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The role of stress and FoxP2 in adult vocal learning: tests using a parrot model

压力和 FoxP2 在成人声音学习中的作用：使用鹦鹉模型进行测试

基本信息

批准号：
8465889
负责人：
TIMOTHY F WRIGHT
金额：
$ 23.21万
依托单位：
NEW MEXICO STATE UNIVERSITY LAS CRUCES
依托单位国家：
美国
项目类别：
财政年份：
2010
资助国家：
美国
起止时间：
2010-06-25 至 2015-05-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/8465889
关键词：
Adolescent Adult Animal Model Area Asthma Automobile Driving Behavioral Behavioral Assay Biomedical Research Birds Brain Caring Child Childhood Cognitive Communication Corticosterone Dental Care Development Disease Endocrine Evolution Exhibits Family Psittacidae Female Funding Future Gene Expression General Population Genes Genetic HIV Health Health Personnel Heart failure Hormones Human Immigrant Immigration Immunization Individual Language Language Development Learning Life Malignant Neoplasms Measures Melopsittacus Mental Health Services Methodology Minority-Serving Institution Modeling Monitor Neuroanatomy Non-Insulin-Dependent Diabetes Mellitus Obesity Pattern Perception Physiological Population Process Production Productivity Relative (related person)Role Route Series Services Sex Characteristics Signal Transduction Social Development Social Environment Songbirds Staging Stress Testing United States Women&apos s Group age effect critical period design driving force experience fitness health disparity improved insight male neuromechanism novel public health relevance research and development research study response sex social social group social stress tool vocal learning vocalization

项目摘要

DESCRIPTION (provided by applicant): PROJECT ABSTRACT In the United States, immigrant populations suffer significant health disparities relative to the general population. Immigrants experience higher rates of some diseases and stress-related conditions, and have lower rates of access to preventative care and services. Numerous studies have identified a lack of English-speaking abilities in adult immigrants as the primary factor driving these health disparities. Improving rates of language learning by adult immigrants and their health care providers are obvious routes to reducing these disparities. Yet there are many questions regarding adult language learning, particularly in regards to the social forces that drive or inhibit learning, and the physiological and neural mechanisms that underlie learning and production. There is increasing evidence that these mechanisms are different in adults than they are in children, but songbirds, the primary animal model for vocal learning, generally do not exhibit vocal learning as adults. The proposed studies would develop the budgerigar, a small parrot, as an alternative animal model for vocal learning. Budgerigars of both sexes are capable of vocal learning as adults and individuals will readily converge to a shared group-specific contact call when moved from one social group to another. This project will utilize this vocal convergence as a behavioral assay of adult vocal learning in a series of experiments designed to test i) the effects of social context and vocal convergence on endocrine stress levels, ii) the effects of manipulated corticosterone (the primary stress hormone in birds) on learning in juveniles and adults, and iii) the role of the gene FoxP2 in learning in juveniles and adults. The first series of experiments will move individuals from one social group to another and monitor corticosterone levels to test the password hypothesis for the function of group-specific vocalizations. The second series of experiments will alter corticosterone levels at both the juvenile and adult stage to test for organizational and activational effects of corticosterone on vocal learning. The third will examine expression patterns of FoxP2, a gene implicated in vocal learning in both humans and songbirds, in the vocal learning centers of the brains of juvenile and adult budgerigars. Together, these experiments will provide novel and potentially transformative insights regarding the vocal learning process in adults and how it differs from learning in juveniles. This SC1 funding will also contribute to the professional development of the PI and enhance biomedical research at a minority serving institution. PUBLIC HEALTH RELEVANCE: PROJECT NARRATIVE Immigrants in the US experience health disparities that result from a lack of English-speaking abilities. This project will examine the effects of social context and stress in an animal model for adult vocal learning, the budgerigar. It will also investigate the physiological and genetic mechanisms that underlie adult vocal learning.

描述（由申请人提供）：项目摘要在美国，移民人口遭受显着的健康差距相对于一般人口。移民患某些疾病和与压力有关的疾病的比率较高，获得预防保健和服务的比率较低。许多研究表明，成年移民缺乏英语能力是造成这些健康差异的主要因素。提高成年移民及其医疗保健提供者的语言学习率是减少这些差距的明显途径。然而，关于成人语言学习，特别是关于驱动或抑制学习的社会力量，以及学习和产生的生理和神经机制，还有许多问题。越来越多的证据表明，这些机制在成年人中与儿童不同，但鸣禽，主要的动物模型，声音学习，通常不表现出声音学习作为成年人。拟议的研究将开发虎皮鹦鹉，一种小鹦鹉，作为替代动物模型的声音学习。雄性和雌性的虎皮鹦鹉都有声音学习的能力，当它们从一个社会群体转移到另一个社会群体时，个体会很容易地聚集到一个共享的群体特定的联系呼叫。该项目将利用这种声音会聚作为一系列实验中成年人声音学习的行为测定，旨在测试i）社会背景和声音会聚对内分泌应激水平的影响，ii）操纵皮质酮（鸟类中的主要应激激素）对青少年和成年人学习的影响，以及iii）基因FoxP2在青少年和成年人学习中的作用。第一系列实验将把个体从一个社会群体转移到另一个社会群体，并监测皮质酮水平，以检验群体特异性发声功能的密码假设。第二个系列的实验将改变皮质酮水平在青少年和成人阶段测试组织和激活的皮质酮对声乐学习的影响。第三部分将研究FoxP2的表达模式，FoxP2是一种与人类和鸣禽的声音学习有关的基因，在幼年和成年虎皮鹦鹉大脑的声音学习中心。总之，这些实验将提供新的和潜在的变革性见解，关于成人的声乐学习过程，以及它如何不同于青少年的学习。这SC1资金也将有助于PI的专业发展，并加强在少数民族服务机构的生物医学研究。公共卫生相关性：项目叙述在美国的移民经历的健康差距，由于缺乏英语能力。本计画将以虎皮鹦鹉为成人发声学习的动物模型，探讨社会环境与压力的影响。它还将调查生理和遗传机制，成人声乐学习的基础。