Ion Mobility Spectrometry Methods Used for On-line Measurements of Biopharmaceuti
用于生物制药在线测量的离子淌度光谱分析方法
基本信息
- 批准号:8524734
- 负责人:
- 金额:$ 17.06万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2013
- 资助国家:美国
- 起止时间:2013-04-10 至 2014-09-30
- 项目状态:已结题
- 来源:
- 关键词:AddressAffectAffinityAmino AcidsBedsBiologicalBiological Response Modifier TherapyBiomanufacturingBiotechnologyCell Culture TechniquesChargeChemicalsCost SavingsCulture MediaDetectionDevelopmentElectrospray IonizationEnsureEscherichia coliFeedbackFermentationFingerprintFrequenciesGasesGoalsHigh Pressure Liquid ChromatographyIndividualIndustryLaboratoriesLiquid ChromatographyLocationMaintenanceManufacturer NameMeasurementMeasuresMethodsMonitorMono-SMonosaccharidesNonesterified Fatty AcidsNutrientOutputPerformancePharmacologic SubstancePhaseProcessProductionPropertyResearch Project GrantsSamplingSiteSmall Business Innovation Research GrantSourceSpectrometrySpeedSystemTechniquesTestingTimeTranslatingTriglyceridesWaste Productsanalytical methodbasebioprocesscostcost effectivedesignfeedingimprovedinnovationinsightinstrumention mobilitymanufacturing facilitymanufacturing processmass spectrometermethod developmentorganic acidprototypepublic health relevancerapid techniqueresearch and developmentresearch studysmall moleculetooltrend
项目摘要
DESCRIPTION: The ultimate goal of the Phase I SBIR project is to establish the feasibility of using ion mobility spectrometry (IMS) or liquid chromatography-IMS (LC-IMS) as a fast, selective and sensitive method for rapid monitoring of bio manufacturing processes for on-line use to improve the understanding of the process and provide real-time feedback. Excellims will develop the LC-IMS method for monitoring the most important chemical species that inform the process monitors. Bio manufacturers are limited by current real-time monitoring tools and must determine quality after the product is completed. Therefore, successful development of the method will fulfill the need for tools that increase the efficiency of the entire process that will
translate into operational and cost savings for mass producing biologics.
描述:第一阶段 SBIR 项目的最终目标是确定使用离子迁移谱 (IMS) 或液相色谱-IMS (LC-IMS) 作为一种快速、选择性和灵敏的方法来快速监测在线使用的生物制造过程的可行性,以提高对过程的理解并提供实时反馈。 Excellims 将开发 LC-IMS 方法来监测最重要的化学物质,为过程监测人员提供信息。生物制造商受到当前实时监控工具的限制,必须在产品完成后确定质量。因此,该方法的成功开发将满足对提高整个过程效率的工具的需求。
转化为大规模生产生物制品的运营和成本节省。
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
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Ching Wu其他文献
Ching Wu的其他文献
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{{ truncateString('Ching Wu', 18)}}的其他基金
ESI-IMS for Rapid On-site Cleaning Validation in Pharmaceutical Manufacturing
用于制药制造中快速现场清洁验证的 ESI-IMS
- 批准号:
7536634 - 财政年份:2008
- 资助金额:
$ 17.06万 - 项目类别:
Chiral Ion Mobility Spectrometry for Rapid Separation of Enantiomeric Compounds
用于快速分离对映体化合物的手性离子淌度光谱法
- 批准号:
7910033 - 财政年份:2007
- 资助金额:
$ 17.06万 - 项目类别:
Chiral Ion Mobility Spectrometry for Rapid Separation of Enantiomeric Compounds
用于快速分离对映体化合物的手性离子淌度光谱法
- 批准号:
7220519 - 财政年份:2007
- 资助金额:
$ 17.06万 - 项目类别:
Chiral Ion Mobility Spectrometry for Rapid Separation of Enantiomeric Compounds
用于快速分离对映体化合物的手性离子淌度光谱法
- 批准号:
8101833 - 财政年份:2007
- 资助金额:
$ 17.06万 - 项目类别:
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