Center for Transdisciplinary ELSI Research in Translational Genomics

ELSI 转化基因组学跨学科研究中心

• 批准号: 8513527
• 负责人: Barbara A. Koenig
• 金额: $ 26.55万
• 依托单位: KAISER FOUNDATION RESEARCH INSTITUTE
• 依托单位国家: 美国
• 财政年份: 2013
• 资助国家: 美国
• 起止时间: 2013-06-16 至 2016-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8513527
• 关键词: Address; Adult; Advisory Committees; Affect; Aging; California; Clinical; Clinical Medicine; Clinical Research; Collaborations; Collection; Communities; Community Outreach; Computerized Medical Record; Conflict (Psychology); DNA; Data; Databases; Development; Discipline; Discipline of Nursing; Disease; Education; Ensure; Environment; Environmental Risk Factor; Epidemiologic Studies; Ethnic Origin; Faculty; Failure; Fellowship; Fellowship Program; Focus Groups; Fostering; Funding; Gender; Gender Role; Genes; Genetic; Genetic Counseling; Genetic Translation; Genome; Genomics; Geographic Information Systems; Goals; Harvest; Health; Health Policy; Health Surveys; Health system; Human Genome; Incidental Findings; Individual; Informed Consent; Integrated Delivery of Health Care; Intervention; Joints; Laws; Learning; Legal; Length; Link; Maps; Measures; Medicine; Modeling; Outcome; Participant; Patients; Pharmacy facility; Pilot Projects; Policies; Policy Analysis; Prevention; Public Health; Race; Research; Research Design; Research Subjects; Research Training; Resources; Sampling; San Francisco; Science Policy; Scientist; Series; Social Policies; Societies; Structure; Students; System; Testing; Training; Translating; Translational Research; Translations; Uncertainty; Underrepresented Minority; Universities; Voice; Woman; Work; base; biobank; clinical application; clinical care; clinically significant; cohort; college; design; doctoral student; ethical legal social implication; genetic epidemiology; genetic variant; genome analysis; genome-wide; health disparity; human subject protection; improved; interdisciplinary collaboration; medical specialties; men; novel; pre-doctoral; programs; public health relevance; research clinical testing; research in practice; sex; social; symposium; telomere; web site; working group

DESCRIPTION (provided by applicant): Harvesting the benefits of genomics requires a new kind of transdisciplinary cooperation. Over the next three years, we will create the Center for Transdisciplinary ELSl Research in Translational Genomics (CT2G) to address key ELSl questions in translational research. The proposed Center brings together the unique resources of Kaiser Permanente Northern California (KPNC), including its Division of Research, and the University of California, San Francisco (UCSF), including the Hastings College of the Law Consortium on Law, Science & Health Policy. A key CT2G resource for training, research, deliberation, and policy analysis is the Kaiser Permanente "Research Program on Genes, Environment, and Health" (RPGEH), designed to foster epidemiological studies. The RPGEH links together participants' data from electronic medical records, biospecimens, health surveys and geographic information systems. The RPGEH includes genome-wide genetic data and measures of telomere length from a sample of over 110,000 men and women, who constitute the Genetic Epidemiology Research in Adult Health and Aging (GERA) cohort. Deepening the existing collaborations between scientists and clinicians at KPNC and UCSF, and utilizing the unique structure of KPNC's integrated health care delivery system, we aim to: 1) Create CT2G and nurture its development as a novel resource for ELSl research in translational genomics. * Implement a management plan and form a Steering Committee and External Advisory Panel * Develop a strong intellectual community through a website, seminar series, and annual conferences * Fund small pilot projects to elucidate barriers to effective genomics translation 2) Convene joint KPNC/UCSF working groups to address critical issues in translational genomics. Focusing on projects with tangible outcomes, we will bring together scholars who have not yet collaborated, creating a blueprint for long-term transdisciplinary work that joins empirical and normative approaches. 3) Plan and initiate a program in ELSl education focused on pre-doctoral students and clinicians. * To expand the pool of under-represented minority ELSl scholars, we will plan and gain approval for a pre-doctoral fellowship program for students from a range of disciplines. * To enhance transdisciplinary collaboration, we will develop a one year ELSl fellowship for clinicians from multiple fields, including nursing, pharmacy, genetic counseling, and clinical medicine.

描述（由申请人提供）：获得基因组学的好处需要一种新型的跨学科合作。在接下来的三年中，我们将创建转化基因组学跨学科 ELSl 研究中心 (CT2G)，以解决转化研究中的关键 ELSl 问题。拟议的中心汇集了北加州凯撒医疗机构 (KPNC)（包括其研究部）和加州大学旧金山分校 (UCSF)（包括法律、科学与健康政策法律联盟黑斯廷斯学院）的独特资源。用于培训、研究、审议和政策分析的关键 CT2G 资源是 Kaiser Permanente“基因、环境和健康研究计划”(RPGEH)，旨在促进流行病学研究。 RPGEH 将参与者来自电子病历、生物样本、健康调查和地理信息系统的数据连接在一起。 RPGEH 包括来自超过 110,000 名男性和女性样本的全基因组遗传数据和端粒长度测量，这些样本构成了成人健康和衰老遗传流行病学研究 (GERA) 队列。 深化 KPNC 和 UCSF 科学家和临床医生之间的现有合作，并利用 KPNC 综合医疗保健服务系统的独特结构，我们的目标是： 1) 创建 CT2G 并培育其发展，作为转化基因组学 ELSl 研究的新资源。 * 实施管理计划并组建指导委员会和外部顾问小组 * 通过网站、研讨会系列和年度会议发展强大的知识社区 * 资助小型试点项目，以阐明有效基因组学翻译的障碍 2) 召集 KPNC/UCSF 联合工作组来解决转化基因组学中的关键问题。 我们将重点关注具有切实成果的项目，将尚未合作的学者聚集在一起，为结合经验和规范方法的长期跨学科工作制定蓝图。 3) 规划并启动一个以博士前学生和临床医生为重点的 ELSl 教育项目。 * 为了扩大代表性不足的少数族裔 ELSl 学者的数量，我们将为来自不同学科的学生规划并获得批准博士前奖学金计划。 * 为了加强跨学科合作，我们将为多个领域的临床医生提供为期一年的 ELSl 奖学金，包括护理、药学、遗传咨询和临床医学。