Penn TREC Survivor Center

宾夕法尼亚 TREC 幸存者中心

• 批准号: 8504802
• 负责人: Kathryn H. Schmitz
• 金额: $ 175.67万
• 依托单位: UNIVERSITY OF PENNSYLVANIA
• 依托单位国家: 美国
• 财政年份: 2011
• 资助国家: 美国
• 起止时间: 2011-06-24 至 2016-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8504802
• 关键词: Address; Adverse effects; Adverse event; Affect; Animal Model; Animals; Applications Grants; Area; Basic Science; Behavior Therapy; Bioinformatics; Biological Markers; Biology; Body Image; Body Weight decreased; Breast Cancer Treatment; Caloric Restriction; Cancer Biology; Cancer Survivor; Cancer Survivorship; Caring; Clinical; Clinical Oncology; Clinical Trials; Collaborations; Common Data Element; Communication; Communities; Continuance of life; Cost Effectiveness Analysis; Cost Savings; Costs and Cost Analysis; County; Data; Decision Making; Development; Education; Education and Outreach; Educational Curriculum; Elements; Event; Exercise; Flare; Fostering; Funding; Glues; Goals; Grant; Health Personnel; Health behavior; Human; Image; Imaging Techniques; Individual; Infection; Institutes; Institution; Interdisciplinary Study; Intervention; Knowledge; Late Effects; Lead; Length; Lymphangiogenesis; Lymphedema; Malignant Neoplasms; Manuscripts; Measures; Medical; Medicare; Minnesota; Mission; Modeling; Monitor; Mus; Nature; Neoplasm Metastasis; Nursing Faculty; Obesity; Outcome; Overweight; Pathway interactions; Patients; Physicians; Pilot Projects; Policies; Population; Postdoctoral Fellow; Postmenopause; Quality of life; Quality-Adjusted Life Years; Randomized; Recruitment Activity; Recurrence; Research; Research Personnel; Research Project Grants; Research Proposals; Research Support; Risk; Scientist; Series; Services; Societies; Surveys; Survivors; System; T-Cell Receptor-Rearrangement Excision DNA Circles; Testing; Training; Training Activity; Translating; Translations; Validation; Woman; Work; cancer recurrence; cancer therapy; career; clinical application; clinical care; clinical practice; cohort; community setting; cost; cost effective; cost effectiveness; cost utility analysis; data management; data sharing; design; distributed data; energy balance; evidence base; health economics; improved; in vivo; innovation; interdisciplinary collaboration; interest; intervention effect; malignant breast neoplasm; mouse model; novel; outreach program; pre-doctoral; primary outcome; programs; success; survivorship; symposium; weight loss intervention

The overall goal of the Penn TREC Survivor Center is to improve the length and quality of cancer survivorship through establishing a sustainable transdisciplinary research, education, and outreach program that extends from 'bench to trench'. The proposed center will enhance knowledge of the causal associations of energy balance and breast cancer recurrence, from animal to human models, as well as exploring and integrating this knowledge with broad population impact at the policy level for control of obesity related adverse events among cancer survivors. Three projects are proposed. Project 1 will explore whether exercise and/or weight loss will alter breast cancer recurrence in mice and explore effects on biomarkers of mechanistic pathways hypothesized to explain these effects. Project 2 will translate project 1 biomarker findings into a human model. Intervention effects on clinical lymphedema outcomes will also be assessed in Project 2. Project 3 will assess whether exercise and/or weight loss is cost effective for breast cancer survivors with lymphedema. Organizationally, the administrative core will serve as the glue between the investigators, so that as the projects, training activities, and developmental pilots unfold, the transdisciplinary, translational nature of the center is preserved and extended. The developmental core will accelerate capacity to study effects of energetics on cancer recurrence by combining the unique strengths of our institution in obesity and cancer biology and extending the TREC initiative solidly into cancer survivorship. The education/training and outreach core will train scientists and clinicians regarding energy balance and cancer survivorship, serving the dual purpose of educating health care providers regarding the unique energy balance issues in survivors and spurring interest in research on this growing population across the spectrum from basic science to clinical applications. The Penn TREC Survivor Center will leverage the considerable strengths of Penn scientific investigators and physician scientists to accelerate capacity for research on energetics, cancer recurrence and persistent adverse treatment effects as well as disseminating those findings to improve clinical care and outcomes for cancer survivors.

宾州TREC幸存者中心的总体目标是通过建立一个可持续的跨学科研究，教育和外展计划，从“板凳到战壕”，提高癌症生存的长度和质量。拟议的中心将提高能量平衡和乳腺癌复发的因果关系的知识，从动物到人类模型，以及探索和整合这一知识与广泛的人口影响，在政策层面控制肥胖相关的不良事件癌症幸存者。提出了三个项目。项目1将探索运动和/或减肥是否会改变小鼠乳腺癌复发，并探索对机制途径生物标志物的影响，以解释这些影响。项目2将项目1的生物标志物发现转化为人类模型。还将在项目2中评估干预对临床水肿结局的影响。项目3将评估运动和/或减肥是否对患有水肿的乳腺癌幸存者具有成本效益。从理论上讲，行政核心将作为研究人员之间的粘合剂，以便随着项目，培训活动和发展试点的展开，该中心的跨学科，翻译性质得到保留和扩展。发展核心将通过结合我们机构在肥胖和癌症生物学方面的独特优势，并将TREC计划稳固地扩展到癌症生存中，来加速研究能量学对癌症复发影响的能力。教育/培训和外展核心将培训科学家和临床医生关于能量平衡和癌症生存，服务于双重目的，即教育医疗保健提供者关于幸存者独特的能量平衡问题，并激发对从基础科学到临床应用的不断增长的人口的研究兴趣。宾州TREC幸存者中心将利用宾州科学调查人员和医生科学家的相当大的优势，加快对能量学、癌症复发和持续不良治疗效果的研究能力，并传播这些研究结果，以改善癌症幸存者的临床护理和结果。