2012 Barriers of the CNS Gordon Research Conference & Gordon Research Seminar

2012 CNS 戈登研究会议的障碍

• 批准号: 8319104
• 负责人: Quentin R. Smith
• 金额: $ 1.63万
• 依托单位: GORDON RESEARCH CONFERENCES
• 依托单位国家: 美国
• 财政年份: 2012
• 资助国家: 美国
• 起止时间: 2012-03-15 至 2013-02-28
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8319104
• 关键词: Address; Arachnoid Membrane; Area; Autoimmune Diseases; Blood - brain barrier anatomy; Brain; Brain Diseases; Brain Neoplasms; Central Nervous System Agents; Central Nervous System Diseases; Central Nervous System Infections; Choroid Plexus Epithelium; Country; Development; Disease; Drug Delivery Systems; Environment; Faculty; Feedback; Funding; Future; Goals; Growth; Growth and Development function; Health; Human; Image; International; Knowledge; London; Mentors; Methods; Neuraxis; Neurodegenerative Disorders; New Hampshire; Participant; Pathogenesis; Pathology; Permeability; Pharmaceutical Preparations; Play; Postdoctoral Fellow; Prevention; Process; Productivity; Property; Request for Applications; Request for Proposals; Research; Research Personnel; Role; Scientist; Signal Transduction; Site; Staging; Stroke; Structure; Students; Surveys; System; Therapeutic Agents; Traumatic Brain Injury; Treatment Efficacy; angiogenesis; college; cost; design; drug candidate; graduate student; human disease; improved; interest; lectures; meetings; nervous system disorder; novel strategies; novel therapeutics; prevent; programs; relating to nervous system; symposium

DESCRIPTION (provided by applicant): This proposal requests support for partial funding for the 2012 "Barriers of the Central Nervous System (CNS)" Gordon Research Conference (GRC) and accompanying Gordon Research Seminar (GRS) that will be held at Colby Sawyer College, New Hampshire, on June 16 -17, 2012 (GRS) and June 17 - 22, 2012 (GRC). The overall goal of this international conference is to increase understanding of the basic mechanisms underlying the structure and function of the blood-brain barrier (BBB) systems (i.e., brain vasculature, choroid plexus epithelium, arachnoid membrane) in health and disease and to explore strategies for overcoming these barriers to improve treatment of human disease. One of the major discussion topics covered by this conference is how barrier systems limit therapeutic efficacy for many potentially active CNS drugs by preventing them from reaching active concentrations at their sites of action within the CNS. Disruption of barrier systems also plays critical roles in many CNS disease processes, including stroke, brain tumors, brain trauma, CNS infection, autoimmune disease, and neurodegenerative disease. The specific aim of the "Barriers" GRC is to bring together international experts as well as young investigators, postdocs, and students from across the world with a broad range of interests in barrier issues for a five-day conference focused on cutting edge topics in the barriers field in the isolated setting of Colby Sawyer College. The program will include 2 Keynote Lectures and 8 sessions that address: Barrier Structure and Function, Barrier Permeability and Signaling, Barrier Transporters, Drug Delivery, Barrier Alterations in Disease, Angiogenesis and Brain Tumors, Barrier Imaging, and Other Barrier Systems. The "Barriers" GRC fills a critical niche which otherwise does not exist among other major international and national conferences to bring together barrier scientists from diverse fields and countries for a focused meeting on barrier issues. The "Barriers" GRC will be accompanied by a 2-day (Saturday/Sunday) "Barriers" GRS, organized by junior investigators at the postdoctoral level, which is intended to introduce younger scientists (postgraduate students, post-docs, junior faculty) to the relevant methods and issues of the field and to facilitate networking between junior and more senior researchers. The first GRS on this subject was held in 2010 and was very successful. The importance of this application is highlighted by the fact that this Gordon Conference is one of only 2 international conferences held on this specific topic, in a cycle of alternating years. The application has significant relationship to health, in that the presentations and discussions will help to define te role of the barriers in the development and progression of CNS diseases and will identify novel strategies to overcome barrier systems to improve treatment and prevention of neural disorders. PUBLIC HEALTH RELEVANCE: The "Barriers of the CNS" Gordon Research Conference and accompanying Research Seminar will help scientists from across the world to better understand the function of the brain barrier systems in health and disease, and, through this knowledge, to develop improved strategies to overcome the barriers for the treatment of human CNS diseases. It is estimated that >98% of potential drug candidates for treatment of brain diseases are prevented from reaching the brain by the restrictive transport properties of the blood-brain barrier. This conference will allow scientists to challenge established dogmas in focused discussions, explore new areas of future promise or need, and to mentor new scientists in the field for future development.

描述（由申请人提供）：本提案要求支持2012年“中枢神经系统障碍”戈登研究会议（GRC）和相应的戈登研究研讨会（GRS），该会议将于2012年6月16日至17日（GRS）和2012年6月17日至22日（GRC）在新罕布什尔州科尔比索耶学院举行。本次国际会议的总体目标是增加对血脑屏障（BBB）系统（即脑血管系统、脉络膜丛上皮、蛛网膜）结构和功能的基本机制的理解，并探讨克服这些障碍以改善人类疾病治疗的策略。本次会议的主要讨论主题之一是屏障系统如何通过阻止药物在中枢神经系统内的作用部位达到有效浓度来限制许多潜在活性中枢神经系统药物的治疗效果。屏障系统的破坏在许多中枢神经系统疾病过程中也起着关键作用，包括中风、脑肿瘤、脑外伤、中枢神经系统感染、自身免疫性疾病和神经退行性疾病。“障碍”GRC的具体目标是汇集国际专家以及来自世界各地的年轻研究人员、博士后和学生，他们对障碍问题有广泛的兴趣，在Colby Sawyer学院的孤立环境中举行为期五天的会议，重点讨论障碍领域的前沿话题。该计划将包括2个主题演讲和8个会议，涉及：屏障结构和功能，屏障通透性和信号传导，屏障转运蛋白，药物输送，疾病中的屏障改变，血管生成和脑肿瘤，屏障成像和其他屏障系统。“屏障”GRC填补了一个关键的利基，否则在其他主要的国际和国家会议中不存在，将来自不同领域和国家的屏障科学家聚集在一起，集中讨论屏障问题。“壁垒”GRC将与为期2天（周六/周日）的“壁垒”GRS一起进行，由博士后级别的初级研究人员组织，旨在向年轻科学家（研究生、博士后、初级教师）介绍该领域的相关方法和问题，并促进初级和高级研究人员之间的交流。2010年举行了关于这一主题的第一次GRS会议，非常成功。这一应用的重要性突出了这样一个事实，即戈登会议是仅有的两个国际会议之一，在交替的周期中举行这一特定主题。该应用与健康有着重要的关系，因为演讲和讨论将有助于确定障碍在中枢神经系统疾病的发展和进展中的作用，并将确定克服障碍系统的新策略，以改善神经系统疾病的治疗和预防。