进与其他RPDP中心互动的项目

The Pilot Project studies will support the overall program entitled "Developmental and Translational Pharmacology of Pediatric Antimicrobial Therapy", submitted as an application responsive to RFA-HD-10-026: Specialized Center in Research in Pediatric Developmental Pharmacology (RPDP) Program (U54). The overall theme of the proposed program at the UC San Diego is to bring together non-clinical and clinical experts in the fields of developmental physiology, pharmacology, and infectious diseases to advance the field of pediatric developmental pharmacology. To promote the development of innovated research ideas and foster new collaborations, the UC San Diego RPDP Center includes a Pilot Project program. This program supports limited Pilot Projects for 1 or 2 years in duration to generate focused explorations related to existing RPDP Center Projects or to generate preliminary information for new Project applications. These Pilot Projects may originate from within UC San Diego or from other NICHD supported RPDP Centers. Administrative Core will organize the solicitation and selection process and the Scientific Advisory Committee members will assist the PIs and Core Directors with selection. The Pilot Projects that address general developmental pharmacologic issues not specific to antibacterial therapeutics may be considered but must involve either the Pharmacometric Core, the Quantitative Pharmacology Assay Core or both. Projects that promote interactions with other RPDP Centers, support junior investigators and have the potential to provide the scientific basis for larger clinical trials will be encouraged. Two Pilot Projects were selected from an initial pool of applicants for UC San Diego RPDP Center Years 1-2. They are entitled "Plasma and intracellular cathelicidin responses to infection in infants and young children" and "Developmental changes in aminopenicillin renal excretion in infants and young children" and are linked to Projects II and III, respectively. Both of these projects utilize the Pharmacometric and Quantitative Pharmacology Assay Cores and provide opportunities for trainee involvement, as well. In program Years 2-4, solicitations will be made for the Year 3-5 Pilot Projects.