24-hour Activity Cycles to Optimize Cognitive Resilience to Alzheimer's Disease in African Americans: The Jackson Heart Study

24 小时活动周期可优化非裔美国人对阿尔茨海默病的认知能力:杰克逊心脏研究

基本信息

项目摘要

ABSTRACT Alzheimer’s Disease and Related Dementias (ADRD) is an emerging epidemic in the United States; Black adults are particularly vulnerable. Without effective prevention strategies to target and optimize resilience to ADRD, 14 million U.S. adults will be living with ADRD by 2060, with an associated financial burden of $511 billion by 2040. While physical activity has been consistently identified as a modifiable, protective factor to prevent cognitive decline and delay age of dementia onset, the majority of this evidence is based on reported estimates of leisure-time moderate to vigorous intensity physical activity (MVPA), which provides an incomplete characterization of this complex behavioral phenotype. Adults spend approximately 95% of waking hours sedentary or in light intensity physical activity; however, there is limited research exploring the interrelations of these different intensity categories. Further, less than 10% of adults accumulate sufficient MVPA to meet recommendations, and this prevalence estimate is even lower in Black adults. Studies have also demonstrated that sleep disturbances, including short sleep duration, circadian rhythm disturbances, and sleep-disordered breathing may increase risk of cognitive impairment. However, this evidence is still emerging. Further, Black adults have a higher prevalence of disordered sleep compared to Whites. Despite the potential importance of both waking and sleep behaviors to optimize cognitive resilience, their impacts are often studied in isolation. To address these critical research gaps, we propose the Jackson Heart Study (JHS) 24-Hour Activity Cycle Study (Jackson 24H-ACT), a four-year ancillary study to the funded JHS Exam 4 (2020-22). The overall goal of the Jackson 24H-ACT Study is to quantify 24-hour activity cycle behaviors and estimate the independent and joint roles of waking (sedentary to vigorous intensity physical activity) and sleep (duration and quality characteristics) behaviors to optimize cognitive resilience. All participants attending Exam 4 and who are willing to concurrently wear an accelerometer and sleep actigraphy watch for seven consecutive days will be invited to participate. Exclusion criteria include: unable to ambulate or physician instruction not to be physically active. Jackson 24H-ACT ancillary study measures include: (1) accelerometry and (2) sleep actigraphy, which complement extant JHS data, and data that will be collected as part of Exam 4. To accomplish these goals, we propose to examine the independent and joint associations of 24-hour activity cycle behaviors with: (Aim 1) cognitive functioning; (Aim 2) subclinical markers of cerebrovascular disease (e.g. white matter hyperintensity volumes), white matter microstructural integrity, and neurodegeneration (e.g. hippocampal and total brain volumes) quantified from brain magnetic resonance (MRI) imaging; and (Aim 3) the prevalence of mild cognitive impairment (MCI) and dementia. Potential moderation by sex, age epoch (<65 versus ≥65 years), education/literacy, and APOE ɛ4 genotype will also be evaluated. Jackson 24H-ACT will provide novel information on the role of 24-hour activity cycles in promoting cognitive resilience in Black adults.
摘要

项目成果

期刊论文数量(0)
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Kelley Pettee Gabriel其他文献

Multimorbidity Trajectories From Early to Middle Adulthood and Physical Activity
从成年早期到中期的多病轨迹与身体活动
  • DOI:
    10.1016/j.amepre.2024.11.003
  • 发表时间:
    2025-03-01
  • 期刊:
  • 影响因子:
    4.500
  • 作者:
    Erin E. Dooley;C. Barrett Bowling;Bjoern Hornikel;Baojiang Chen;Sylvia E. Badon;Cora E. Lewis;Kelley Pettee Gabriel
  • 通讯作者:
    Kelley Pettee Gabriel
Dynamic Functional Variable Selection for Multimodal mHealth Data
多模态 mHealth 数据的动态功能变量选择
  • DOI:
  • 发表时间:
    2024
  • 期刊:
  • 影响因子:
    4.4
  • 作者:
    Matthew D. Koslovsky;Kelley Pettee Gabriel;Michael Businelle;David W. Wetter;Darla E. Kendzor
  • 通讯作者:
    Darla E. Kendzor
Gender diversity and daily steps: Findings from the Adolescent Brain Cognitive Development Study
  • DOI:
    10.1016/j.annepidem.2024.11.004
  • 发表时间:
    2025-01-01
  • 期刊:
  • 影响因子:
  • 作者:
    Jason M. Nagata;Shirley Sui;Angela E. Kim;Iris Yuefan Shao;Christopher D. Otmar;Kyle T. Ganson;Alexander Testa;Erin E. Dooley;Holly C. Gooding;Fiona C. Baker;Kelley Pettee Gabriel
  • 通讯作者:
    Kelley Pettee Gabriel
Association Between Polypharmacy and Physical Function in Middle-aged Adults: Findings from the CARDIA Function Study
  • DOI:
    10.1007/s11606-025-09692-3
  • 发表时间:
    2025-07-07
  • 期刊:
  • 影响因子:
    4.200
  • 作者:
    Caroline E. Sloan;Marissa C. Ashner;Cara L. McDermott;Brett T. Burrows;Carl Pieper;Ankeet S. Bhatt;Kelley Pettee Gabriel;C. Barrett Bowling
  • 通讯作者:
    C. Barrett Bowling
73. Disentangling School and Neighborhood Effects on Screen Time Among Adolescents in the United States
  • DOI:
    10.1016/j.jadohealth.2020.12.082
  • 发表时间:
    2021-02-01
  • 期刊:
  • 影响因子:
  • 作者:
    Hoda S. Abdel Magid;Carly E. Milliren;Kelley Pettee Gabriel;Jason Nagata
  • 通讯作者:
    Jason Nagata

Kelley Pettee Gabriel的其他文献

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{{ truncateString('Kelley Pettee Gabriel', 18)}}的其他基金

24-hour Activity Cycles to Optimize Cognitive Resilience to Alzheimer's Disease in African Americans: The Jackson Heart Study
24 小时活动周期可优化非裔美国人对阿尔茨海默病的认知能力:杰克逊心脏研究
  • 批准号:
    10619020
  • 财政年份:
    2020
  • 资助金额:
    $ 96万
  • 项目类别:
24-hour Activity Cycles to Optimize Cognitive Resilience to Alzheimer's Disease in African Americans: The Jackson Heart Study
24 小时活动周期可优化非裔美国人对阿尔茨海默病的认知能力:杰克逊心脏研究
  • 批准号:
    10261464
  • 财政年份:
    2020
  • 资助金额:
    $ 96万
  • 项目类别:
Young Adult and Midlife Transitions in Physical Activity and Sedentary Behavior with Heart Failure Risk and Progression: Coronary Artery Risk Development in Young Adults (CARDIA)
年轻人和中年体力活动和久坐行为的转变与心力衰竭风险和进展:年轻人冠状动脉风险发展(CARDIA)
  • 批准号:
    10457985
  • 财政年份:
    2020
  • 资助金额:
    $ 96万
  • 项目类别:
Young Adult and Midlife Transitions in Physical Activity and Sedentary Behavior with Heart Failure Risk and Progression: Coronary Artery Risk Development in Young Adults (CARDIA)
年轻人和中年体力活动和久坐行为的转变与心力衰竭风险和进展:年轻人冠状动脉风险发展(CARDIA)
  • 批准号:
    10687120
  • 财政年份:
    2020
  • 资助金额:
    $ 96万
  • 项目类别:
Young Adult and Midlife Transitions in Physical Activity and Sedentary Behavior with Heart Failure Risk and Progression: Coronary Artery Risk Development in Young Adults (CARDIA)
年轻人和中年体力活动和久坐行为的转变与心力衰竭风险和进展:年轻人冠状动脉风险发展(CARDIA)
  • 批准号:
    10224323
  • 财政年份:
    2020
  • 资助金额:
    $ 96万
  • 项目类别:
The Associations of Mid- and Late-Life Physical Activity on Falls in a Large Prospective Study of Older Adults
一项针对老年人的大型前瞻性研究显示中年和晚年体力活动与跌倒的关系
  • 批准号:
    9145299
  • 财政年份:
    2015
  • 资助金额:
    $ 96万
  • 项目类别:
10-Year Changes in Objectively-Measured Physical Activity and Sedentary Behavior in the CARDIA Cohort
CARDIA 队列中客观测量的体力活动和久坐行为的 10 年变化
  • 批准号:
    9130387
  • 财政年份:
    2015
  • 资助金额:
    $ 96万
  • 项目类别:

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The role of 24-hour activity cycles in preserving cognitive function and preventing Alzheimer's disease and related dementias
24 小时活动周期在保护认知功能和预防阿尔茨海默病及相关痴呆方面的作用
  • 批准号:
    10455800
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    2022
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    $ 96万
  • 项目类别:
24-hour Activity Cycles to Optimize Cognitive Resilience to Alzheimer's Disease in African Americans: The Jackson Heart Study
24 小时活动周期可优化非裔美国人对阿尔茨海默病的认知能力:杰克逊心脏研究
  • 批准号:
    10619020
  • 财政年份:
    2020
  • 资助金额:
    $ 96万
  • 项目类别:
24-hour Activity Cycles to Optimize Cognitive Resilience to Alzheimer's Disease in African Americans: The Jackson Heart Study
24 小时活动周期可优化非裔美国人对阿尔茨海默病的认知能力:杰克逊心脏研究
  • 批准号:
    10261464
  • 财政年份:
    2020
  • 资助金额:
    $ 96万
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Magnetic Evolution of Sun-like Activity Cycles
类太阳活动周期的磁演化
  • 批准号:
    1812634
  • 财政年份:
    2018
  • 资助金额:
    $ 96万
  • 项目类别:
    Continuing Grant
Stellar and Solar Magnetic Activity Cycles
恒星和太阳磁活动周期
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    0742144
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    2008
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Stellar and Solar Magnetic Activity Cycles
恒星和太阳磁活动周期
  • 批准号:
    0447159
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    2004
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    $ 96万
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    Continuing Grant
Stellar and Solar Magnetic Activity Cycles
恒星和太阳磁活动周期
  • 批准号:
    0103883
  • 财政年份:
    2001
  • 资助金额:
    $ 96万
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    Continuing Grant
Stellar and Solar Magnetic Activity Cycles
恒星和太阳磁活动周期
  • 批准号:
    9731636
  • 财政年份:
    1998
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    $ 96万
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    Continuing Grant
Stellar and Solar Magnetic Activity Cycles
恒星和太阳磁活动周期
  • 批准号:
    9420044
  • 财政年份:
    1995
  • 资助金额:
    $ 96万
  • 项目类别:
    Continuing Grant
Stellar and Solar Magnetic Activity Cycles
恒星和太阳磁活动周期
  • 批准号:
    9114733
  • 财政年份:
    1991
  • 资助金额:
    $ 96万
  • 项目类别:
    Continuing grant
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