Immunobiology of Trauma

创伤免疫生物学

• 批准号: 9217919
• 负责人: Daniel G. Remick
• 金额: $ 15.57万
• 依托单位: BOSTON UNIVERSITY MEDICAL CAMPUS
• 依托单位国家: 美国
• 财政年份: 2010
• 资助国家: 美国
• 起止时间: 2010-07-01 至 2022-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9217919
• 关键词: Immunobiology; Trauma

This T32 grant, GM86308, Immunobiology of Trauma will provide the appropriate training and mentoring to create the next generation of physician scientists. Physician-scientists are a critical element of the workforce necessary to improve the health of patients. Injuries and deaths from traumatic injury represented the major cause of death and impaired function among people under the age of 44. This morbidity and mortality creates a disproportionate drain on healthcare resources due to the typical young age of the trauma patient. Additionally, new advances in identifying the scope of chronic traumatic encephalopathy (football players’ brain injury) show the need for increased investment in the basic science of trauma. Trauma disproportionately affects underserved minority patients resulting in healthcare disparities further emphasizing the role trauma plays in the health of our country. This revision of our competing renewal will build on the success of the prior five years of funding. These successes include effective recruitment of minority physicians into the program, 6 national awards to our T32 fellows, and 23 papers either published or in press. Since the original renewal submission in 2015 an additional 11 papers have been published or are in press. There are important innovations in this competing renewal which developing new evaluation tools developed by the recently funded BU Clinical Science and Translational Institute and a newly NIH funded mentoring program for minority students, among others. Some of the significant changes in the new application include a restructuring of the executive committee to include members with active funding and labs, development of clear training objectives, and expansion of the training faculty to include investigators focusing on traumatic brain injury. This grant specifically requests funding for two postdoctoral fellows for two years of training, a formula which has proven successful during the prior funding. The Executive Committee works closely with the individual trainees to identify labs whose research matches the interests of the trainees. All of our prior trainees have been drawn from the residency programs at Boston Medical Center, the largest safety net hospital in New England. There is exceptional institutional commitment manifest by the support for the recruitment and retention of minority physicians and trainees with disabilities. It should be noted that only one of our 10 trainees has completed their clinical training, and it is not possible to document successful physician scientists completing our program. However, we have prepared our trainees for academic careers by mentoring their science such that they have already been successful as documented by the numerous national awards and published multiple manuscripts in the peer reviewed literature.

这个T32赠款，GM86308，创伤免疫生物学将提供适当的培训， 培养下一代医学科学家。科学家是一个关键的 改善患者健康所需的劳动力要素。伤亡人数 创伤是造成人们死亡和功能受损的主要原因， 年龄在44岁以下。这种发病率和死亡率对医疗保健造成了不成比例的消耗 由于创伤患者的典型年轻年龄，此外，新的进展 确定慢性创伤性脑病（足球运动员脑损伤）的范围显示 需要增加对创伤基础科学的投资。创伤不成比例 影响服务不足的少数民族患者，导致医疗保健差距进一步强调， 创伤在我们国家的健康中所起的作用。我们的竞争更新的这个修订将建立 过去五年的成功融资。这些成功包括有效的招聘 少数民族医生进入该计划，6个国家奖给我们的T32研究员，和23篇论文 无论是出版还是印刷。自2015年首次更新申请以来， 论文已发表或正在出版。在这场竞争中有重要的创新 更新，开发由最近资助的BU Clinical开发的新评估工具 科学和转化研究所和一个新的国家卫生研究院资助的少数民族指导计划 学生，其中。新应用程序中的一些重大更改包括 重组执行委员会，以包括有积极资金和实验室的成员， 制定明确的培训目标，扩大培训师资队伍， 专注于创伤性脑损伤的研究人员该基金特别要求资助两个 博士后研究员两年的培训，这一公式已被证明是成功的， 前期融资。执行委员会与学员个人密切合作， 他们的研究符合受训者的兴趣我们之前所有的学员都被抽中了 波士顿医疗中心是纽约最大的安全网医院， 英格兰对《公约》的支持体现了特殊的体制承诺， 招聘和留住少数民族残疾医生和受训人员。应当注意 我们的10名学员中只有一人完成了临床培训， 记录成功的医生科学家完成我们的计划。但是，我们已经准备好了 我们的学员的学术生涯，指导他们的科学，使他们已经 成功的，因为记录了许多国家奖项和出版多个 同行评审文献中的手稿。