PARTNERSHIPS FOR BIOMEDICAL RESEARCH IN ARKANSAS: SCIENCE RESEARCH CORE

阿肯色州生物医学研究伙伴关系：科学研究核心

• 批准号: 8359806
• 负责人: Helen Benes
• 金额: $ 37.19万
• 依托单位: UNIV OF ARKANSAS FOR MED SCIS
• 依托单位国家: 美国
• 财政年份: 2011
• 资助国家: 美国
• 起止时间: 2011-05-01 至 2012-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8359806
• 关键词: Address; Area; Arkansas; Bioinformatics; Biomedical Research; Biotechnology; Cell Death; Cells; Commit; Core Facility; DNA Damage; DNA Sequence; Data; Data Analyses; Data Collection; Educational workshop; Equipment; Extramural Activities; Faculty; Fellowship Program; Flow Cytometry; Funding; Funding Agency; Genomics; Goals; Grant; Information Technology; Institution; Kentucky; Laboratories; Laboratory Research; Lead; Letters; Mentors; Microscopy; National Center for Research Resources; Participant; Principal Investigator; Proteomics; Research; Research Infrastructure; Research Personnel; Research Project Grants; Resources; Science; Services; Source; Students; Technical Expertise; Techniques; Technology; Tissues; Toxic effect; Toxicology; Training; United States National Institutes of Health; Universities; cell injury; cost; data management; digital; instrumentation; macromolecule; outreach; programs; protein structure; protein structure function; research facility; tool

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. Primary support for the subproject and the subproject's principal investigator may have been provided by other sources, including other NIH sources. The Total Cost listed for the subproject likely represents the estimated amount of Center infrastructure utilized by the subproject, not direct funding provided by the NCRR grant to the subproject or subproject staff. SCIENCE RESEARCH CORE The Arkansas INBRE proposes to continue its Science Research Core, which will comprise services offered by three scientific research facilities at two lead institutions. These core facilities will provide investigators throughout the state with access to the instrumentation and expertise needed for three key areas of modern biotechnologyproteomics, digital microscopy, and DNA damage and toxicology. These three areas were chosen because the technical expertise and, especially, the instrumentation of each facility are not commonly available, even in an average, well-funded research laboratory, particularly not at four-year PUIs. These three facilities were especially chosen to address the specific needs of the 13 Arkansas INBRE Project Leaders (see Table 11). With access to these technologies for specific studies, researchers can then pursue and extend research projects in their own laboratories. The use of these facilities should help researchers obtain necessary preliminary data to apply for extramural research funding. Arkansas INBRE support for the Science Research Core and its three facilities is primarily intended to guarantee access to these facilities by PUI investigators (both faculty and students). This support is not sufficient to completely sustain these facilities, which derive additional, more substantial support from other grant funding sources and from the institutions at which they are located (UAMS and UAF). The three facilities, described in detail below, have the goal of providing expertise and equipment for the following purposes: + Proteomics: To enable researchers to study protein structure and function using state-of-the-art instrumentation; + Digital Microscopy: To allow researchers to locate macromolecules within cells and tissues, thereby better assessing their function in normal and diseased states; and + DNA Damage and Toxicology: To allow researchers to incorporate DNA damage and toxicity analyses (as in cell injury and death) into their studies of normal and diseased cells and tissues. Each Science Research Core facility will also be committed to educating and training Arkansas INBRE faculty and students at both partner and non-partner PUIs, in sophisticated technologies specific to each facility. Hence, all facilities will provide workshops or demonstration sessions relevant to the instrumentation and expertise available. These offerings will be organized by leaders of all Science Research Core facilities and publicized by the Administrative Core statewide. The Science Research Core will also provide access to other Core Facilities located at the lead institutions, for example, DNA Sequencing and Flow Cytometry, for all researchers within the Arkansas INBRE. In addition, through the INBRE consortium, the Arkansas INBRE will network with other INBREs to obtain access to facilities that may not currently be available in Arkansas (see http://louisville.edu/research/genomics/content/microarray_services.shtml and letter of support from the directors of the Kentucky INBRE and the University of Louisville Microarray Facility, Louisville, KY). The Science Research Core is also committed to assisting both student and faculty participants in the Summer Mentored Research Fellowship Program (see Outreach Core), enabling summer fellows to become familiar with technologies that facilitate modern biomedical research and, ultimately, to participate more fully in the INBRE program. As evidence of this commitment, faculty investigators at non-partner PUIs have been using the current INBRE facilities (see below under each facility). Workshops offered during the summer introduce researchers from across the state to available, state-of-the-art technologies. All facilities within the Science Research Core will interact as needed with the Bioinformatics Core to provide for the needs of the Arkansas INBRE partner PUIs (see Objectives, Bioinformatics Core). At present, one of the most daunting aspects of biomedical research concerns data management and bioinformatics tools for analysis. For proteomics research, data collection for protein structure determination requires new information technologies (protein informatics) to analyze and interpret the data. Faculty associated with the Bioinformatics Core will be available to provide the requisite expertise for data analysis, including more conventional statistical analysis of all types of data and analysis of data generated by microarray or proteomics techniques.

该副本是利用资源的众多研究子项目之一 由NIH/NCRR资助的中心赠款提供。对该子弹的主要支持 而且，副投影的主要研究员可能是其他来源提供的 包括其他NIH来源。 列出的总费用可能 代表subproject使用的中心基础架构的估计量， NCRR赠款不直接向子弹或副本人员提供的直接资金。 科学研究核心 阿肯色州的Inbre提议继续其科学研究核心，该核心将包括由两个主要机构的三个科学研究设施提供的服务。这些核心设施将为整个州的调查人员提供获得现代生物技术蛋白质组学，数字显微镜以及DNA损伤和毒理学所需的三个关键领域所需的仪器和专业知识。之所以选择这三个领域，是因为即使在平均，资金良好的研究实验室，尤其是在四年的PUI中，即使在平均，资金充足的研究实验室中，每个设施的仪器都无法使用，尤其是每个设施的工具。特别选择了这三个设施来满足13个阿肯色近亲项目领导者的特定需求（见表11）。借助这些技术进行特定研究，研究人员可以在自己的实验室中追求并扩展研究项目。这些设施的使用应有助于研究人员获得必要的初步数据，以申请校外研究资金。阿肯色州的INBRE对科学研究核心及其三个设施的支持主要旨在保证PUI调查人员（包括教职员工和学生）访问这些设施。这种支持不足以完全维持这些设施，从而获得了其他赠款资金来源以及它们所在的机构（UAMS和UAF）的额外更大的支持。 下面详细描述的三个设施的目的是为以下目的提供专业知识和设备： +蛋白质组学：使研究人员能够使用最先进的仪器研究蛋白质结构和功能； +数字显微镜：允许研究人员在细胞和组织中定位大分子，从而更好地评估其在正常和患病状态的功能；和 + DNA损伤和毒理学：使研究人员能够将DNA损伤和毒性分析（如细胞损伤和死亡）纳入对正常和患病细胞和组织的研究中。 每个科学研究核心设施还将致力于在每个设施的精致技术中教育和培训合作伙伴和非合作伙伴PUI的阿肯色州INBRE教师和学生。因此，所有设施将提供与可用仪器和专业知识相关的研讨会或演示会议。这些产品将由所有科学研究核心设施的领导人组织，并由全州行政核心宣传。 科学研究核心还将为阿肯色州inbre中的所有研究人员提供对位于主要机构的其他核心设施的访问权限，例如DNA测序和流式细胞仪。 In addition, through the INBRE consortium, the Arkansas INBRE will network with other INBREs to obtain access to facilities that may not currently be available in Arkansas (see http://louisville.edu/research/genomics/content/microarray_services.shtml and letter of support from the directors of the Kentucky INBRE and the University of Louisville Microarray Facility,肯塔基州路易斯维尔）。 科学研究核心还致力于协助学生和教职员工参加夏季指导的研究奖学金计划（请参阅外展核心），使夏季研究员能够熟悉促进现代生物医学研究的技术，并最终更全面地参与近亲计划。作为这一承诺的证据，非合伙人PUI的教师调查员一直在使用当前的近亲设施（请参见下面的每个设施）。夏季提供的讲习班将全州的研究人员介绍到可用的最先进技术。 科学研究核心中的所有设施都将根据需要与生物信息学核心相互作用，以满足阿肯色inbre合作伙伴PUI的需求（请参阅目标，生物信息学核心）。目前，生物医学研究最令人生畏的方面之一是数据管理和生物信息学工具进行分析。对于蛋白质组学研究，确定蛋白质结构的数据收集需要新的信息技术（蛋白质信息学）来分析和解释数据。与生物信息学核心相关的教师将提供用于数据分析的必要专业知识，包括对所有类型的数据的更常规统计分析以及微阵列或蛋白质组学技术生成的数据分析。