Influence of reward on memory consolidation in adults and adolescence

奖励对成人和青少年记忆巩固的影响

• 批准号: 9450704
• 负责人: Vishnu Pradeep Murty
• 金额: $ 23.01万
• 依托单位: TEMPLE UNIV OF THE COMMONWEALTH
• 依托单位国家: 美国
• 财政年份: 2019
• 资助国家: 美国
• 起止时间: 2019-06-01 至 2021-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9450704
• 关键词: Adolescence; Adolescent; Adult; Age; Alcohol or Other Drugs use; Animal Model; Animals; Behavior; Behavioral; Categories; Data; Development; Developmental Process; Dopamine; Drug abuse; Drug usage; Electroencephalography; Episodic memory; Esthesia; Event; Foundations; Functional Magnetic Resonance Imaging; Height; Hippocampus (Brain); Hour; Human; Impulsivity; Individual; Intervention; Investigation; Lead; Learning; Literature; Long-Term Potentiation; Measures; Mediating; Memory; Modality; Modeling; Motivation; Napping; Neurobiology; Neurosciences; Participant; Pharmaceutical Preparations; Population; Process; Research; Rewards; Risk; Risk-Taking; Rodent; Rodent Model; Short-Term Memory; Signal Transduction; Sleep; Slow-Wave Sleep; Substance Use Disorder; Substance abuse problem; Support System; System; Techniques; Testing; Time; Translating; Work; behavioral pharmacology; density; dopamine system; drug craving; drug relapse; early adolescence; emerging adult; long term memory; memory consolidation; memory encoding; mesolimbic system; motivated behavior; multimodality; neurobehavioral; neurodevelopment; neuroimaging; neuroregulation; novel; relating to nervous system; sensory cortex; sleep spindle; tool

Project Summary/Abstract Adolescence marks a state of increased engagement of dopamine systems, a neurobiological state associated with increased reward-motivated behaviors. While increased dopamine signaling during this time period predominately supports adaptive developmental processes, such as exploration and reward learning, it can also propel risk taking behaviors associated with substance use and abuse. Prominent animal models have shown that engagement of dopamine systems and increased reward sensitivtycan increase plasticity and consolidation in hippocampal learning systems, resulting in enhanced memory for rewarding events. Critically, these enhancements in memory underlie the reinstatement of prior drug-related contexts and propel drug use. While a large rodent literature has focused on reward’s influence on hippocampal-dependent plasticity, relatively little work has characterized these processes in human adults or adolescents. We propose to study the influence of reward on memory consolidation and episodic memory throughout adolescence into early adulthood. We will study 90 14- to 25- year-old healthy subjects using multiple neuroimaging modalities. All participants will complete a reward memory paradigm, which will allow for the quantification of the influence of reward on episodic memory, i.e. a behavioral marker of hippocampal consolidation. Memory enhancements for reward will be associated with neural markers related to memory consolidation. In Aim 1, we will characterize associations between reward-mediated memory enhancements and neural markers of consolidation in healthy adults, allowing us to translate and extend animal models into a human neuroscience framework. In Aim 2, we will characterize these relationships throughout adolescence to better understand how adolescents heighted sensitivity to reward influences long-term memory representations throughout development. This work will provide a deeper understanding of how hippocampal plasticity is influenced by reward throughout adolescence, and bolster a foundation to better understand the vulnerability to substance abuse in this population.

项目概要/摘要 青春期标志着多巴胺系统参与增加的状态，这是一种与 奖励动机行为的增加。虽然在此期间多巴胺信号增加 主要支持适应性发展过程，例如探索和奖励学习，它可以 还推动与药物使用和滥用相关的冒险行为。著名的动物模型有 研究表明，多巴胺系统的参与和奖励敏感性的增加可以增加可塑性和 巩固海马学习系统，从而增强对奖励事件的记忆。关键的是， 这些记忆力的增强是恢复先前与毒品有关的环境的基础，并推动了毒品的使用。 虽然大量啮齿动物文献关注奖励对海马依赖性可塑性的影响， 相对较少的研究工作描述了成年人或青少年的这些过程。我们建议学习 奖励对整个青春期到早期的记忆巩固和情景记忆的影响 成年期。我们将使用多种神经影像学方法研究 90 名 14 至 25 岁的健康受试者。全部 参与者将完成奖励记忆范例，这将允许量化 对情景记忆的奖励，即海马巩固的行为标志。记忆增强 奖励将与记忆巩固相关的神经标记相关。在目标 1 中，我们将描述 奖励介导的记忆增强与健康人巩固神经标志物之间的关联 成人，使我们能够将动物模型转化并扩展到人类神经科学框架。在目标 2 中，我们 将描述整个青春期的这些关系，以更好地了解青少年如何身高 对奖励的敏感性影响整个发展过程中的长期记忆表征。这项工作将 更深入地了解海马可塑性如何受到奖励的影响 青春期，并为更好地了解青少年中药物滥用的脆弱性奠定基础 人口。