Center for Transdisciplinary ELSI Research in Translational Genomics

ELSI 转化基因组学跨学科研究中心

• 批准号: 8682892
• 负责人: Barbara A. Koenig
• 金额: $ 25.38万
• 依托单位: KAISER FOUNDATION RESEARCH INSTITUTE
• 依托单位国家: 美国
• 财政年份: 2013
• 资助国家: 美国
• 起止时间: 2013-06-16 至 2016-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8682892
• 关键词: Address; Adult; Advisory Committees; Affect; Aging; California; Clinical; Clinical Medicine; Clinical Research; Collaborations; Collection; Communities; Community Outreach; Computerized Medical Record; Conflict (Psychology); DNA; Data; Databases; Development; Discipline; Discipline of Nursing; Disease; Education; Ensure; Environment; Environmental Risk Factor; Epidemiologic Studies; Ethnic Origin; Faculty; Failure; Fellowship; Fellowship Program; Focus Groups; Fostering; Funding; Gender; Gender Role; Genes; Genetic; Genetic Counseling; Genetic Translation; Genome; Genomics; Geographic Information Systems; Goals; Harvest; Health; Health Policy; Health Surveys; Health system; Human Genome; Incidental Findings; Individual; Informed Consent; Integrated Delivery of Health Care; Intervention; Joints; Laws; Learning; Legal; Length; Link; Maps; Measures; Medicine; Modeling; Outcome; Participant; Patients; Pharmacy facility; Pilot Projects; Policies; Policy Analysis; Prevention; Public Health; Race; Research; Research Design; Research Subjects; Research Training; Resources; Sampling; San Francisco; Science Policy; Scientist; Series; Social Policies; Societies; Structure; Students; System; Testing; Training; Translating; Translational Research; Translations; Uncertainty; Underrepresented Minority; Universities; Voice; Woman; Work; base; biobank; clinical application; clinical care; clinically significant; cohort; college; design; doctoral student; ethical legal social implication; genetic epidemiology; genetic variant; genome analysis; genome-wide; health disparity; human subject protection; improved; interdisciplinary collaboration; medical specialties; men; novel; pre-doctoral; programs; public health relevance; research clinical testing; research in practice; sex; social; symposium; telomere; web site; working group

DESCRIPTION (provided by applicant): Harvesting the benefits of genomics requires a new kind of transdisciplinary cooperation. Over the next three years, we will create the Center for Transdisciplinary ELSl Research in Translational Genomics (CT2G) to address key ELSl questions in translational research. The proposed Center brings together the unique resources of Kaiser Permanente Northern California (KPNC), including its Division of Research, and the University of California, San Francisco (UCSF), including the Hastings College of the Law Consortium on Law, Science & Health Policy. A key CT2G resource for training, research, deliberation, and policy analysis is the Kaiser Permanente "Research Program on Genes, Environment, and Health" (RPGEH), designed to foster epidemiological studies. The RPGEH links together participants' data from electronic medical records, biospecimens, health surveys and geographic information systems. The RPGEH includes genome-wide genetic data and measures of telomere length from a sample of over 110,000 men and women, who constitute the Genetic Epidemiology Research in Adult Health and Aging (GERA) cohort. Deepening the existing collaborations between scientists and clinicians at KPNC and UCSF, and utilizing the unique structure of KPNC's integrated health care delivery system, we aim to: 1) Create CT2G and nurture its development as a novel resource for ELSl research in translational genomics. * Implement a management plan and form a Steering Committee and External Advisory Panel * Develop a strong intellectual community through a website, seminar series, and annual conferences * Fund small pilot projects to elucidate barriers to effective genomics translation 2) Convene joint KPNC/UCSF working groups to address critical issues in translational genomics. Focusing on projects with tangible outcomes, we will bring together scholars who have not yet collaborated, creating a blueprint for long-term transdisciplinary work that joins empirical and normative approaches. 3) Plan and initiate a program in ELSl education focused on pre-doctoral students and clinicians. * To expand the pool of under-represented minority ELSl scholars, we will plan and gain approval for a pre-doctoral fellowship program for students from a range of disciplines. * To enhance transdisciplinary collaboration, we will develop a one year ELSl fellowship for clinicians from multiple fields, including nursing, pharmacy, genetic counseling, and clinical medicine.

描述（由申请人提供）：收获基因组学的好处需要一种新的跨学科合作。在未来三年内，我们将创建转化基因组学跨学科ELSl研究中心（CT2G），以解决转化研究中的关键ELSl问题。拟议中的中心汇集了北加州凯撒医疗机构（KPNC）的独特资源，包括其研究部，以及加州大学旧金山分校（UCSF），包括黑斯廷斯法律学院法律、科学与卫生政策联盟。用于培训、研究、审议和政策分析的关键CT2G资源是Kaiser Permanente“基因、环境和健康研究计划”（RPGEH），旨在促进流行病学研究。RPGEH将来自电子医疗记录、生物标本、健康调查和地理信息系统的参与者数据联系在一起。RPGEH包括来自11万多名男性和女性样本的全基因组遗传数据和端粒长度测量，这些人构成了成人健康和老龄化遗传流行病学研究（GERA）队列。深化KPNC和UCSF的科学家和临床医生之间的现有合作，并利用KPNC综合医疗服务系统的独特结构，我们的目标是：