Novel Ultra-Flexible Hybrid Circuits for Intraocular Retinal Prostheses

用于眼内视网膜假体的新型超灵活混合电路

• 批准号: 8592776
• 负责人: JAMES D. WEILAND
• 金额: $ 68.35万
• 依托单位: PREMITEC, INC.
• 依托单位国家: 美国
• 财政年份: 2007
• 资助国家: 美国
• 起止时间: 2007-09-30 至 2015-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8592776
• 关键词: Address; Age related macular degeneration; Animal Model; Area; Biocompatible; Biological; Businesses; Bypass; California; Characteristics; Clinical; Collaborations; Corrosives; Coupled; Custom; Data; Development; Device Safety; Devices; Diamond; Disease; Electrodes; Electronics; Encapsulated; Evaluation; Eye; Film; Functional disorder; Goals; Health; Hybrids; Implant; Implantation procedure; In Vitro; Individual; Institutes; Isotonic Exercise; Lead; Letters; Liquid substance; Los Angeles; Medical Device; Microelectrodes; Microfabrication; Miniature Swine; Nervous system structure; Neurosurgeon; Patients; Peripheral Nervous System; Phase; Photoreceptors; Polymers; Population; Positioning Attribute; Principal Investigator; Process; Prosthesis; Public Health; Reading; Research; Resolution; Retina; Retinal; Retinitis Pigmentosa; Saline; Scheme; Secure; Silicon; Simulate; Site; Solutions; Structure; Surface; Surgical incisions; System; Technology; Technology Transfer; Telemetry; Testing; Thick; Universities; Vial device; Vision; Visual Acuity; Visual Pathways; Widespread Disease; Wireless Technology; Work; base; commercialization; density; design; experience; flexibility; implantation; improved; in vivo; miniaturize; nervous system disorder; neural prosthesis; neural stimulation; novel; public health relevance; relating to nervous system; retinal prosthesis; sample fixation; scaffold; success; tool; voltage

Abstract Retinal prosthetic devices currently under development are designed to bypass the non-functioning portion of the visual pathway (photoreceptor layer) in individuals suffering from diseases including retinitis pigmentosa (RP) and age-related macular degeneration (AMD). Current devices enable patients to only see object positions and read large letters, and further technical advancements are required for improved vision and device safety. These advancements include high resolution neural interfacing, fully intraocular implantation, tack-free fixation of the electrodes in close proximity to the retina, and ultra-flexible, reliable packaging. This project will address each or these needs. This Small Business Technology Transfer Phase II project proposes development of Novel Ultra-Flexible Hybrid Circuits for Intraocular Retinal Prostheses. In these flexible retinal implants, ultra-thin silicon integrated circuits (IC's) will be electrically connected to a flexible electrode array and thin-film antenna coil, then fully encapsulated between multiple layers of polymers resulting in a monolithic implantable neural interface. This implantable neural interface will consist of a microstimulator IC, an electrode array, a RF antenna, and high density connections between components. The polymer layers will serve not only as the device substrate but also as protection for the components from the corrosive effects of the biological fluids. The device will be pre-formed following the curvature of the eye and coupled with a superstructure so as to be under slight compression after implantation in the eye, helping to hold it secure and stabilize the electrodes against the surface of the retina This will lead to a device with better visual acuity and to a safer retinal prosthesis without the use o a retinal tack and the need of a cable penetrating the eye wall.

摘要 目前正在开发的视网膜假体装置被设计成绕过视网膜。 个体视觉通路的无功能部分（感光层） 患有视网膜色素变性（RP）和年龄相关性黄斑病变等疾病 退行性变（AMD）。目前的设备使患者只能看到物体的位置， 阅读大字母，需要进一步的技术进步来改善视力 和设备安全性。这些进步包括高分辨率神经接口， 眼内植入，将电极无粘性固定在靠近 视网膜和超灵活、可靠的包装。该项目将解决每一个或这些 需求 小企业技术转让第二阶段项目建议开发 用于眼内视网膜假体的新型超柔性混合电路。在这些灵活的 视网膜植入物，超薄硅集成电路（IC）将电连接到 柔性电极阵列和薄膜天线线圈，然后完全封装在 多层聚合物，从而形成单片可植入神经界面。这 植入式神经接口将由微刺激器IC、电极阵列、RF 天线和组件之间的高密度连接。聚合物层将 不仅用作器件衬底，而且还用作保护元件免受 生物体液的腐蚀性器械将在以下步骤中预成型： 眼睛的曲率，并与上层建筑相结合，以便在轻微的 植入眼内后的压缩，有助于固定眼并稳定眼 电极贴在视网膜表面 这将导致一种具有更好视力的装置和一种更安全的视网膜假体 而不需要使用视网膜钉和穿透眼球壁的线缆。