RANDOMIZED INTERVENTION FOR CHILDREN WITH VESICOURETERAL REFLUX (RIVUR)

这个子项目是许多研究子项目中利用 资源由NIH/NCRR资助的中心拨款提供。子项目和 调查员(PI)可能从NIH的另一个来源获得了主要资金， 并因此可以在其他清晰的条目中表示。列出的机构是 该中心不一定是调查人员的机构。 RIVUR研究是一项随机、双盲、安慰剂对照的多中心研究，将纳入有发热/症状性尿路感染(F/S尿路感染)和膀胱输尿管返流(VUR)的儿童。参与者被随机接受安慰剂或研究药物(即标准的尿路感染预防抗生素磺胺甲恶唑-甲氧普林)，并接受为期两年的监测，以评估肾脏瘢痕形成和复发性尿路感染的发展。血液和尿液标本的采集、处理和包装服务被要求从CNMC儿科GCRC获得，用于CNMC泌尿外科进行的这项临床研究。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. The RIVUR study is a randomized, double-blind, placebo-controlled, multi-center study that will enroll children with febrile/symptomatic urinary tract infection (F/S UTI) and vesicoureteral reflux (VUR). Participants are randomized to receive placebo or study drug (i.e. Sulfamethoxazole-Trimethoprim, the standard UTI prophylactic antibiotic), and are monitored for a 2 year period to evaluate the development of renal scarring and recurrent UTIs. Blood and urine specimen collection, processing, and packaging services were requested from the CNMC Pediatric GCRC for this clinical research study being conducted by the CNMC Division of Urology.