Circadian Rhythms and Sleep-Wake Cycles in Parkinson's Disease

帕金森病的昼夜节律和睡眠-觉醒周期

基本信息

项目摘要

DESCRIPTION (provided by applicant): Disruption of sleep and alertness is one of the most disabling non-motor symptoms of Parkinson's disease (PD). Mechanisms leading to impaired sleep and alertness in PD are not well understood, and treatment options remain limited. This application for a K23 Mentored Patient-Oriented Research Career Development Award entitled "Circadian rhythms and sleep-wake cycles in Parkinson's Disease" is designed to provide Dr. Aleksandar Videnovic with the research skills and experience to bridge the areas of movement disorders, sleep and circadian biology in order to understand the basis for sleep and wake disturbances in PD. Dr. Videnovic is an Assistant Professor of Neurology at Northwestern University in Chicago. He completed residency training in Neurology at Northwestern University, a clinical fellowship in Movement Disorders at Rush University, and obtained a master's degree in clinical research from Rush Graduate College. Dr. Videnovic's long term career goal is to understand the role of circadian rhythms and sleep on neurological outcomes in movement disorders, and to utilize this knowledge to improve patients' health and quality of life by innovative circadian and sleep based strategies. His immediate goals are to gain knowledge and skills in circadian biology, sleep medicine, and clinical research methodology so as to investigate potential circadian rhythm abnormalities in PD. Dr. Videnovic has assembled a team of researchers who will mentor him during this award. His primary mentor, Dr. Phyllis Zee, and co-mentor Dr. Fred Turek are renowned investigators in the field of circadian biology with complementary expertise in patient oriented and basic science research. Expertise in mathematical modeling of circadian rhythms, statistical analyses, and clinical research in PD, will be provided by consultants, Drs. Elizabeth Klerman, Alfred Rademaker, and Tanya Simuni. The proposed training plan encompasses didactic and hands-on training on the characterization of the circadian system using physiological and molecular markers, assessments of the sleep-wake cycle, applications of circadian based treatments including light therapy, and further training in clinical research methods. The first part of the proposed research will examine the amplitude and stability of the circadian system using biological markers of the circadian system (e.g., melatonin, clock genes and the rest-activity cycle). The primary hypothesis is that disruption of circadian rhythmicity plays an important role in the development of poor sleep quality and daytime somnolence in PD. These markers of circadian rhythmicity will be correlated with sleep quality and degree of daytime somnolence in PD participants and healthy controls. The second part of the project is to test the hypothesis that increasing the strength and stability of circadian rhythms, using bright light exposure, will improve sleep quality and daytime somnolence in PD. Results from this research and the proposed training plan will form the foundation for an independent clinical research program at the interface of sleep, circadian biology and PD which may lead to novel and more effective treatments aimed to improve the health and quality of life of patients with PD. PUBLIC HEALTH RELEVANCE: Sleep dysfunction and excessive daytime somnolence are common and poorly understood symptoms of Parkinson 's disease (PD), affecting both patients and caregivers, and have a negative impact on the quality of life, safety, morbidity and mortality in the PD population. The proposed research is designed to provide new insight into a potential circadian rhythm etiology of sleep dysfunction in PD, form the foundation for novel circadian-based treatment strategies, and provide mentored training for the candidate as he continues to develop his career in patient-oriented research.
描述(申请人提供):睡眠和警觉中断是帕金森氏病(PD)最严重的非运动症状之一。导致帕金森病患者睡眠和警觉性受损的机制尚不清楚,治疗选择仍然有限。本申请表旨在为亚历山大·维德诺维奇博士提供研究技能和经验,将运动障碍、睡眠和昼夜生物学联系起来,以了解帕金森氏病睡眠和觉醒障碍的基础。维德诺维奇博士是芝加哥西北大学的神经学助理教授。他在西北大学完成了神经学住院医师培训,在拉什大学获得了运动障碍临床研究员资格,并在拉什研究生院获得了临床研究硕士学位。维德诺维奇博士的长期职业目标是了解昼夜节律和睡眠在运动障碍中对神经结果的作用,并利用这一知识通过基于昼夜节律和睡眠的创新策略来改善患者的健康和生活质量。他的近期目标是获得昼夜生物学、睡眠医学和临床研究方法方面的知识和技能,以调查帕金森病患者潜在的昼夜节律异常。维德诺维奇博士已经组建了一个研究团队,他们将在颁奖期间指导他。他的主要导师Phyllis Zee博士和共同导师Fred Turek博士都是昼夜生物学领域的知名研究人员,在以患者为中心的基础科学研究方面具有互补的专业知识。在昼夜节律的数学建模、统计分析和帕金森病临床研究方面的专业知识将由顾问伊丽莎白·克勒曼博士、阿尔弗雷德·拉德梅克博士和坦尼娅·西穆尼提供。拟议的培训计划包括使用生理和分子标记表征昼夜节律系统的授课和动手培训,对睡眠-觉醒周期的评估,包括光疗在内的基于昼夜节律的治疗的应用,以及临床研究方法的进一步培训。拟议研究的第一部分将使用昼夜节律系统的生物标记物(例如褪黑素、时钟基因和静息-活动周期)来检查昼夜节律系统的幅度和稳定性。基本假设是昼夜节律的紊乱在帕金森病患者睡眠质量差和日间嗜睡的发展中起着重要作用。这些昼夜节律性的标记物将与PD参与者和健康对照组的睡眠质量和白天嗜睡程度相关。项目的第二部分是检验增加强度和稳定性的假设 使用强光照射,改变昼夜节律,将改善帕金森病患者的睡眠质量和白天嗜睡。这项研究的结果和拟议的培训计划将为睡眠、昼夜生物学和帕金森病之间的独立临床研究计划奠定基础,该计划可能导致旨在改善帕金森病患者健康和生活质量的新的、更有效的治疗方法。 公共卫生相关性:睡眠障碍和日间过度嗜睡是帕金森S病(PD)常见且知之甚少的症状,影响患者和照顾者,并对PD人群的生活质量、安全性、发病率和死亡率产生负面影响。拟议的研究旨在为PD患者睡眠障碍的潜在昼夜节律病因提供新的见解,为新的基于昼夜节律的治疗策略奠定基础,并为候选人在继续以患者为导向的研究中发展其职业生涯提供指导培训。

项目成果

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Aleksandar Videnovic其他文献

Aleksandar Videnovic的其他文献

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{{ truncateString('Aleksandar Videnovic', 18)}}的其他基金

Retinal Determinants of Circadian Function and Sleep-Wake Cycles in Parkinson's Disease
帕金森病昼夜节律功能和睡眠-觉醒周期的视网膜决定因素
  • 批准号:
    10735341
  • 财政年份:
    2023
  • 资助金额:
    $ 16.93万
  • 项目类别:
NAPS2 Recruitment, Education, and Outreach Core
NAPS2 招聘、教育和外展核心
  • 批准号:
    10457864
  • 财政年份:
    2021
  • 资助金额:
    $ 16.93万
  • 项目类别:
NAPS2 Recruitment, Education, and Outreach Core
NAPS2 招聘、教育和外展核心
  • 批准号:
    10187090
  • 财政年份:
    2021
  • 资助金额:
    $ 16.93万
  • 项目类别:
NAPS2 Recruitment, Education, and Outreach Core
NAPS2 招聘、教育和外展核心
  • 批准号:
    10674058
  • 财政年份:
    2021
  • 资助金额:
    $ 16.93万
  • 项目类别:
A Dose Selection Trial of Light Therapy for Impaired Sleep in Parkinson's Disease
光疗法治疗帕金森病睡眠障碍的剂量选择试验
  • 批准号:
    10012951
  • 财政年份:
    2019
  • 资助金额:
    $ 16.93万
  • 项目类别:
A Dose Selection Trial of Light Therapy for Impaired Sleep in Parkinson's Disease
光疗法治疗帕金森病睡眠障碍的剂量选择试验
  • 批准号:
    10208984
  • 财政年份:
    2019
  • 资助金额:
    $ 16.93万
  • 项目类别:
Bright light modulation of non-motor symptoms in Parkinson's disease
帕金森病非运动症状的亮光调节
  • 批准号:
    10054198
  • 财政年份:
    2016
  • 资助金额:
    $ 16.93万
  • 项目类别:
Circadian Rhythms and Sleep-Wake Cycles in Parkinson's Disease
帕金森病的昼夜节律和睡眠-觉醒周期
  • 批准号:
    9068250
  • 财政年份:
    2012
  • 资助金额:
    $ 16.93万
  • 项目类别:
Circadian Rhythms and Sleep-Wake Cycles in Parkinson's Disease
帕金森病的昼夜节律和睡眠-觉醒周期
  • 批准号:
    8664946
  • 财政年份:
    2012
  • 资助金额:
    $ 16.93万
  • 项目类别:
Circadian Rhythms and Sleep-Wake Cycles in Parkinson's Disease
帕金森病的昼夜节律和睡眠-觉醒周期
  • 批准号:
    8460038
  • 财政年份:
    2012
  • 资助金额:
    $ 16.93万
  • 项目类别:

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24 小时活动周期在保护认知功能和预防阿尔茨海默病及相关痴呆方面的作用
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