Influence of reward on memory consolidation in adults and adolescence

奖励对成人和青少年记忆巩固的影响

• 批准号: 9450704
• 负责人: Vishnu Pradeep Murty
• 金额: $ 23.01万
• 依托单位: TEMPLE UNIV OF THE COMMONWEALTH
• 依托单位国家: 美国
• 财政年份: 2019
• 资助国家: 美国
• 起止时间: 2019-06-01 至 2021-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9450704
• 关键词: Adolescence; Adolescent; Adult; Age; Alcohol or Other Drugs use; Animal Model; Animals; Behavior; Behavioral; Categories; Data; Development; Developmental Process; Dopamine; Drug abuse; Drug usage; Electroencephalography; Episodic memory; Esthesia; Event; Foundations; Functional Magnetic Resonance Imaging; Height; Hippocampus (Brain); Hour; Human; Impulsivity; Individual; Intervention; Investigation; Lead; Learning; Literature; Long-Term Potentiation; Measures; Mediating; Memory; Modality; Modeling; Motivation; Napping; Neurobiology; Neurosciences; Participant; Pharmaceutical Preparations; Population; Process; Research; Rewards; Risk; Risk-Taking; Rodent; Rodent Model; Short-Term Memory; Signal Transduction; Sleep; Slow-Wave Sleep; Substance Use Disorder; Substance abuse problem; Support System; System; Techniques; Testing; Time; Translating; Work; behavioral pharmacology; density; dopamine system; drug craving; drug relapse; early adolescence; emerging adult; long term memory; memory consolidation; memory encoding; mesolimbic system; motivated behavior; multimodality; neurobehavioral; neurodevelopment; neuroimaging; neuroregulation; novel; relating to nervous system; sensory cortex; sleep spindle; tool

Project Summary/Abstract Adolescence marks a state of increased engagement of dopamine systems, a neurobiological state associated with increased reward-motivated behaviors. While increased dopamine signaling during this time period predominately supports adaptive developmental processes, such as exploration and reward learning, it can also propel risk taking behaviors associated with substance use and abuse. Prominent animal models have shown that engagement of dopamine systems and increased reward sensitivtycan increase plasticity and consolidation in hippocampal learning systems, resulting in enhanced memory for rewarding events. Critically, these enhancements in memory underlie the reinstatement of prior drug-related contexts and propel drug use. While a large rodent literature has focused on reward’s influence on hippocampal-dependent plasticity, relatively little work has characterized these processes in human adults or adolescents. We propose to study the influence of reward on memory consolidation and episodic memory throughout adolescence into early adulthood. We will study 90 14- to 25- year-old healthy subjects using multiple neuroimaging modalities. All participants will complete a reward memory paradigm, which will allow for the quantification of the influence of reward on episodic memory, i.e. a behavioral marker of hippocampal consolidation. Memory enhancements for reward will be associated with neural markers related to memory consolidation. In Aim 1, we will characterize associations between reward-mediated memory enhancements and neural markers of consolidation in healthy adults, allowing us to translate and extend animal models into a human neuroscience framework. In Aim 2, we will characterize these relationships throughout adolescence to better understand how adolescents heighted sensitivity to reward influences long-term memory representations throughout development. This work will provide a deeper understanding of how hippocampal plasticity is influenced by reward throughout adolescence, and bolster a foundation to better understand the vulnerability to substance abuse in this population.

项目总结/摘要 青春期标志着多巴胺系统参与增加的状态，这是一种神经生物学状态， 奖励动机行为的增加。虽然在这段时间内增加多巴胺信号 主要支持适应性发展过程，如探索和奖励学习，它可以 也推动与物质使用和滥用相关的冒险行为。著名的动物模型 表明多巴胺系统的参与和奖励敏感性的增加可以增加可塑性， 海马学习系统的巩固，导致对奖励事件的记忆增强。关键是， 这些记忆的增强是恢复先前与毒品有关的背景和推动吸毒的基础。 虽然大量啮齿类动物的文献都集中在奖赏对大脑可塑性的影响上， 相对较少的工作描述了成年人或青少年的这些过程。我们建议研究 奖励对整个青春期到早期记忆巩固和情景记忆的影响 成年我们将使用多种神经成像方式研究90名14至25岁的健康受试者。所有 参与者将完成奖励记忆范式，这将允许量化的影响， 奖励对情节记忆的影响，即海马巩固的行为标记。内存增强功能， 奖励将与记忆巩固相关的神经标记物相关联。在目标1中，我们将描述 奖励介导的记忆增强与健康人巩固记忆的神经标志物之间的关系 这使得我们能够将动物模型转化和扩展到人类神经科学框架中。在目标2中， 我将描述这些关系在整个青春期，以更好地了解青少年如何提高 对奖赏的敏感性影响着整个发育过程中的长期记忆表征。这项工作将 提供了一个更深入的理解海马可塑性是如何影响整个奖励 青少年，并加强基础，以更好地了解在这方面的药物滥用的脆弱性 人口