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Influence of reward on memory consolidation in adults and adolescence

奖励对成人和青少年记忆巩固的影响

基本信息

批准号：
9450704
负责人：
Vishnu Pradeep Murty
金额：
$ 23.01万
依托单位：
TEMPLE UNIV OF THE COMMONWEALTH
依托单位国家：
美国
项目类别：
财政年份：
2019
资助国家：
美国
起止时间：
2019-06-01 至 2021-05-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/9450704
关键词：
Adolescence Adolescent Adult Age Alcohol or Other Drugs use Animal Model Animals Behavior Behavioral Categories Data Development Developmental Process Dopamine Drug abuse Drug usage Electroencephalography Episodic memory Esthesia Event Foundations Functional Magnetic Resonance Imaging Height Hippocampus (Brain)Hour Human Impulsivity Individual Intervention Investigation Lead Learning Literature Long-Term Potentiation Measures Mediating Memory Modality Modeling Motivation Napping Neurobiology Neurosciences Participant Pharmaceutical Preparations Population Process Research Rewards Risk Risk-Taking Rodent Rodent Model Short-Term Memory Signal Transduction Sleep Slow-Wave Sleep Substance Use Disorder Substance abuse problem Support System System Techniques Testing Time Translating Work behavioral pharmacology density dopamine system drug craving drug relapse early adolescence emerging adult long term memory memory consolidation memory encoding mesolimbic system motivated behavior multimodality neurobehavioral neurodevelopment neuroimaging neuroregulation novel relating to nervous system sensory cortex sleep spindle tool

项目摘要

Project Summary/Abstract Adolescence marks a state of increased engagement of dopamine systems, a neurobiological state associated with increased reward-motivated behaviors. While increased dopamine signaling during this time period predominately supports adaptive developmental processes, such as exploration and reward learning, it can also propel risk taking behaviors associated with substance use and abuse. Prominent animal models have shown that engagement of dopamine systems and increased reward sensitivtycan increase plasticity and consolidation in hippocampal learning systems, resulting in enhanced memory for rewarding events. Critically, these enhancements in memory underlie the reinstatement of prior drug-related contexts and propel drug use. While a large rodent literature has focused on reward’s influence on hippocampal-dependent plasticity, relatively little work has characterized these processes in human adults or adolescents. We propose to study the influence of reward on memory consolidation and episodic memory throughout adolescence into early adulthood. We will study 90 14- to 25- year-old healthy subjects using multiple neuroimaging modalities. All participants will complete a reward memory paradigm, which will allow for the quantification of the influence of reward on episodic memory, i.e. a behavioral marker of hippocampal consolidation. Memory enhancements for reward will be associated with neural markers related to memory consolidation. In Aim 1, we will characterize associations between reward-mediated memory enhancements and neural markers of consolidation in healthy adults, allowing us to translate and extend animal models into a human neuroscience framework. In Aim 2, we will characterize these relationships throughout adolescence to better understand how adolescents heighted sensitivity to reward influences long-term memory representations throughout development. This work will provide a deeper understanding of how hippocampal plasticity is influenced by reward throughout adolescence, and bolster a foundation to better understand the vulnerability to substance abuse in this population.

项目总结/文摘