Influence of reward on memory consolidation in adults and adolescence

奖励对成人和青少年记忆巩固的影响

• 批准号: 9450704
• 负责人: Vishnu Pradeep Murty
• 金额: $ 23.01万
• 依托单位: TEMPLE UNIV OF THE COMMONWEALTH
• 依托单位国家: 美国
• 财政年份: 2019
• 资助国家: 美国
• 起止时间: 2019-06-01 至 2021-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9450704
• 关键词: Adolescence; Adolescent; Adult; Age; Alcohol or Other Drugs use; Animal Model; Animals; Behavior; Behavioral; Categories; Data; Development; Developmental Process; Dopamine; Drug abuse; Drug usage; Electroencephalography; Episodic memory; Esthesia; Event; Foundations; Functional Magnetic Resonance Imaging; Height; Hippocampus (Brain); Hour; Human; Impulsivity; Individual; Intervention; Investigation; Lead; Learning; Literature; Long-Term Potentiation; Measures; Mediating; Memory; Modality; Modeling; Motivation; Napping; Neurobiology; Neurosciences; Participant; Pharmaceutical Preparations; Population; Process; Research; Rewards; Risk; Risk-Taking; Rodent; Rodent Model; Short-Term Memory; Signal Transduction; Sleep; Slow-Wave Sleep; Substance Use Disorder; Substance abuse problem; Support System; System; Techniques; Testing; Time; Translating; Work; behavioral pharmacology; density; dopamine system; drug craving; drug relapse; early adolescence; emerging adult; long term memory; memory consolidation; memory encoding; mesolimbic system; motivated behavior; multimodality; neurobehavioral; neurodevelopment; neuroimaging; neuroregulation; novel; relating to nervous system; sensory cortex; sleep spindle; tool

Project Summary/Abstract Adolescence marks a state of increased engagement of dopamine systems, a neurobiological state associated with increased reward-motivated behaviors. While increased dopamine signaling during this time period predominately supports adaptive developmental processes, such as exploration and reward learning, it can also propel risk taking behaviors associated with substance use and abuse. Prominent animal models have shown that engagement of dopamine systems and increased reward sensitivtycan increase plasticity and consolidation in hippocampal learning systems, resulting in enhanced memory for rewarding events. Critically, these enhancements in memory underlie the reinstatement of prior drug-related contexts and propel drug use. While a large rodent literature has focused on reward’s influence on hippocampal-dependent plasticity, relatively little work has characterized these processes in human adults or adolescents. We propose to study the influence of reward on memory consolidation and episodic memory throughout adolescence into early adulthood. We will study 90 14- to 25- year-old healthy subjects using multiple neuroimaging modalities. All participants will complete a reward memory paradigm, which will allow for the quantification of the influence of reward on episodic memory, i.e. a behavioral marker of hippocampal consolidation. Memory enhancements for reward will be associated with neural markers related to memory consolidation. In Aim 1, we will characterize associations between reward-mediated memory enhancements and neural markers of consolidation in healthy adults, allowing us to translate and extend animal models into a human neuroscience framework. In Aim 2, we will characterize these relationships throughout adolescence to better understand how adolescents heighted sensitivity to reward influences long-term memory representations throughout development. This work will provide a deeper understanding of how hippocampal plasticity is influenced by reward throughout adolescence, and bolster a foundation to better understand the vulnerability to substance abuse in this population.

项目摘要/摘要 青少年标志着多巴胺系统参与度增加的状态，多巴胺系统是一种与神经生物学状态相关的状态 随着奖励动机的行为的增加。在此期间增加了多巴胺信号传导 主要支持适应性发展过程，例如探索和奖励学习，它可以 还推动冒险的风险与药物使用和滥用相关的行为。著名动物模型有 表明多巴胺系统的参与和提高奖励灵敏度和 海马学习系统中的合并，从而增强了记忆力的奖励事件。批判性， 记忆中的这些增强是恢复先前药物相关的上下文和推动药物使用的基础。 尽管大型啮齿动物文献集中于奖励对海马依赖性可塑性的影响，但 在人类或青少年中，这些过程的特征相对较少。我们建议学习 奖励对整个青少年的记忆合并和情节记忆的影响 成年。我们将使用多种神经影像学手段研究90至25岁的健康受试者。全部 参与者将完成奖励记忆范式，这将允许量化 奖励情节记忆，即海马巩固的行为标记。内存增强 奖励将与与记忆巩固有关的神经标记有关。在AIM 1中，我们将描述 奖励介导的记忆增强与健康合并的神经标记之间的关联 成年人，使我们能够将动物模型转化为人类神经科学框架。在AIM 2中，我们 将在整个青少年中表征这些关系，以更好地了解青少年如何高高 对奖励敏感性影响整个发展的长期记忆表示。这项工作将 对整个奖励影响海马可塑性的影响有更深入的了解 青少年，并为更好地了解底物滥用的脆弱性增强基础 人口。