Partnerships for Biomedical Research in Arkansas

该提案将继续阿肯色州IDEA生物医学研究卓越网络（INBRE）的目标，以扩大阿肯色州的生物医学研究能力。在INBRE第一阶段开发的基础设施的基础上，该州三个研究密集型的领先机构--阿肯色州医学科学大学、阿肯色州费耶特维尔大学和位于小石城的阿肯色州大学--将提供科学领导。来自六所本科院校的13名研究人员和教师将与他们在牵头机构的导师合作，在细胞信号传导、生长和分化的总体主题下进行研究。行政核心将协调所有阿肯色州INBRE活动，并促进这13名调查人员的研究成果。全州本科生研究人员之间的互动将由所有INBRE教师和学生参加的年度会议突出。阿肯色州INBRE将继续致力于为代表性不足的群体扩大机会。INBRE将与多样性事务中心和学校合作，推进新的NIH资助的学生多样性最大化倡议（IMSD）计划的目标，以增加少数民族学生在UAMS完成生物医学科学研究生学位的人数。INBRE参与者之间的交流将由通过Internet 2连接的Access Grid Studios提供便利。生物信息学核心将是全州范围内的研究和教育资源，使本科教师和学生能够获得多学科生物医学研究所需的计算工具。该中心还将与杰克逊州立大学（一所密西西比RCMI）开展学生交流，合作开展一项非裔美国人心血管疾病的长期研究。阿肯色州INBRE还将支持由蛋白质组学、数字显微镜和DNA损伤/毒理学设施组成的科学研究核心。这将使研究人员能够获得在小型机构难以建立的复杂仪器和技术专长。外展核心将提供指导夏季研究机会，非INBRE本科教师和学生在整个国家。通过进一步加强研究基础设施，特别是在本科院校，阿肯色州INBRE将提高学术研究人员竞争联邦资金的能力，增加选择生物医学研究职业的本科生人数，并刺激阿肯色州生物技术产业的增长。

This proposal will continue the goals of the Arkansas IDeA Network for Biomedical Research Excellence (INBRE) to expand biomedical research capacity in Arkansas. Building upon infrastructure developed during the first INBRE phase, three research-intensive, lead institutions in the state-the University of Arkansas for Medical Sciences; the University of Arkansas, Fayetteville, and the University of Arkansas at Little Rock-will provide scientific leadership. Thirteen investigators, faculty from six undergraduate institutions, in collaboration with their mentors at the lead institutions, will conduct research under the overall theme of Cellular Signaling, Growth, and Differentiation. The Administrative Core will coordinate all Arkansas INBRE activities and facilitate the research accomplishments of these 13 investigators. The interactions among undergraduate researchers across the state will be highlighted by an annual conference attended by all INBRE faculty and students. The Arkansas INBRE will continue its commitment to expand opportunities for underrepresented groups. The INBRE will partner with the Center for Diversity Affairs and the School in advancing the goals of the newly NIH-funded Initiative for Maximizing Student Diversity (IMSD) Program to increase the numbers of minority students completing graduate degrees in the biomedical sciences at UAMS. Communication among INBRE participants will be facilitated by Access Grid Studios linked through Internet2. The Bioinformatics Core will be a statewide research and educational resource to give undergraduate faculty and student's access to the computational tools needed for multidisciplinary biomedical research. This Core will also host a student exchange with Jackson State University (a Mississippi RCMI) to collaborate in a long-term study of cardiovascular disease in African Americans. The Arkansas INBRE will also support a Science Research Core consisting of proteomics, digital microscopy and DNA damage/toxicology facilities. These will provide investigators access to sophisticated instrumentation and technical expertise difficult to establish at a small institution. The Outreach Core will offer mentored summer research opportunities to non-INBRE undergraduate faculty and students throughout the state. Through further enhancement of research infrastructure, particularly at undergraduate Institutions, the Arkansas INBRE will improve the ability of academic researchers to compete for federal funding, increase the number of undergraduate students who choose careers in biomedical research, and stimulate the growth of biotechnical industries in Arkansas.