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Impact of Infections on the Stability of Established Tolerance

Impact of Infections on the Stability of Established Tolerance
感染对既定耐受稳定性的影响
批准号:
8512661
负责人:
Anita S Chong
金额:
$37.08万
依托单位:
依托单位国家:
美国
项目类别:
财政年份:
2013
资助国家:
美国
项目状态:
已结题
起止时间:
2013-07-01 至 2017-06-30

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中文摘要
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英文摘要
Critical issues emerging from current attempts at inducing transplantation tolerance in the clinic include the need for biomarkers that predict and diagnose tolerance as well as for the identification of barriers to tolerance induction and maintenance. Our preliminary observations have led us to the realization that the durability of the tolerant state is variable and can be unpredictably breached by Listeria infections. The overall goal of the proposed studies Is to determine a mechanistic basis for how Infections can either erode or transiently abrogate robust tolerance after It has been stably established.
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Intrarenal B cells in acute kidney allograft rejection
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  • 项目类别:
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  • 财政年份:
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Intrarenal B cells in acute kidney allograft rejection
  • 批准号:
    10329990
  • 项目类别:
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  • 财政年份:
    2020
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Deconstructing B cell transplantation tolerance
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海外基金