A longitudinal Study of CA-MRSA Nasal Colonization in College Sports Participants

大学体育参与者CA-MRSA鼻定植的纵向研究

• 批准号: 8134710
• 负责人: Clarence Buddy Creech
• 金额: $ 5万
• 依托单位: VANDERBILT UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2010
• 资助国家: 美国
• 起止时间: 2010-09-07 至 2011-09-06
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8134710
• 关键词: Adolescent; Adult; Affect; Ambulatory Care Facilities; Animal Model; Anterior nares; Antibiotic Resistance; Antibiotics; Athletic; Blood; Characteristics; Child; Childhood; Clinical; Clinical Research; Communities; Complement; Data; Development; Disease; Disease Outbreaks; Drainage procedure; Epidemiology; Event; Frequencies; General Population; Genes; Genetic; Goals; Human; Iceberg; Individual; Infection; Infectious Diseases Research; Knowledge; Laboratory Research; Libraries; Link; Longitudinal Studies; Mentorship; Methicillin; Molecular Epidemiology; Morbidity - disease rate; Nose; Organism; Participant; Pathogenesis; Patients; Population; Prevention strategy; Redness; Research Personnel; Resistance; Risk; Risk Factors; Role; Seasons; Site; Skin; Soft Tissue Infections; Soft Tissue Injuries; Sports; Staphylococcal Infections; Staphylococcus aureus; Students; Swelling; Testing; Time; Training; Universities; Virulence; Virulence Factors; Work; base; cohort; college; comparative genomics; epidemiology study; experience; high risk; improved; interest; member; methicillin resistant Staphylococcus aureus; microbial; mortality; novel; programs; research study; soft tissue; university student; young adult

DESCRIPTION (provided by applicant): Staphylococcus aureus colonizes the anterior nares of nearly one-third of people and is the leading cause of skin and soft tissue infections in children and adults. Treatment of staphylococcal infections has become more challenging due to the emergence of community-associated methicillin-resistant S. aureus (CA-MRSA) organisms. In addition to the rise in infections due to CA-MRSA, asymptomatic nasal carriage with CA-MRSA also has increased. Specific groups appear to be at increased risk for CA-MRSA infections, such as adolescents, young adults, and sports team participants. As a result of the high morbidity and occasional mortality seen with CA-MRSA, we need to better understand what factors contribute to colonization and disease with this organism. Based on our preliminary data suggesting that infecting strains of CA-MRSA represent a subset of colonizing CA-MRSA strains, we hypothesize that CA-MRSA nasal colonization increases the risk for CA-MRSA infections, but only when the colonization strain expresses one or more virulence factors that promote the development of clinical disease. The overall goal of this proposal is to precisely define the epidemiology of S. aureus nasal carriage and subsequent risk for S. aureus infections. We have selected a population of college student-athletes, considered to be at higher risk for skin and soft tissue infections than the general population. Three integrated specific aims are proposed: 1) To prospectively determine the frequency of nasal carriage of S. aureus and CA-MRSA in a cohort of healthy sports team participants during the course of two seasons; 2) to define the frequency of clinical staphylococcal infections with CA-MRSA and methicillin-susceptible S. aureus (MSSA) in the team members; and 3) to identify the microbial factors associated with nasal colonization and infection. This proposal is a natural extension of our earlier work studying nasal colonization with CA-MRSA in the pediatric population. It will be guided by an experienced mentorship team and will complement my training in pediatric infectious diseases, laboratory research, and epidemiology. Furthermore, the proposal supports my efforts to become an independent investigator defining the clinical and molecular epidemiology of staphylococcal carriage and disease.

描述（由申请人提供）：金黄色葡萄球菌在近三分之一的人的前鼻孔定植，是儿童和成人皮肤和软组织感染的主要原因。由于社区相关耐甲氧西林葡萄球菌的出现，葡萄球菌感染的治疗变得更具挑战性。金黄色葡萄球菌（CA-MRSA）微生物。除了由于CA-MRSA引起的感染增加外，CA-MRSA的无症状鼻携带也增加了。特定群体感染CA-MRSA的风险似乎更高，例如青少年、年轻人和运动队参与者。由于CA-MRSA的高发病率和偶尔的死亡率，我们需要更好地了解哪些因素导致这种微生物的定植和疾病。 基于我们的初步数据表明，感染菌株的CA-MRSA代表一个子集的殖民CA-MRSA菌株，我们假设，CA-MRSA鼻腔定植增加的风险CA-MRSA感染，但只有当定植菌株表达一个或多个毒力因子，促进临床疾病的发展。该提案的总体目标是精确定义S.金黄色葡萄球菌鼻携带和随后的S.金黄色葡萄球菌感染我们选择了一群大学生运动员，他们被认为比普通人群有更高的皮肤和软组织感染风险。本研究提出了三个具体目标：（1）前瞻性地确定S.金黄色葡萄球菌和CA-MRSA在一个队列的健康运动队参与者在两个赛季的过程中; 2）确定的频率与CA-MRSA和甲氧西林敏感的S.金黄色葡萄球菌（MSSA）的团队成员;和3）确定与鼻腔定植和感染相关的微生物因素。 该建议是我们早期研究儿科人群中CA-MRSA鼻腔定植的工作的自然延伸。它将由一个经验丰富的导师团队指导，并将补充我在儿科传染病，实验室研究和流行病学方面的培训。此外，该提案支持我努力成为一名独立的研究者，定义葡萄球菌携带和疾病的临床和分子流行病学。

项目成果

Association Between Contact Sports and Colonization with Staphylococcus aureus in a Prospective Cohort of Collegiate Athletes.

未来的大学运动员群体中接触运动与金黄色葡萄球菌定植之间的关联。

• DOI: 10.1007/s40279-016-0618-6
• 发表时间: 2017
• 期刊: Sports medicine (Auckland, N.Z.)
• 作者: Jiménez-Truque,Natalia;Saye,ElizabethJ;Soper,Nicole;Saville,BenjaminR;Thomsen,Isaac;Edwards,KathrynM;Creech,CBuddy
• 通讯作者: Creech,CBuddy